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P

Patrick K. Tumwebaze

infectious diseases research collaboration
H指数:21
被引数:1,706

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Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

在青蒿素部分耐药背景下鉴定下一代抗疟三氧杂环戊烷类药物

Science Advances
IF12.5
2025-08-080
OA
Matthew T. Klope; Poulami Talukder; Brian R. Blank; Sevil Chelebieva; Jun Chen; Shaun D. Fontaine; Ryan L. Gonciarz; Priyadarshini Jaishankar; Grace J. Lee; Jennifer Legac; Vineet Mathur; Avani Narayan; Martin Okitwi; Stephen Orena; Nicholas S. Settineri; Juan A. Tapia; Yoweri Taremwa; Patrick K. Tumwebaze; Aswathy Vinod; Jeremy N. Burrows; Philip J. Rosenthal; Roland A. Cooper; Adam R. Renslo
Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

Plasmodium falciparum蛋白激酶6和血红素晶体的形成被一种具有抗疟疾活性的II型人源激酶抑制剂所抑制

Cell Chemical Biology
IF7.2
2025-07-070
PRE
Flore Nardella; Tiantian Jiang; Lushun Wang; Monica J. Bohmer; Subhoja Chakraborty; John Okombo; Jaeson Calla; Tatiane Macedo Silva; Samuel Pazicky; Jianwei Che; Jin Jeon; Evie Vincent; Nonlawat Boonyalai; Rachael Coyle; Mairi J. Buchanan; Samuel Schaefer; Daisy Chen; Amaan Khan; Emily Mayville; Mariana Laureano De Souza; Mayland Treat; Jordan Charlton; Patrick K. Tumwebaze; Seth Tjia; Lukas Montejo; Karen Cover; Philip J. Rosenthal; Roland A. Cooper; Zbynek Bozdech; Marcus C.S. Lee; Ratna Chakrabarti; Sanjay A. Desai; David A. Fidock; Jinhua Wang; Nathanael S. Gray; Elizabeth A. Winzeler; Debopam Chakrabarti
Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2025-04-010
OAAI
Proellochs, Nicholas I.; Andolina, Chiara; Ramjith, Jordache; Stoter, Rianne; van Gemert, Geert-Jan; Graumans, Wouter; Campino, Susana; Vanheer, Leen N.; Okitwi, Martin; Tumwebaze, Patrick K.; Conrad, Melissa D.; Clark, Taane G.; Fidock, David A.; Menard, Didier; Mok, Sachel; Bousema, Teun
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission
SCIENCE ADVANCES
IF12.5
2024-12-060
OAAI
Gomez-Gonzalez, Paula-Josefina; Gupta, Antima; Drought, Laura G.; Patel, Avnish; Okombo, John; van der Watt, Mariette; Walker-Gray, Ryan; Schindler, Kyra A.; Burkhard, Anna Y.; Yeo, Tomas; Narwal, Sunil K.; Bloxham, Talia S.; Flueck, Christian; Walker, Eloise M.; Rey, Joshua A.; Fairhurst, Kate J.; Reader, Janette; Park, Heekuk; Pollard, Harry G.; Stewart, Lindsay B.; Brandner-Garrod, Luke; Kristan, Mojca; Sterk, Geert-Jan; van Nuland, Youri M.; Manko, Emilia; van Schalkwyk, Donelly A.; Zheng, Yang; Leurs, Rob; Dechering, Koen J.; Aguiar, Anna Caroline C.; Guido, Rafael V. C.; Pereira, Dhelio B.; Tumwebaze, Patrick K.; Nosbya, Samuel L.; Rosenthal, Philip J.; Cooper, Roland A.; Palmer, Mike; Parkinson, Tanya; Burrows, Jeremy N.; Uhlemann, Anne-Catrin; Birkholtz, Lyn-Marie; Small-Saunders, Jennifer L.; Duffy, James; Fidock, David A.; Brown, Alan; Gardner, Mark; Baker, David A.
The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates

延长恢复环阶段存活试验是新鲜恶性疟原虫分离株青蒿素敏感性表型的可扩展替代方法

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2024-12-050
PRE
Okitwi, Martin; Shoue, Douglas A.; Checkley, Lisa A.; Orena, Stephen; Ceja, Frida G.; Taremwa, Yoweri; Tumwebaze, Patrick K.; Katairo, Thomas; Byaruhanga, Oswald; Sievert, Mackenzie A. C.; Garg, Shreeya; Kreutzfeld, Oriana K.; Legac, Jennifer; Bailey, Jeffrey A.; Nsobya, Sam L.; Conrad, Melissa D.; Rosenthal, Philip J.; Ferdig, Michael T.; Cooper, Roland A.
Tambjamines as Fast-Acting Multistage Antimalarials
ACS INFECTIOUS DISEASES
IF3.8
2024-11-110
PRE
Kumar, Amrendra; Li, Yuexin; Dodean, Rozalia A.; Roth, Alison; Caridha, Diana; Madejczyk, Michael S.; Jin, Xiannu; Dennis, William E.; Lee, Patricia J.; Pybus, Brandon S.; Martin, Monica; Pannone, Kristina; Dinh, Hieu T.; Blount, Cameron; Chetree, Ravi; Deluca, Jesse; Evans, Martin; Nadeau, Robert; Vuong, Chau; Leed, Susan; Black, Chad; Sousa, Jason; Nolan, Christina; Ceja, Frida G.; Rasmussen, Stephanie A.; Tumwebaze, Patrick K.; Rosenthal, Philip J.; Cooper, Roland A.; Rottmann, Matthias; Orjuela-Sanchez, Pamela; Meister, Stephan; Winzeler, Elizabeth A.; Delves, Michael J.; Matthews, Holly; Baum, Jake; Kirby, Robert W.; Burrows, Jeremy N.; Duffy, James; Peyton, David H.; Reynolds, Kevin A.; Kelly, Jane X.; Kancharla, Papireddy
Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates

乌干达恶性疟原虫分离株对ganaplacide的离体敏感性和潜在抗性介质的多样性

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2024-09-040
PRE
Kreutzfeld, Oriana; Orena, Stephen; Okitwi, Martin; Tumwebaze, Patrick K.; Byaruhanga, Oswald; Katairo, Thomas; Conrad, Melissa D.; Legac, Jennifer; Garg, Shreeya; Crudale, Rebecca; Aydemir, Ozkan; Giesbrecht, David; Nsobya, Samuel L.; Blasco, Benjamin; Duffey, Maelle; Rouillier, Melanie; Bailey, Jeffrey A.; Cooper, Roland A.; Rosenthal, Philip J.
Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases

发现对人类激酶具有选择性的有效抗疟疾II型激酶抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-120
PRE
Wang, Lushun; Bohmer, Monica J.; Wang, Jinhua; Nardella, Flore; Calla, Jaeson; De Souza, Mariana Laureano; Schindler, Kyra A.; Montejo, Lukas; Mittal, Nimisha; Rocamora, Frances; Treat, Mayland; Charlton, Jordan T.; Tumwebaze, Patrick K.; Rosenthal, Philip J.; Cooper, Roland A.; Chakrabarti, Ratna; Winzeler, Elizabeth A.; Chakrabarti, Debopam; Gray, Nathanael S.
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda

乌干达疟原虫对青蒿素部分耐药性的演变

NEW ENGLAND JOURNAL OF MEDICINE
IF78.5
2023-08-2467
OA
Conrad, Melissa D.; Asua, Victor; Garg, Shreeya; Giesbrecht, David; Niare, Karamoko; Smith, Sawyer; Namuganga, Jane F.; Katairo, Thomas; Legac, Jennifer; Crudale, Rebecca M.; Tumwebaze, Patrick K.; Nsobya, Samuel L.; Cooper, Roland A.; Kamya, Moses R.; Dorsey, Grant; Bailey, Jeffrey A.; Rosenthal, Philip J.
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline
MICROBIOLOGY SPECTRUM
IF3.8
2023-06-154
OAAI
Kreutzfeld, Oriana; Tumwebaze, Patrick K.; Okitwi, Martin; Orena, Stephen; Byaruhanga, Oswald; Katairo, Thomas; Conrad, Melissa D.; Rasmussen, Stephanie A.; Legac, Jennifer; Aydemir, Ozkan; Giesbrecht, David; Forte, Barbara; Campbell, Peter; Smith, Alasdair; Kano, Hiroki; Nsobya, Samuel L.; Blasco, Benjamin; Duffey, Maelle; Bailey, Jeffrey A.; Cooper, Roland A.; Rosenthal, Philip J.
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors-Part II
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-01-113
PRE
Zhang, Hao; Ginn, John; Zhan, Wenhu; Leung, Annie; Liu, Yi J.; Toita, Akinori; Okamoto, Rei; Wong, Tzu-Tshin; Imaeda, Toshihiro; Hara, Ryoma; Michino, Mayako; Yukawa, Takafumi; Chelebieva, Sevil; Tumwebaze, Patrick K.; Vendome, Jeremie; Beuming, Thijs; Sato, Kenjiro; Aso, Kazuyoshi; Rosenthal, Philip J.; Cooper, Roland A.; Liverton, Nigel; Foley, Michael; Meinke, Peter T.; Nathan, Carl F.; Kirkman, Laura A.; Lin, Gang
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors

乌干达恶性疟原虫分离株对蛋白酶体抑制剂的敏感性

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2022-10-185
OA
Garg, Shreeya; Kreutzfeld, Oriana; Chelebieva, Sevil; Tumwebaze, Patrick K.; Byaruhanga, Oswald; Okitwi, Martin; Orena, Stephen; Katairo, Thomas; Nsobya, Samuel L.; Conrad, Melissa D.; Aydemir, Ozkan; Legac, Jennifer; Gould, Alexandra E.; Bayles, Brett R.; Bailey, Jeffrey A.; Duffey, Maelle; Lin, Gang; Kirkman, Laura A.; Cooper, Roland A.; Rosenthal, Philip J.
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
NATURE COMMUNICATIONS
IF15.7
2022-04-2021
OAAI
de Vries, Laura E.; Jansen, Patrick A. M.; Barcelo, Catalina; Munro, Justin; Verhoef, Julie M. J.; Pasaje, Charisse Flerida A.; Rubiano, Kelly; Striepen, Josefine; Abla, Nada; Berning, Luuk; Bolscher, Judith M.; Demarta-Gatsi, Claudia; Henderson, Rob W. M.; Huijs, Tonnie; Koolen, Karin M. J.; Tumwebaze, Patrick K.; Yeo, Tomas; Aguiar, Anna C. C.; Angulo-Barturen, Inigo; Churchyard, Alisje; Baum, Jake; Fernandez, Benigno Crespo; Fuchs, Aline; Gamo, Francisco-Javier; Guido, Rafael V. C.; Jimenez-Diaz, Maria Belen; Pereira, Dhelio B.; Rochford, Rosemary; Roesch, Camille; Sanz, Laura M.; Trevitt, Graham; Witkowski, Benoit; Wittlin, Sergio; Cooper, Roland A.; Rosenthal, Philip J.; Sauerwein, Robert W.; Schalkwijk, Joost; Hermkens, Pedro H. H.; Bonnert, Roger, V; Campo, Brice; Fidock, David A.; Llinas, Manuel; Niles, Jacquin C.; Kooij, Taco W. A.; Dechering, Koen J.
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-03-0116
OAAI
Taft, Benjamin R.; Yokokawa, Fumiaki; Kirrane, Tom; Mata, Anne-Catherine; Huang, Richard; Blaquiere, Nicole; Waldron, Grace; Zou, Bin; Simon, Oliver; Vankadara, Subramanyam; Chan, Wai Ling; Ding, Mei; Sim, Sandra; Straimer, Judith; Guiguemde, Armand; Lakshminarayana, Suresh B.; Jain, Jay Prakash; Bodenreider, Christophe; Thompson, Christopher; Lanshoeft, Christian; Shu, Wei; Fang, Eric; Qumber, Jafri; Chan, Katherine; Pei, Luying; Chen, Yen-Liang; Schulz, Hanna; Lim, Jessie; Abas, Siti Nurdiana; Ang, Xiaoman; Liu, Yugang; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Javier Gamo, Francisco; Crespo-Fernandez, Benigno; Rosenthal, Philip J.; Cooper, Roland A.; Tumwebaze, Patrick; Campos Aguiar, Anna Caroline; Campo, Brice; Campbell, Simon; Wagner, Jurgen; Diagana, Thierry T.; Sarko, Christopher
Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
IF4.5
2021-09-172
OA
Kreutzfeld, Oriana; Rasmussen, Stephanie A.; Ramanathan, Aarti A.; Tumwebaze, Patrick K.; Byaruhanga, Oswald; Katairo, Thomas; Asua, Victor; Okitwi, Martin; Orena, Stephen; Legac, Jennifer; Conrad, Melissa D.; Nsobya, Samuel L.; Aydemir, Ozkan; Bailey, Jeffrey; Duffey, Maelle; Bayles, Brett R.; Vaidya, Akhil B.; Cooper, Roland A.; Rosenthal, Philip J.
Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates

乌干达恶性疟原虫分离株对与遗传多态性相关的二氢叶酸还原酶抑制剂的易感性降低

JOURNAL OF INFECTIOUS DISEASES
IF4.5
2021-08-307
OA
Kreutzfeld, Oriana; Tumwebaze, Patrick K.; Byaruhanga, Oswald; Katairo, Thomas; Okitwi, Martin; Orena, Stephen; Rasmussen, Stephanie A.; Legac, Jennifer; Conrad, Melissa D.; Nsobya, Sam L.; Aydemir, Ozkan; Bailey, Jeffrey A.; Duffey, Maelle; Cooper, Roland A.; Rosenthal, Philip J.

研究方向

暂未获取到该数据
P
Philip J. Rosenthal
H 指数:100论文数:699被引数:3.3万
R
Roland A. Cooper
H 指数:34论文数:91被引数:5,930
M
Melissa D. Conrad
H 指数:36论文数:123被引数:4,964
S
Samuel L. Nsobya
H 指数:36论文数:140被引数:4,127
J
Jennifer Legac
H 指数:24论文数:85被引数:2,093
O
Oswald Byaruhanga
H 指数:8论文数:46被引数:558
T
Thomas Katairo
H 指数:11论文数:61被引数:780
M
Martin Okitwi
H 指数:7论文数:33被引数:324
S
Stephen Orena
H 指数:15论文数:60被引数:1,599
J
Jeffrey A. Bailey
H 指数:57论文数:413被引数:4.3万