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N

Neil P. Grimster

oncology r&d, astrazeneca, waltham, ma 02451, usa
H指数:21
被引数:3,930

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Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors

合成化学使一系列作为HPK1抑制剂的吡唑的发现和开发成为可能

RSC Med. Chem.
IF3.6
2025-08-140
PRE
Anthony J. Metrano; Lucas A. Morrill; Gayathri Bommakanti; Robert Casella; Steve Cook; Randolph A. Escobar; Kathryn A. Giblin; Eric Gosselin; Tyler Grebe; Niresh Hariparsad; Rachel Howells; Gillian M. Lamont; Deanna A. Mele; Alexander Pflug; Theresa A. Proia; Hadi Rezaei; Magdalena Richter; Ryan Richards; Maryann San Martin; Marianne Schimpl; Alwin G. Schuller; Li Sha; James E. Sheppeck, II; Kun Song; Haoran Tang; David J. Wagner; Jianyan Wang; Allan Wu; Dedong Wu; Ye Wu; Kevin Xu; Minwei Ye; Jason D. Shields; Neil P. Grimster
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor

吡嗪羧酰胺AZ3246的发现与优化：一种选择性HPK1抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-02-102
PRE
Shields, Jason D.; Baker, David; Balazs, Amber Y. S.; Bommakanti, Gayathri; Casella, Robert; Cao, Shenggen; Cook, Steve; Escobar, Randolph A.; Fawell, Stephen; Gibbons, Francis D.; Giblin, Kathryn A.; Goldberg, Frederick W.; Gosselin, Eric; Grebe, Tyler; Hariparsad, Niresh; Hatoum-Mokdad, Holia; Howells, Rachel; Hughes, Samantha J.; Jackson, Anne; Reddy, Iswarya Karapa; Kettle, Jason G.; Lamont, Gillian M.; Lamont, Scott; Li, Min; Lill, Sten O. Nilsson; Mele, Deanna A.; Metrano, Anthony J.; Mfuh, Adelphe M.; Morrill, Lucas A.; Peng, Bo; Pflug, Alexander; Proia, Theresa A.; Rezaei, Hadi; Richards, Ryan; Richter, Magdalena; Robbins, Kevin J.; San Martin, Maryann; Schimpl, Marianne; Schuller, Alwin G.; Sha, Li; Shen, Minhui; Sheppeck, James E.; Singh, Meha; Stokes, Stephen; Song, Kun; Sun, Yuanyuan; Tang, Haoran; Wagner, David J.; Wang, Jianyan; Wang, Yanjun; Wilson, David M.; Wu, Allan; Wu, Chengyan; Wu, Dedong; Wu, Ye; Xu, Kevin; Yang, Yue; Yao, Tieguang; Ye, Minwei; Zhang, Andrew X.; Zhang, Hui; Zhai, Xiang; Zhou, Yanxiao; Ziegler, Robert E.; Grimster, Neil P.
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-120
PRE
Quinn, Taylor R.; Giblin, Kathryn A.; Thomson, Clare; Boerth, Jeffrey A.; Bommakanti, Gayathri; Braybrooke, Erin; Chan, Christina; Chinn, Alex J.; Code, Erin; Cui, Caifeng; Fan, Yukai; Grimster, Neil P.; Kohara, Keishi; Lamb, Michelle L.; Ma, Lina; Mfuh, Adelphe M.; Robb, Graeme R.; Robbins, Kevin J.; Schimpl, Marianne; Tang, Haoran; Ware, Jamie; Wrigley, Gail L.; Xue, Lin; Zhang, Yun; Zhu, Huimin; Hughes, Samantha J.
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-163
PRE
Mfuh, Adelphe M.; Boerth, Jeffrey A.; Bommakanti, Gayathri; Chan, Christina; Chinn, Alex J.; Code, Erin; Fricke, Patrick J.; Giblin, Kathryn A.; Gohlke, Andrea; Hansel, Catherine; Hariparsad, Niresh; Hughes, Samantha J.; Jin, Meizhong; Kantae, Vasudev; Kavanagh, Stefan L.; Lamb, Michelle L.; Lane, Jordan; Moore, Rachel; Puri, Taranee; Quinn, Taylor R.; Reddy, Iswarya; Robb, Graeme R.; Robbins, Kevin J.; Rodrigo, Miguel Gancedo; Schimpl, Marianne; Singh, Baljinder; Singh, Meha; Tang, Haoran; Thomson, Clare; Walsh, Jarrod J.; Ware, Jamie; Watson, Iain D. G.; Ye, Min-Wei; Wrigley, Gail L.; Zhang, Andrew X.; Zhang, Yun; Grimster, Neil P.
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2023-11-176
OA
Boerth, Jeffrey A.; Chinn, Alex J.; Schimpl, Marianne; Bommakanti, Gayathri; Chan, Christina; Code, Erin L.; Giblin, Kathryn A.; Gohlke, Andrea; Hansel, Catherine S.; Jin, Meizhong; Kavanagh, Stefan L.; Lamb, Michelle L.; Lane, Jordan S.; Larner, Carrie J. B.; Mfuh, Adelphe M.; Moore, Rachel K.; Puri, Taranee; Quinn, Taylor R.; Ye, Minwei; Robbins, Kevin J.; Gancedo-Rodrigo, Miguel; Tang, Haoran; Walsh, Jarrod; Ware, Jamie; Wrigley, Gail L.; Reddy, Iswarya Karapa; Zhang, Yun; Grimster, Neil P.
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-09-223
PRE
Nilsson, Magnus; Berggren, Kristina; Berglund, Susanne; Cerboni, Silvia; Collins, Mia; Dahl, Goran; Elmqvist, David; Grimster, Neil P.; Hendrickx, Ramon; Johansson, Johan R.; Kettle, Jason G.; Lepisto, Matti; Rhedin, Magdalena; Smailagic, Amir; Su, Qibin; Wennberg, Tiiu; Wu, Allan; Osterlund, Torben; Naessens, Thomas; Mitra, Suman
Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor

发现 (2R)-N-[3-[2-[(3-甲氧基-1-甲基-吡唑-4-基) 氨基] pyrimidin-4-yl]-1h-吲哚-7-基]-2-(4-甲基哌嗪-1-基) 丙烯酰胺 (AZD4205) 作为有效和选择性的Janus激酶1抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-04-1639
PREAI
Su, Qibin; Banks, Erica; Bebernitz, Geraldine; Bell, Kirsten; Borenstein, Cassandra F.; Chen, Huawei; Chuaqui, Claudio E.; Deng, Nanhua; Ferguson, Andrew D.; Kawatkar, Sameer; Grimster, Neil P.; Ruston, Linette; Lyne, Paul D.; Read, Jon A.; Peng, Xianyou; Pei, Xiaohui; Fawell, Stephen; Tang, Zhanlei; Throner, Scott; Vasbinder, Melissa M.; Wang, Haoyu; Winter-Holt, Jon; Woessner, Richard; Wu, Allan; Yang, Wenzhan; Zinda, Michael; Kettle, Jason G.
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-06-0117
PREAI
Grimster, Neil P.; Anderson, Erica; Alimzhanov, Marat; Bebernitz, Geraldine; Bell, Kirsten; Chuaqui, Claudio; Deegan, Tracy; Ferguson, Andrew D.; Gero, Thomas; Harsch, Andreas; Huszar, Dennis; Kawatkar, Aarti; Kettle, Jason G.; Lyne, Paul; Read, Jon A.; Costa, Caroline Rivard; Ruston, Linette; Schroeder, Patricia; Shi, Jie; Su, Qibin; Throner, Scott; Toader, Dorin; Vasbinder, Melissa; Woessner, Richard; Wang, Haixia; Wu, Allan; Ye, Minwei; Zheng, Weijia; Zinda, Michael

研究方向

暂未获取到该数据
J
Jason G. Kettle
H 指数:31论文数:163被引数:3,394
Q
Qibin Su
H 指数:17论文数:38被引数:1,018
G
Gayathri Bommakanti
H 指数:9论文数:36被引数:542
M
Marianne Schimpl
H 指数:26论文数:86被引数:2,040
K
Kathryn A. Giblin
H 指数:10论文数:18被引数:383
R
Richard Woessner
H 指数:28论文数:147被引数:3,436
M
Minwei Ye
H 指数:16论文数:68被引数:1,461
J
Jeffery W. Kelly
H 指数:119论文数:617被引数:5.2万
N
Niresh Hariparsad
H 指数:20论文数:60被引数:1,370
V
Valery V. Fokin
H 指数:82论文数:345被引数:4.6万