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R

Roland A. Cooper

Dominican University of California
H指数:34
被引数:5,930

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Potent acridone antimalarial against all three life stages of Plasmodium

针对疟原虫的所有三个生命阶段的有效acridone抗疟药

Nature Communications
IF15.7
2026-04-140
OAAI
Papireddy Kancharla; Rozalia A. Dodean; Yuexin Li; Xiaowei Zhang; Sean Kelly; Jordan Charlton; Angely J. Binauhan; Kimberly Navarrete; Laurize Garcia; Jianbing Mu; Jinghua Lu; Diana Caridha; Michael S. Madejczyk; Xiannu Jin; William E. Dennis; Karl Kudyba; Sharon McEnearney; Patricia J. Lee; Cameron Blount; Jesse DeLuca; Chau Vuong; Kristina Pannone; Hieu T. Dinh; Kennedy Mdaki; Susan Leed; Monica L. Martin; Brandon S. Pybus; Geoffrey C. Chin; Anongruk Chim-Ong; Liwang Cui; Tarrick Qahash; Douglas A. Shoue; Michael T. Ferdig; Frank P. Mockenhaupt; Welmoed van Loon; Jules M. Ndoli; Heather Kudyba; Joel Vega-Rodriguez; Martin Okitwi; Oriana Kreutzfeld; Cristina Docan; Carol Green; Ying Liu; Aaron Agulay; Jon Mirsalis; Sarah N. Farrell; Alexandra S. Probst; Aaron Nilsen; P. Holland Alday; J. Stone Doggett; Geoffrey I. McFadden; Christopher D. Goodman; Flaminia Catteruccia; Philip J. Rosenthal; Michael K. Riscoe; Roland A. Cooper; Alison Roth; Jane X. Kelly
Optimization of Prodiginines as Single-Dose Curative Antimalarials

单剂量根治性抗疟药Prodiginines的优化

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-11-010
PRE
Kumar, Amrendra; Li, Yuexin; Zhang, Xiaowei; Gaddam, Mahesh; Caridha, Diana; Madejczyk, Michael S.; Jin, Xiannu; Dennis, William E.; Chetree, Ravi; Blount, Cameron; DeLuca, Jesse; Vuong, Chau; Kudyba, Karl; Roncal, Norma; Ashraf, Kutub; Lee, Patricia J.; Pannone, Kristina; Leed, Susan; Dinh, Hieu T.; Mdaki, Kennedy; Navarrete, Kimberly; Charlton, Jordan; Binauhan, Angely J.; Qahash, Tarrick; Kibe, Kevin Mugambi; Shoue, Douglas A.; Checkley, Lisa; Ferdig, Michael T.; Chim-Ong, Anongruk; Cui, Liwang; Orena, Stephen; Byaruhanga, Oswald; Assimwe, Jackson; Tibagambirwa, Innocent; Chithanna, Sivanna; Dodean, Rozalia A.; Legac, Jennifer; Kreutzfeld, Oriana; Rosenthal, Philip J.; Cooper, Roland A.; Reynolds, Kevin A.; Roth, Alison; Kelly, Jane X.; Kancharla, Papireddy
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

在青蒿素部分耐药背景下鉴定下一代抗疟三氧杂环戊烷类药物

Science Advances
IF12.5
2025-08-080
OA
Matthew T. Klope; Poulami Talukder; Brian R. Blank; Sevil Chelebieva; Jun Chen; Shaun D. Fontaine; Ryan L. Gonciarz; Priyadarshini Jaishankar; Grace J. Lee; Jennifer Legac; Vineet Mathur; Avani Narayan; Martin Okitwi; Stephen Orena; Nicholas S. Settineri; Juan A. Tapia; Yoweri Taremwa; Patrick K. Tumwebaze; Aswathy Vinod; Jeremy N. Burrows; Philip J. Rosenthal; Roland A. Cooper; Adam R. Renslo
Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Plasmodium falciparum蛋白激酶6和血红素晶体的形成被一种具有抗疟疾活性的II型人源激酶抑制剂所抑制

Cell Chemical Biology
IF7.2
2025-07-070
PRE
Flore Nardella; Tiantian Jiang; Lushun Wang; Monica J. Bohmer; Subhoja Chakraborty; John Okombo; Jaeson Calla; Tatiane Macedo Silva; Samuel Pazicky; Jianwei Che; Jin Jeon; Evie Vincent; Nonlawat Boonyalai; Rachael Coyle; Mairi J. Buchanan; Samuel Schaefer; Daisy Chen; Amaan Khan; Emily Mayville; Mariana Laureano De Souza; Mayland Treat; Jordan Charlton; Patrick K. Tumwebaze; Seth Tjia; Lukas Montejo; Karen Cover; Philip J. Rosenthal; Roland A. Cooper; Zbynek Bozdech; Marcus C.S. Lee; Ratna Chakrabarti; Sanjay A. Desai; David A. Fidock; Jinhua Wang; Nathanael S. Gray; Elizabeth A. Winzeler; Debopam Chakrabarti
Development of Next-Generation Antimalarial Acridones with Radical Cure Potential

下一代具有自由基治愈潜力的抗疟喹诺酮类化合物的发展

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-04-030
PRE
Dodean, Rozalia A.; Li, Yuexin; Zhang, Xiaowei; Caridha, Diana; Madejczyk, Michael S.; Jin, Xiannu; Dennis, William E.; Chetree, Ravi; Kudyba, Karl; Mcenearney, Sharon; Lee, Patricia J.; Blount, Cameron; Deluca, Jesse; Vuong, Chau; Pannone, Kristina; Dinh, Hieu T.; Mdaki, Kennedy; Leed, Susan; Martin, Monica L.; Pybus, Brandon S.; Pou, Sovitj; Winter, Rolf W.; Liebman, Katherine M.; Williams, Rachel; Kumar, Amrendra; Chim-Ong, Anongruk; Cui, Liwang; Orena, Stephen; Assimwe, Jackson; Tibagambirwa, Innocent; Byaruhanga, Oswald; Angutoko, Patrick; Legac, Jennifer; Kreutzfeld, Oriana; Rosenthal, Philip J.; Cooper, Roland A.; Nilsen, Aaron; Riscoe, Michael K.; Roth, Alison; Kancharla, Papireddy; Kelly, Jane X.
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission
SCIENCE ADVANCES
IF12.5
2024-12-060
OAAI
Gomez-Gonzalez, Paula-Josefina; Gupta, Antima; Drought, Laura G.; Patel, Avnish; Okombo, John; van der Watt, Mariette; Walker-Gray, Ryan; Schindler, Kyra A.; Burkhard, Anna Y.; Yeo, Tomas; Narwal, Sunil K.; Bloxham, Talia S.; Flueck, Christian; Walker, Eloise M.; Rey, Joshua A.; Fairhurst, Kate J.; Reader, Janette; Park, Heekuk; Pollard, Harry G.; Stewart, Lindsay B.; Brandner-Garrod, Luke; Kristan, Mojca; Sterk, Geert-Jan; van Nuland, Youri M.; Manko, Emilia; van Schalkwyk, Donelly A.; Zheng, Yang; Leurs, Rob; Dechering, Koen J.; Aguiar, Anna Caroline C.; Guido, Rafael V. C.; Pereira, Dhelio B.; Tumwebaze, Patrick K.; Nosbya, Samuel L.; Rosenthal, Philip J.; Cooper, Roland A.; Palmer, Mike; Parkinson, Tanya; Burrows, Jeremy N.; Uhlemann, Anne-Catrin; Birkholtz, Lyn-Marie; Small-Saunders, Jennifer L.; Duffy, James; Fidock, David A.; Brown, Alan; Gardner, Mark; Baker, David A.
The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates

延长恢复环阶段存活试验是新鲜恶性疟原虫分离株青蒿素敏感性表型的可扩展替代方法

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2024-12-050
PRE
Okitwi, Martin; Shoue, Douglas A.; Checkley, Lisa A.; Orena, Stephen; Ceja, Frida G.; Taremwa, Yoweri; Tumwebaze, Patrick K.; Katairo, Thomas; Byaruhanga, Oswald; Sievert, Mackenzie A. C.; Garg, Shreeya; Kreutzfeld, Oriana K.; Legac, Jennifer; Bailey, Jeffrey A.; Nsobya, Sam L.; Conrad, Melissa D.; Rosenthal, Philip J.; Ferdig, Michael T.; Cooper, Roland A.
Tambjamines as Fast-Acting Multistage Antimalarials
ACS INFECTIOUS DISEASES
IF3.8
2024-11-110
PRE
Kumar, Amrendra; Li, Yuexin; Dodean, Rozalia A.; Roth, Alison; Caridha, Diana; Madejczyk, Michael S.; Jin, Xiannu; Dennis, William E.; Lee, Patricia J.; Pybus, Brandon S.; Martin, Monica; Pannone, Kristina; Dinh, Hieu T.; Blount, Cameron; Chetree, Ravi; Deluca, Jesse; Evans, Martin; Nadeau, Robert; Vuong, Chau; Leed, Susan; Black, Chad; Sousa, Jason; Nolan, Christina; Ceja, Frida G.; Rasmussen, Stephanie A.; Tumwebaze, Patrick K.; Rosenthal, Philip J.; Cooper, Roland A.; Rottmann, Matthias; Orjuela-Sanchez, Pamela; Meister, Stephan; Winzeler, Elizabeth A.; Delves, Michael J.; Matthews, Holly; Baum, Jake; Kirby, Robert W.; Burrows, Jeremy N.; Duffy, James; Peyton, David H.; Reynolds, Kevin A.; Kelly, Jane X.; Kancharla, Papireddy
Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates

乌干达恶性疟原虫分离株对ganaplacide的离体敏感性和潜在抗性介质的多样性

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2024-09-040
PRE
Kreutzfeld, Oriana; Orena, Stephen; Okitwi, Martin; Tumwebaze, Patrick K.; Byaruhanga, Oswald; Katairo, Thomas; Conrad, Melissa D.; Legac, Jennifer; Garg, Shreeya; Crudale, Rebecca; Aydemir, Ozkan; Giesbrecht, David; Nsobya, Samuel L.; Blasco, Benjamin; Duffey, Maelle; Rouillier, Melanie; Bailey, Jeffrey A.; Cooper, Roland A.; Rosenthal, Philip J.
Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso

布基纳法索bobo-dioulasso恶性疟原虫的离体药物敏感性和耐药性介导的遗传多态性

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2024-04-031
OA
Some, A. Fabrice; Conrad, Melissa D.; Kabre, Zachari; Fofana, Aminata; Yerbanga, R. Serge; Bazie, Thomas; Neya, Catherine; Some, Myreille; Kagambega, Tegawinde Josue; Legac, Jenny; Garg, Shreeya; Bailey, Jeffrey A.; Ouedraogo, Jean-Bosco; Rosenthal, Philip J.; Cooper, Roland A.
Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases

发现对人类激酶具有选择性的有效抗疟疾II型激酶抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-120
PRE
Wang, Lushun; Bohmer, Monica J.; Wang, Jinhua; Nardella, Flore; Calla, Jaeson; De Souza, Mariana Laureano; Schindler, Kyra A.; Montejo, Lukas; Mittal, Nimisha; Rocamora, Frances; Treat, Mayland; Charlton, Jordan T.; Tumwebaze, Patrick K.; Rosenthal, Philip J.; Cooper, Roland A.; Chakrabarti, Ratna; Winzeler, Elizabeth A.; Chakrabarti, Debopam; Gray, Nathanael S.
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda

乌干达疟原虫对青蒿素部分耐药性的演变

NEW ENGLAND JOURNAL OF MEDICINE
IF78.5
2023-08-2467
OA
Conrad, Melissa D.; Asua, Victor; Garg, Shreeya; Giesbrecht, David; Niare, Karamoko; Smith, Sawyer; Namuganga, Jane F.; Katairo, Thomas; Legac, Jennifer; Crudale, Rebecca M.; Tumwebaze, Patrick K.; Nsobya, Samuel L.; Cooper, Roland A.; Kamya, Moses R.; Dorsey, Grant; Bailey, Jeffrey A.; Rosenthal, Philip J.
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
MICROBIOLOGY SPECTRUM
IF3.8
2023-06-154
OAAI
Kreutzfeld, Oriana; Tumwebaze, Patrick K.; Okitwi, Martin; Orena, Stephen; Byaruhanga, Oswald; Katairo, Thomas; Conrad, Melissa D.; Rasmussen, Stephanie A.; Legac, Jennifer; Aydemir, Ozkan; Giesbrecht, David; Forte, Barbara; Campbell, Peter; Smith, Alasdair; Kano, Hiroki; Nsobya, Samuel L.; Blasco, Benjamin; Duffey, Maelle; Bailey, Jeffrey A.; Cooper, Roland A.; Rosenthal, Philip J.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors-Part II
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-01-113
PRE
Zhang, Hao; Ginn, John; Zhan, Wenhu; Leung, Annie; Liu, Yi J.; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Michino, Mayako; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K.; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J.; Cooper, Roland A.; Liverton, Nigel; Foley, Michael; Meinke, Peter T.; Nathan, Carl F.; Kirkman, Laura A.; Lin, Gang
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors

乌干达恶性疟原虫分离株对蛋白酶体抑制剂的敏感性

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2022-10-185
OA
Garg, Shreeya; Kreutzfeld, Oriana; Chelebieva, Sevil; Tumwebaze, Patrick K.; Byaruhanga, Oswald; Okitwi, Martin; Orena, Stephen; Katairo, Thomas; Nsobya, Samuel L.; Conrad, Melissa D.; Aydemir, Ozkan; Legac, Jennifer; Gould, Alexandra E.; Bayles, Brett R.; Bailey, Jeffrey A.; Duffey, Maelle; Lin, Gang; Kirkman, Laura A.; Cooper, Roland A.; Rosenthal, Philip J.
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
NATURE COMMUNICATIONS
IF15.7
2022-04-2021
OAAI
de Vries, Laura E.; Jansen, Patrick A. M.; Barcelo, Catalina; Munro, Justin; Verhoef, Julie M. J.; Pasaje, Charisse Flerida A.; Rubiano, Kelly; Striepen, Josefine; Abla, Nada; Berning, Luuk; Bolscher, Judith M.; Demarta-Gatsi, Claudia; Henderson, Rob W. M.; Huijs, Tonnie; Koolen, Karin M. J.; Tumwebaze, Patrick K.; Yeo, Tomas; Aguiar, Anna C. C.; Angulo-Barturen, Inigo; Churchyard, Alisje; Baum, Jake; Fernandez, Benigno Crespo; Fuchs, Aline; Gamo, Francisco-Javier; Guido, Rafael V. C.; Jimenez-Diaz, Maria Belen; Pereira, Dhelio B.; Rochford, Rosemary; Roesch, Camille; Sanz, Laura M.; Trevitt, Graham; Witkowski, Benoit; Wittlin, Sergio; Cooper, Roland A.; Rosenthal, Philip J.; Sauerwein, Robert W.; Schalkwijk, Joost; Hermkens, Pedro H. H.; Bonnert, Roger, V; Campo, Brice; Fidock, David A.; Llinas, Manuel; Niles, Jacquin C.; Kooij, Taco W. A.; Dechering, Koen J.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-03-0116
OAAI
Taft, Benjamin R.; Yokokawa, Fumiaki; Kirrane, Tom; Mata, Anne-Catherine; Huang, Richard; Blaquiere, Nicole; Waldron, Grace; Zou, Bin; Simon, Oliver; Vankadara, Subramanyam; Chan, Wai Ling; Ding, Mei; Sim, Sandra; Straimer, Judith; Guiguemde, Armand; Lakshminarayana, Suresh B.; Jain, Jay Prakash; Bodenreider, Christophe; Thompson, Christopher; Lanshoeft, Christian; Shu, Wei; Fang, Eric; Qumber, Jafri; Chan, Katherine; Pei, Luying; Chen, Yen-Liang; Schulz, Hanna; Lim, Jessie; Abas, Siti Nurdiana; Ang, Xiaoman; Liu, Yugang; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Javier Gamo, Francisco; Crespo-Fernandez, Benigno; Rosenthal, Philip J.; Cooper, Roland A.; Tumwebaze, Patrick; Campos Aguiar, Anna Caroline; Campo, Brice; Campbell, Simon; Wagner, Jurgen; Diagana, Thierry T.; Sarko, Christopher

研究方向

暂未获取到该数据
P
Philip J. Rosenthal
H 指数:100论文数:699被引数:3.3万
P
Patrick K. Tumwebaze
H 指数:21论文数:60被引数:1,706
M
Melissa D. Conrad
H 指数:36论文数:123被引数:4,964
J
Jennifer Legac
H 指数:24论文数:85被引数:2,093
S
Samuel L. Nsobya
H 指数:36论文数:140被引数:4,127
O
Oswald Byaruhanga
H 指数:8论文数:46被引数:558
S
Stephen Orena
H 指数:15论文数:60被引数:1,599
T
Thomas Katairo
H 指数:11论文数:61被引数:780
M
Martin Okitwi
H 指数:7论文数:33被引数:324
D
David A. Fidock
H 指数:95论文数:427被引数:3.3万