Donglu Zhang - Publications, H-index & Citations

Donglu Zhang

Genentech Inc.

47H指数

231论文数

8.1K被引数

收录论文 57

发表时间

Antibody-Mediated Delivery of BRM/BRG1 Protein Degraders Affords Strong Antitumor Efficacy in Multiple BRM-Dependent Non-Small Cell Lung Cancer Xenograft Models 抗体介导的BRM/BRG1蛋白降解剂递送在多种BRM依赖性非小细胞肺癌异种移植模型中显示出强大的抗肿瘤疗效

Journal of Medicinal Chemistry

IF6.8

2026-05-17

PREAI

Summer A. Baker Dockrey; Pravin Chandra; Huifen Chen; Shu Chen; Tommy K. Cheung; Ely Cosino; Yusi Cui; Stephanie Dale; Martine Darwish; Nicholas Dompe; Geoffrey Del Rosario; Mary Ann Go; Nikkia Hamidi; Mingtao He; Isidro Hötzel; Thomas Januario; Hartmut Koeppen; Julien Lafrance-Vanasse; Douglas Leipold; Chunsing Li; Joyce Liu; Ying Lu; Shabkhaiz Masih; Stephanie Monson; Rachana Ohri; Woody Perng; Thomas H. Pillow; Christopher M. Rose; Rebecca K. Rowntree; Jack Sadowsky; William Sawyer; Richard Vandlen; John Wai; Jian Wang; XinXin Wang; Yanmei Xin; Xiaofen Ye; Shang-Fan Yu; Donglu Zhang; Fang Zhang; Nancy Zhang; Robert L. Yauch; Peter S. Dragovich

SMARCA2 PROTAC-dendrimer conjugates for the treatment of non-small cell lung cancer SMARCA2 PROTAC-树状大分子缀合物用于非小细胞肺癌的治疗

Journal of Pharmaceutical Sciences

IF3.8

2026-04-15

PREAI

Matthew O’Brien Laramy; Rosliana Halim; Summer Baker Dockrey; Shang-Fan Yu; Geoff del Rosario; Robert L. Yauch; Xiaofen Ye; Donglu Zhang; Ely Cosino; Graham Heery; Gareth Chadwick; David Owen; Richard Hufton

Ketone Reduction Drives Major Circulating Metabolites of GDC-8264 in Humans GDC-8264在人体内的主要循环代谢物由酮还原驱动

Drug Metabolism and Disposition

IF4

2026-03-25

PREAI

Shuai Wang; Susan Wong; Antonio DiPasquale; Shuguang Ma; Allen Y. Hong; Teresa Mulder; Simon Wong; Arturo L. Aguirre; Caitlin Chua; Liuxi Chen; Jialin Mao; Smita Kshirsagar; Cyrus S. Khojasteh; Donglu Zhang

Beyond Single-Dose Human Mass Balance Study: Minimizing Subject Confinement and Enabling True Steady State Assessment with a Novel Multiple-Dose Design Proposal 超越单剂量人体总平衡研究：通过一种新型多剂量设计方案，减少受试者隔离并实现真正的稳态评估

Drug Metabolism and Disposition

IF4

2025-09-26

PREAI

Shuai Wang; Weiping Zhao; Sandhya Mandlekar; Lin Pan; Donglu Zhang; Cyrus Khojasteh; Cornelis E.C.A. Hop

Metabolism of new drug modalities research advances – 2024 year in review 新药治疗模式代谢研究进展——2024年度回顾

Drug Metabolism Reviews

IF3.8

2025-08-12

PREAI

Bin Ma; Upendra A. Argikar; Luying Chen; Lionel Cheruzel; Sungjoon Cho; Ting-Jia Gu; Simon Hauri; Valerie M. Kramlinger; Xiuli Li; Joyce Liu; Simone Schadt; Herana Kamal Seneviratne; Rachel Liuqing Shi; Lloyd Wei Tat Tang; Donglu Zhang; Guo Zhong; S. Cyrus Khojasteh

Characterization of Hydrolase Activity in Ocular Tissues of Humans and Preclinical Species 人及非临床物种眼部组织中水解酶活性的表征

Drug Metabolism and Disposition

IF4

2025-08-11

PREAI

Mengyue Li; Donglu Zhang; Robert S. Jones; Lionel Cheruzel; S. Cyrus Khojasteh; Hsu-Hsin Chen; Emel Adaligil; Treefa Shwani; Leah A. Owen; Ivana K. Kim; Margaret M. DeAngelis; Bin Ma

Elucidating Molecular Mechanisms of Drug-Induced Hepatotoxicity of Lapatinib 阐明拉帕替尼药物诱导肝毒性的分子机制

Journal of Medicinal Chemistry

IF6.8

2025-07-25

PREAI

Qinying Yu; Li Ma; Leah M. Norona; Peter S. Dragovich; Jianshuang Wang; Shuai Wang; Yi-Chen Chen; S. Cyrus Khojasteh; Jane R. Kenny; Brian J. Dean; Cornelis E. C. A. Hop; Sarah J. Robinson; Ke Sherry Li; Lionel Cheruzel; Aaron Fullerton; Yunxing Cheng; Mingtao He; Xinpeng Wang; Klarissa D. Jackson; Zhengyin Yan; Donglu Zhang

Mechanistic Characterization of the Potency of THIOMAB Antibody-Drug Conjugates Targeting Staphylococcus aureus and ETbR-Expressing Tumor Cells Using Quantitative LC-MS/MS Analysis of Intracellular Drug Accumulation

BIOCONJUGATE CHEMISTRY

IF3.9

2025-04-01

PREAI

Hernandez-Barry, Hilda; dela Cruz-Chuh, Josefa; Kajihara, Kimberly K.; Asundi, Jyoti; Vandlen, Richard; Zhang, Donglu; Hazenbos, Wouter L. W.; Pillow, Thomas; Liu, Yichin; Wu, Cong; Kozak, Katherine R.; Loyet, Kelly M.

Optical 14C Tracing for Biological and Pharmaceutical Applications Using Two-Color Cavity Ringdown Spectroscopy 基于双色腔衰荡光谱的光学14C示踪在生物和制药领域的应用

ANALYTICAL CHEMISTRY

IF6.7

2025-03-03

PREAI

Jiang, Jun; Baliu-Rodriguez, David; Mccartt, A. Daniel; Ognibene, Ted; Malfatti, Michael A.; Zhang, Donglu; Ma, Shuguang; Khojasteh, S. Cyrus

Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism

DRUG METABOLISM REVIEWS

IF3.8

2025-02-05

PREAI

Liu, Joyce; Zhang, Donglu

On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-07-01

PREAI

Adhikari, Pragya; Li, Guangmin; Go, Maryann; Mandikian, Danielle; Rafidi, Hanine; Ng, Carl; Anifa, Sagana; Johnson, Kevin; Bao, Linda; Barry, Hilda Hernandez; Rowntree, Rebecca; Agard, Nicholas; Wu, Cong; Chou, Kang-Jye; Zhang, Donglu; Kozak, Katherine R.; Pillow, Thomas H.; Lewis, Gail D.; Yu, Shang-Fan; Boswell, C. Andrew; Sadowsky, Jack D.

Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-05-29

PREAI

Wu, Hao; Murray, Jeremy; Ishisoko, Noriko; Frommlet, Alexandra; Deshmukh, Gauri; Dipasquale, Antonio; Mulvihill, Melinda M.; Zhang, Donglu; Quinn, John G.; Blake, Robert A.; Fairbrother, Wayne J.; Fuhrmann, Jakob

Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs

COMMUNICATIONS MEDICINE

IF6.3

2024-05-16

OAAI

Zhang, Donglu; Ma, Bin; Dragovich, Peter S.; Ma, Li; Chen, Shu; Chen, Eugene C.; Ye, Xiaofen; Liu, Joyce; Pizzano, Jennifer; Bortolon, Elizabeth; Chan, Emily; Zhang, Xing; Chen, Yi-Chen; Levy, Elizabeth S.; Yauch, Robert L.; Khojasteh, S. Cyrus; Hop, Cornelis E. C. A.

Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings

ADVANCED DRUG DELIVERY REVIEWS

IF17.6

2024-04-01

OAAI

Liao, Michael Z.; Lu, Dan; Lu, Tong; Gibiansky, Leonid; Deng, Rong; Samineni, Divya; Dere, Randall; Lin, Andy; Hirata, Jamie; Shen, Ben-Quan; Zhang, Donglu; Li, Dongwei; Li, Chunze; Miles, Dale

The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results

NATURE COMMUNICATIONS

IF15.7

2024-01-11

OAAI

Lewis, Gail D.; Li, Guangmin; Guo, Jun; Yu, Shang-Fan; Fields, Carter T.; Lee, Genee; Zhang, Donglu; Dragovich, Peter S.; Pillow, Thomas; Wei, Binqing; Sadowsky, Jack; Leipold, Douglas; Wilson, Tim; Kamath, Amrita; Mamounas, Michael; Lee, M. Violet; Saad, Ola; Choeurng, Voleak; Ungewickell, Alexander; Monemi, Sharareh; Crocker, Lisa; Kalinsky, Kevin; Modi, Shanu; Jung, Kyung Hae; Hamilton, Erika; LoRusso, Patricia; Krop, Ian; Schutten, Melissa M.; Commerford, Renee; Sliwkowski, Mark X.; Cho, Eunpi

The Importance of Tracking Missing Metabolites: How and Why?

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-09-28

PREAI

Wang, Shuai; Ballard, T. Eric; Christopher, Lisa J.; Foti, Robert S.; Gu, Chungang; Khojasteh, S. Cyrus; Liu, Joyce; Ma, Shuguang; Ma, Bin; Obach, R. Scott; Schadt, Simone; Zhang, Zhoupeng; Zhang, Donglu

Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2023-09-01

OAAI

Maher, Jonathan; Stagg, Nicola; Cain, Gary; Andaya, Roxanne; Katavolos, Paula; Gallardo-Chang, Fermin; Pham, Anna; Ye, Xiaofen; Januario, Tom; Alcantar, Tuija; Caothien, Roger; Roose-Girma, Merone; Zhang, Donglu; Li, Ruina; Chen, Shu; Yauch, Robert L.

GTP1 metabolic stability assessment: A study of the tau PET tracer [18F] GTP1

NUCLEAR MEDICINE AND BIOLOGY

IF3

2023-09-01

PREAI

Marik, Jan; Rich, Sharyl; Deshmukh, Gauri; Zhang, Donglu; Tinianow, Jeff; Cai, Jingwei; Wong, Susan; Bobba, Sudheer; Dement, Kevin; Liu, Ning; Halladay, Jason; Sanabria-Bohorquez, Sandra; Cheruzel, Lionel; Khojasteh, Cyrus

Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs

PHARMACEUTICS

IF5.5

2023-08-08

OAAI

Kou, Ponien; Levy, Elizabeth S.; Nguyen, An D.; Zhang, Donglu; Chen, Shu; Cui, Yusi; Zhang, Xing; Broccatelli, Fabio; Pizzano, Jennifer; Cantley, Jennifer; Bortolon, Elizabeth; Rousseau, Emma; Berlin, Michael; Dragovich, Peter; Sethuraman, Vijay

Formulation and Scale-Up of Fast-Dissolving Lumefantrine Nanoparticles for Oral Malaria Therapy

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2023-08-01

PREAI

Armstrong, Madeleine; Wang, Leon; Ristroph, Kurt; Tian, Chang; Yang, Jiankai; Ma, Lirong; Panmai, Santipharp; Zhang, Donglu; Nagapudi, Karthik; Prud'homme, Robert K.

研究方向