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W

William Vainchenker

INSERM
H指数:109
被引数:4.4万

个人简介

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荣誉奖项

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MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

MCM8和MCM9缺乏导致终生的造血DNA损伤增加，进而驱动p53依赖性髓系肿瘤的发生。

Cell Reports
IF6.9
2025-12-180
OAAI
Malik Lutzmann; Florence Bernex; Cindy da Costa de Jesus; Dana Hodroj; Caroline Marty; Isabelle Plo; William Vainchenker; Marie Tosolini; Luc Forichon; Caroline Bret; Sophie Queille; Candice Marchive; Jean-Sébastien Hoffmann; Marcel Méchali
Casein Kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization

Casein Kinase 1α 通过驱动巨核细胞成熟和细胞骨架组织来基本调控血小板生成。

Blood
IF23.1
2025-08-050
OA
Ferdinand Kollotzek; Kristina Mott; Melina Fischer; Betül Findik; Vanessa Göb; Mailin-Christin Manke; Carla Emilia Borst; Amin Polzin; Martin D. Burkhalter; Anita Eckly; Tamam Bakchoul; Melanie Philipp; Samuel J. Holzmayer; Leticia Quintanilla-Fend; Claudia Lengerke; Meinrad Gawaz; Catherine Leon; David Stegner; Bernhard Nieswandt; William Vainchenker; Markus Bender; Julia Skokowa; Harald Schulze; Patrick Münzer; Oliver Borst
JAK2 inhibition mediates clonal selection of RAS pathway mutations in myeloproliferative neoplasms

JAK2 抑制介导了骨髓增殖性肿瘤中 RAS 通路突变的克隆选择。

Nature Communications
IF15.7
2025-07-080
OAAI
Nabih Maslah; Nina Kaci; Blandine Roux; Gabriela Alexe; Raphael Marie; Hélène Pasquer; Emmanuelle Verger; Rafael Daltro De Oliveira; Cécile Culeux; Bochra Mlayah; Nicolas Gauthier; Fanny Gonzales; Lin-Pierre Zhao; Saravanan Ganesan; Panhong Gou; Frank Ling; Juliette Soret-Dulphy; Nathalie Parquet; William Vainchenker; Emmanuel Raffoux; Rose Ann Padua; Stéphane Giraudier; Caroline Marty; Isabelle Plo; Camille Lobry; Kimberly Stegmaier; Alexandre Puissant; Jean-Jacques Kiladjian; Bruno Cassinat; Lina Benajiba
Monocytes generated by interleukin-6-treated human hematopoietic stem and progenitor cells secrete calprotectin that inhibits erythropoiesis

由白介素-6处理的造血干细胞和祖细胞生成的单核细胞分泌钙卫蛋白，该物质抑制红细胞生成。

ISCIENCE
IF4.1
2025-01-010
PRE
Marchand, Valentine; Laplane, Lucie; Valensi, Louis; Plo, Isabelle; Aglave, Marine; Silvin, Aymeric; Pasquier, Florence; Porteu, Francoise; Vainchenker, William; Selimoglu-Buet, Dorothee; Droin, Nathalie; Raslova, Hana; Marcel, Virginie; Diaz, Jean-Jacques; Fontenay, Michaela; Solary, Eric
Comparative clinical and molecular landscape of primary and secondary myelofibrosis: Superior performance of MIPSS70+v2.0 over MYSEC-PM
AMERICAN JOURNAL OF HEMATOLOGY
IF9.9
2024-01-264
OAAI
Guerra, Matteo; Pasquer, Helene; de Oliveira, Rafael Daltro; Soret-Dulphy, Juliette; Maslah, Nabih; Zhao, Lin-Pierre; Marcault, Clemence; Cazaux, Marine; Gauthier, Nicolas; Verger, Emmanuelle; Parquet, Nathalie; Vainchenker, William; Raffoux, Emmanuel; Giraudier, Stephane; Cassinat, Bruno; Kiladjian, Jean-Jacques; Benajiba, Lina
Distinct clinico-molecular arterial and venous thrombosis scores for myeloproliferative neoplasms risk stratification
LEUKEMIA
IF13.4
2023-12-278
PRE
Pasquer, Helene; de Oliveira, Rafael Daltro; Vasseur, Loic; Soret-Dulphy, Juliette; Maslah, Nabih; Zhao, Lin-Pierre; Marcault, Clemence; Cazaux, Marine; Gauthier, Nicolas; Verger, Emmanuelle; Parquet, Nathalie; Vainchenker, William; Raffoux, Emmanuel; Ugo, Valerie; Luque Paz, Damien; Roy, Lydia; Lambert, Wayne-Corentin; Ianotto, Jean-Christophe; Lippert, Eric; Giraudier, Stephane; Cassinat, Bruno; Kiladjian, Jean-Jacques; Benajiba, Lina
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution

单细胞多组学将慢性炎症确定为TP53-mutant白血病演变的驱动因素

NATURE GENETICS
IF31.8
2023-09-0439
OAAI
Rodriguez-Meira, Alba; Norfo, Ruggiero; Wen, Sean; Chedeville, Agathe L.; Rahman, Haseeb; O'Sullivan, Jennifer; Wang, Guanlin; Louka, Eleni; Kretzschmar, Warren W.; Paterson, Aimee; Brierley, Charlotte; Martin, Jean-Edouard; Demeule, Caroline; Bashton, Matthew; Sousos, Nikolaos; Moralli, Daniela; Meem, Lamia Subha; Carrelha, Joana; Wu, Bishan; Hamblin, Angela; Guermouche, Helene; Pasquier, Florence; Marzac, Christophe; Girodon, Francois; Vainchenker, William; Drummond, Mark; Harrison, Claire; Chapman, J. Ross; Plo, Isabelle; Jacobsen, Sten Eirik W.; Psaila, Bethan; Thongjuea, Supat; Antony-Debre, Ileana; Mead, Adam J.
SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice
LEUKEMIA
IF13.4
2023-04-263
OA
Willekens, Christophe; Laplane, Lucie; Dagher, Tracy; Benlabiod, Camelia; Papadopoulos, Nicolas; Lacout, Catherine; Rameau, Philippe; Catelain, Cyril; Alfaro, Alexia; Edmond, Valerie; Signolle, Nicolas; Marchand, Valentine; Droin, Nathalie; Hoogenboezem, Remco; Schneider, Rebekka. K. K.; Penson, Alex; Abdel-Wahab, Omar; Giraudier, Stephane; Pasquier, Florence; Marty, Caroline; Plo, Isabelle; Villeval, Jean-Luc; Constantinescu, Stefan. N. N.; Porteu, Francoise; Vainchenker, William; Solary, Eric
ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis
HAEMATOLOGICA
IF7.9
2023-02-163
OAAI
Basso-Valentina, Francesca; Donada, Alessandro; Manchev, Vladimir T.; Lisetto, Manuel; Balayn, Nathalie; Martin, Jean Edouard; Muller, Delphine; Oyarzun, Cecilia Paola Marin; Duparc, Helene; Arkoun, Brahim; Cumin, Alessandro; Faivre, Lionel; Droin, Nathalie; Biunno, Ida; Pecci, Alessandro; Balduini, Alessandra; Debili, Najet; Antony-Debre, Ileana; Marty, Caroline; Vainchenker, William; Plo, Isabelle; Favier, Remi; Raslova, Hana
Biological drivers of clinical phenotype in myelofibrosis
LEUKEMIA
IF13.4
2022-11-2422
OAAI
Mascarenhas, John; Gleitz, Helene F. E.; Chifotides, Helen T.; Harrison, Claire N.; Verstovsek, Srdan; Vannucchi, Alessandro Maria; Rampal, Raajit K.; Kiladjian, Jean-Jacques; Vainchenker, William; Hoffman, Ronald; Schneider, Rebekka K.; List, Alan F.
Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2022-07-1517
OAAI
Arkoun, Brahim; Robert, Elie; Boudia, Fabien; Mazzi, Stefania; Dufour, Virginie; Siret, Aurelie; Mammasse, Yasmine; Aid, Zakia; Vieira, Matthieu; Aygun, Imanci; Aglave, Marine; Cambot, Marie; Petermann, Rachel; Souquere, Sylvie; Rameau, Philippe; Catelain, Cyril; Diot, Romain; Tachdjian, Gerard; Hermine, Olivier; Droin, Nathalie; Debili, Najet; Plo, Isabelle; Malinge, Sebastien; Soler, Eric; Raslova, Hana; Mercher, Thomas; Vainchenker, William
RETRACTED: In Vivo Monitoring of Polycythemia Vera Development Reveals Carbonic Anhydrase 1 as a Potent Therapeutic Target (Retracted Article)
BLOOD CANCER DISCOVERY
IF11.5
2022-03-151
OA
Murakami, Shohei; Barroca, Vilma; Perie, Leila; Bravard, Anne; Bernardino-Sgherri, Jacqueline; Tisserand, Amandine; Devanand, Caroline; Edmond, Valerie; Magniez, Aurelie; Bento, Sabrina Tenreira; Torres, Claire; Pasquier, Florence; Plo, Isabelle; Vainchenker, William; Villeval, Jean-Luc; Romeo, Paul-Henri; Lewandowski, Daniel
Macrophage migration inhibitory factor is overproduced through EGR1 in TET2low resting monocytes
COMMUNICATIONS BIOLOGY
IF5.1
2022-02-0317
OAAI
Pronier, Elodie; Imanci, Aygun; Selimoglu-Buet, Dorothee; Badaoui, Bouchra; Itzykson, Raphael; Roger, Thierry; Jego, Chloe; Naimo, Audrey; Francillette, Maela; Breckler, Marie; Wagner-Ballon, Orianne; Figueroa, Maria E.; Aglave, Marine; Gautheret, Daniel; Porteu, Francoise; Bernard, Olivier A.; Vainchenker, William; Delhommeau, Francois; Solary, Eric; Droin, Nathalie M.

研究方向

暂未获取到该数据
I
Isabelle Plo
H 指数:43论文数:279被引数:8,964
H
Hana Raslová
H 指数:38论文数:140被引数:8,341
N
Najet Debili
H 指数:61论文数:225被引数:1.1万
S
Stefan N. Constantinescu
H 指数:67论文数:344被引数:1.9万
É
Éric Solary
H 指数:99论文数:747被引数:4.2万
C
Caroline Marty
H 指数:41论文数:188被引数:5,609
J
Jean‐Luc Villeval
H 指数:48论文数:177被引数:1.2万
O
Olivier Bernard
H 指数:108论文数:865被引数:4.0万
N
Nathalie Droin
H 指数:60论文数:434被引数:1.6万
N
Nicole Casadevall
H 指数:61论文数:308被引数:1.7万