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F

Fabian Barthels

johannes gutenberg university of mainz

H指数:13

被引数:566

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Direct-to-Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery

IF3.4

2026-02-251

OAAI

Nanoscale Direct-to-Biology Optimization and Structural Insights into Selective S. aureus TrmD Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-12-010

PRE

Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole–nicotinamide chemotype

基于结构指导的甲基转移酶样3（METTL3）蛋白水解靶向嵌合体（PROTAC）的设计，并整合了吲哚-烟酰胺化学骨架

IF3.6

2025-08-220

OA

Parallel Synthesis of 5’-Amino-5’-deoxy-adenosine Derivatives for Focused Chemical Space Exploration and their Application as Methyltransferase Inhibitors

5’-氨基-5’-脱氧-腺苷衍生物的平行合成，用于靶向化学空间探索及其作为甲基转移酶抑制剂的应

IF3.6

2025-08-140

OA

DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site

DNA编码库筛选发现靶向隐匿别构结合位点的强效DNMT2抑制剂

IF4.1

2025-08-050

OA

A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors

COMMUNICATIONS CHEMISTRY

IF6.2

2025-02-030

OAAI

Nanomole Scale Screening of Fluorescent RNA-Methyltransferase Probes Enables the Discovery of METTL1 Inhibitors

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2024-10-240

OAAI

Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L

IF13.1

2023-10-033

OAAI

The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and 19F NMR

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-10-011

PRE

Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-07-281

OA

Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L

IF13.1

2023-04-244

OAAI

Hic Sunt Dracones: Molecular Docking in Uncharted Territories with Structures from AlphaFold2 and RoseTTAfold

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2023-03-0810

PRE

Designing photoaffinity tool compounds for the investigation of the DENV NS2B-NS3 protease allosteric binding pocket

RSC MEDICINAL CHEMISTRY

IF3.6

2023-01-014

PRE

Non-covalent dyes in microscale thermophoresis for studying RNA ligand interactions and modifications

CHEMICAL SCIENCE

IF7.4

2023-01-011

OAAI

2-Sulfonylpyrimidines as Privileged Warheads for the Development of S. aureus Sortase A Inhibitors

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2022-01-0311

OAAI

SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-10-0133

PREAI

Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-08-1129

PREAI

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics

IF4.6

2020-04-2825

OAAI

Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives

ORGANIC LETTERS

IF5

2020-03-263

PREAI

Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A

IF3.4

2020-03-2530

OA