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Hongkui Zeng
H指数:94
被引数:5.4万
个人简介
Joined the Allen Institute in 2006 and became Executive Vice President, Director for the Brain Science group in 2020. From 2016 to 2020, she led the Structured Science Division to develop and operate high-throughput pipelines to generate large-scale datasets and tools to accelerate neuroscience discovery. Since joining the Allen Institute, she has led several research programs, including the Transgenic Technology program, the Human Cortex Gene Survey project, the Allen Mouse Brain Connectivity Atlas project, the Cell Types and Connectivity program, the Human and Mammalian Brain Cell Atlas project, and the Developmental Mouse Brain Cell Atlas project. The scholar studies neuronal diversity and connectivity in mammalian brain-wide circuits in the context of development, function and disease. Through her leadership of multidisciplinary teams, she has built research programs using transcriptomic, connectomic and multimodal approaches to characterize and classify the wide variety of cell types in the brain, laying the foundation for unraveling the cell type basis of brain function. Her work has led to many large-scale, open-access datasets and tools that have become widely adopted community resources and standards, including transgenic mouse lines, Allen Mouse Brain Connectivity Atlas, the Common Coordinate Framework (CCF), and the brain-wide transcriptomic cell type taxonomy and atlas. The scholar received her Ph.D. in molecular and cell biology from Brandeis University, where she studied the molecular mechanisms of the circadian clock in fruit flies. As a postdoctoral fellow at Massachusetts Institute of Technology, she studied the molecular and synaptic mechanisms underlying hippocampus-dependent plasticity and learning. She has received many honors, including the 2016 AWIS Award for Scientific Advancement, the 2018 Gill Transformative Investigator Award, and the 2023 Pradel Research Award from the National Academy of Sciences. The scholar is an elected member of the National Academy of Sciences and the National Academy of Medicine.
教育背景
暂无内容
工作经历
2016.01 – 2020.12
Allen Institute
2006.01 – 至今
Allen Institute
Executive Vice President, Director for the Brain Science group
荣誉奖项
- AWIS Award for Scientific Advancement（2016）｜AWIS
- Gill Transformative Investigator Award（2018）
- Pradel Research Award（2023）｜National Academy of Sciences
- Asian American Engineer of the Year (AAEOY) Award（2024）
- Elected member｜National Academy of Sciences
新生小鼠前脑的空间-时间克隆结构
Nature
IF48.5
新皮质长程抑制促进皮层同步和睡眠
Nature
IF48.5
将小鼠视觉皮层中的单细胞转录组与投射组联系起来
Nature
IF48.5
全脑拓扑结构中旋转波的协调
Science
IF45.8
小鼠基底神经节和丘脑旁丘脑核的基因架构与输入-输出组织
Psilocybin触发大规模皮质网络的活动依赖性重新布线
Cell
IF42.5
直接和间接将光遗传学转化为人类发现和疗法的路线图
理解人类和哺乳动物大脑发育的新前沿
Nature
IF48.5
转录组和空间组织学上的端脑GABA能神经元
Nature
IF48.5
小鼠视觉皮层发育过程中的连续细胞类型多样化
Nature
IF48.5
epDevAtlas：绘制早期新生小鼠脑内GABAergic细胞和小胶质细胞的图谱
Nature Communications
IF15.7
基于Transformer的面向小鼠脑部数据驱动的精细化区域发现
Nature Communications
IF15.7
基于图像变分流形技术的xIV-LDDMM工具包，用于跨尺度映射3D图像和空间组学
成像多类活动哺乳动物神经元中的高频电压动力学
Cell
IF42.5
成像行为哺乳动物多种神经元类型的高频电压动力学
Cell
IF42.5
胆碱能神经元活动通过毒蕈碱信号促进弥漫性中线胶质瘤生长
Cell
IF42.5
小鼠视觉皮层中预测的Sst转录组类型的连接组学
NATURE
IF48.5
单神经元连接性对小鼠大脑中的细胞亚型进行分类
Nature Methods
IF32.1
通过全脑形态计量学在多个尺度上的神经元多样性和刻板印象
NATURE COMMUNICATIONS
IF15.7
