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Y

Yu Chi Yang

revolution medicines
H指数:21
被引数:3,632

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Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer

对RAS(ON) 多选择性抑制剂daraxonrasib的获得性耐药性指导胰腺癌的合理联合治疗策略

Nature Medicine
IF50
2026-08-110
OA
Ida Aronchik; Sumit Kar; Yongxian Zhuang; Ethan Ahler; Lick Pui Lai; Vidya Seshadri; Yu Chi Yang; Ashenafi Bulle; Marie Menard; Biswadeep Nayak; Mark P. Labrecque; Julien Dilly; Eejung Kim; Lingyan Jiang; Jason Yano; Urszula N. Wasko; Ciara Helland; Sean Bredeson; Brett Garrick; Yevgeniy Gindin; Brad Sickler; Xing Wei; Kyle Seamon; Jingjing Jiang; Kian-Huat Lim; Matthew Holderfield; Elsa Quintana; Aparna Hegde; Zeena Salman; Alexander Starodub; Alexander Spira; Wungki Park; David S. Hong; Minal Barve; Meredith Pelster; David Sommerhalder; Salman R. Punekar; Ignacio Garrido-Laguna; Brian M. Wolpin; Anirban Maitra; W. Clay Gustafson; Steve Kelsey; Jacqueline A. M. Smith; Kevin K. Lin; Andrew J. Aguirre; Mallika Singh
Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers

靶向MYC癌基因的选择性双立体mTORC1抑制剂可诱导MYC驱动的癌症肿瘤消退

Cell Chemical Biology
IF7.2
2025-08-120
PRE
Wadie D. Mahauad-Fernandez; Yu Chi Yang; Ian Lai; Jangho Park; Lilian Yao; James W. Evans; Danielle F. Atibalentja; Xinyu Chen; Vishnupriya Kanakaveti; Zihui Zhao; G. Leslie Burnett; Bianca J. Lee; Nuntana Dinglasan; Nataliya Tovbis Shifrin; Ethan Ahler; Elsa Quintana; Adrian L. Gill; Jacqueline A.M. Smith; Mallika Singh; Dean W. Felsher
Combination RASG12C(ON) and RASMULTI(ON) inhibition overcomes resistance and prolongs durability in preclinical models of mutant KRASG12C-driven cancers

RASG12C(ON) 和RASMULTI(ON) 抑制的组合克服了耐药性并延长了突变KRASG12C-driven癌症临床前模型的持久性

CANCER RESEARCH
IF16.6
2024-03-220
PRE
Wei, Xing; Holderfield, Matthew; Yang, Yu Chi; Seamon, Kyle; Dinglasan, Jay; Montazar, Nilufar; Lee, Bianca; Cai, Shurui; Lai, Lick; Aronchik, Ida; Chang, Stephanie; Wang, Zhican; Wildes, Pete; Smith, Jacqueline A.; Jiang, Jingjing; Singh, Mallika
Bi-steric mTORC1-selective inhibitors activate 4EBP1, suppress MYC, restore anti-tumor immunity, and cooperate with immune checkpoint inhibition to elicit tumor regression
CANCER RESEARCH
IF16.6
2023-04-141
PRE
Mahauad-Fernandez, Wadie D.; Yang, Yu Chi; Lai, Ian; Park, Jangho; Yao, Lilian; Evans, James W.; Atibalentja, Danielle F.; Chen, Xinyu; Zhao, Zihui; Burnett, G. Leslie; Lee, Bianca J.; Dinglasan, Nuntana; Shifrin, Nataliya; Ahler, Ethan; Quintana, Elsa; Gill, Adrian; Smith, Jacqueline A.; Singh, Mallika; Felsher, Dean W.
RM-046, a first-in-class, mutant-selective, and oral KRASQ61H(ON) inhibitor that drives tumor regression in preclinical models and validates KRASQ61H as a therapeutic target
CANCER RESEARCH
IF16.6
2023-04-042
PRE
Yang, Yu C.; Thompson, Severin; Montgomery, David; Quinones, Antonio J.; Wei, Xing; Madej, Benjamin; Tomlinson, Aidan; Shifrin, Nataliya T.; McNamara, Alexander; Ahler, Ethan; McDowell, Laura L.; Flagella, Michael; Setser, John; Chang, Stephanie; Wang, Zhican; Wang, Zhengping; Huang, Jun; Ballmer, Steve; Li, Shaong; Buckl, Andreas; Koltun, Elena; Gill, Adrian; Jiang, Jingjing; Singh, Mallika; Smith, Jacqueline A.
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

细胞伴侣的化学重塑以靶向突变KRAS的活性状态

Science
IF45.8
2023-01-010
OA
Christopher J. Schulze; Kyle J. Seamon; Yulei Zhao; Yu Chi Yang; Jim Cregg; Dong-Sung Kim; Aidan C.A. Tomlinson; Tiffany J. Choy; Zhican Wang; Ben Sang; Yasin Pourfarjam; Jessica Lucas; Antonio Cuevas-Navarro; Carlos I. Ayala-Santos; Alberto Vides; Chuanchuan Li; Abby Marquez; Mengqi Zhong; Vidyasiri Vemulapalli; Caroline E. Weller; Andrea Gould; Daniel M. Whalen; Anthony Salvador; Anthony N. Milin; Mae Saldajeno-Concar; Nuntana Dinglasan; Anqi Chen; Jim Evans; John E. Knox; Elena S. Koltun; Mallika Singh; Robert J. Nichols; David P. Wildes; Adrian L. Gill; Jacqueline A.M. Smith; Piro Lito
Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors

mTORC1的选择性双空间抑制剂RMC-5552的发现，用于治疗mTORC1-Activated肿瘤

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-12-1922
OAAI
Burnett, G. Leslie; Yang, Yu C.; Aggen, James B.; Pitzen, Jennifer; Gliedt, Micah K.; Semko, Chris M.; Marquez, Abby; Evans, James W.; Wang, Gang; Won, Walter S.; Tomlinson, Aidan C. A.; Kiss, Gert; Tzitzilonis, Christos; Thottumkara, Arun P.; Cregg, James; Mellem, Kevin T.; Choi, Jong S.; Lee, Julie C.; Zhao, Yongyuan; Lee, Bianca J.; Meyerowitz, Justin G.; Knox, John E.; Jiang, Jingjing; Wang, Zhican; Wildes, David; Wang, Zhengping; Singh, Mallika; Smith, Jacqueline A. M.; Gill, Adrian L.
Defining cellular population dynamics at single-cell resolution during prostate cancer progression
ELIFE
IF0
2022-12-138
OA
Germanos, Alexandre A.; Arora, Sonali; Zheng, Ye; Goddard, Erica T.; Coleman, Ilsa M.; Ku, Anson T.; Wilkinson, Scott; Song, Hanbing; Brady, Nicholas J.; Amezquita, Robert A.; Zager, Michael; Long, Annalysa; Yang, Yu Chi; Bielas, Jason H.; Gottardo, Raphael; Rickman, David S.; Huang, Franklin W.; Ghajar, Cyrus M.; Nelson, Peter S.; Sowalsky, Adam G.; Setty, Manu; Hsieh, Andrew C.
Chinese Expert Consensus on Immunotherapy for Hepatocellular Carcinoma (2021 Edition)

肝细胞癌免疫治疗中国专家共识 (2021版)

LIVER CANCER
IF9.1
2022-07-2013
OAAI
Yang, Yu; Sun, Juxian; Wu, Mengchao; Lau, Wan Yee; Zheng, Shusen; Wang, Xue-Hao; Chen, Xiaoping; Fan, Jia; Dong, Jiahong; Cai, Jianqiang; Chen, Minshan; Chen, Yongjun; Cheng, Zhangjun; Dai, Chaoliu; Shan, Jianzhen; Du, Cheng-You; Fang, Chihua; Hu, Heping; Ji, Zhili; Jia, Weidong; Li, Gong; Li, Jing; Li, Jiangtao; Liu, Chang; Liu, Fubao; Ma, Yong; Mao, Yilei; Niu, Zuoxing; Shen, Jie; Shi, Jie; Shi, Xuetao; Song, Wenjie; Sun, Hui-Chuan; Tan, Guang; Tao, Ran; Wang, Xiaohu; Wen, Tianfu; Wu, Liqun; Xia, Jinglin; Xiang, Bang-De; Yan, Maolin; Ying, Mingang; Zhang, Ling; Zhang, Xuewen; Zeng, Zhao Chong; Zhang, Yubao; Zhang, Zhiwei; Zhou, Jie; Zhou, Cuncai; Zhou, Jun; Zhou, Ledu; Zhou, Xinmin; Zhu, Ji; Zhu, Zhenyu; Zhang, Qi; Li, Qiu; Cheng, Shuqun
SHP2 inhibition as the backbone of targeted therapy combinations for the treatment of cancers driven by oncogenic mutations in the RAS pathway
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Smith, Jacqueline A.; Singh, Mallika; Nichols, Robert J.; Koltun, Elena S.; Yang, Yu C.; Wildes, David P.; Stahlhut, Carlos; Lee, Dong; Schulze, Chris J.; Reyes, Denise; Marquez, Abby; Lee, Grace J.; Li, Shaoling; Marcireau, Christophe; Debussche, Laurent; Goldsmith, Mark A.; Wang, Zhengping; Gill, Adrian L.; Kelsey, Steve M.
Tri-complex inhibitors of the oncogenic, GTP-bound form of KRASG12c overcome RTK-mediated escape mechanisms and drive tumor regressions in vivo
MOLECULAR CANCER THERAPEUTICS
IF5.5
2019-12-0118
PRE
Schulze, Christopher J.; Bermingham, Alun; Choy, Tiffany J.; Cregg, James J.; Kiss, Gert; Marquez, Abby; Reyes, Denise; Saldajeno-Concar, Mae; Weller, Caroline E.; Whalen, Daniel M.; Yang, Yu C.; Koltun, Elena S.; Nichols, Robert J.; Singh, Mallika; Wildes, David; Gill, Adrian L.; Hansen, Richard L.; Kelsey, Steve; Goldsmith, Mark A.; Smith, Jacqueline A. M.
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2019-09-16260
OA
Labrecque, Mark P.; Coleman, Ilsa M.; Brown, Lisha G.; True, Lawrence D.; Kollath, Lori; Lakely, Bryce; Nguyen, Holly M.; Yang, Yu C.; da Costa, Rui M. Gil; Kaipainen, Arja; Coleman, Roger; Higano, Celestia S.; Yu, Evan Y.; Cheng, Heather H.; Mostaghel, Elahe A.; Montgomery, Bruce; Schweizer, Michael T.; Hsieh, Andrew C.; Lin, Daniel W.; Corey, Eva; Nelson, Peter S.; Morrissey, Colm

研究方向

暂未获取到该数据
M
Mallika Singh
H 指数:42论文数:315被引数:8,601
J
Jacqueline A.M. Smith
H 指数:33论文数:225被引数:4,342
M
Marianne D. Sadar
H 指数:43论文数:200被引数:6,838
A
Adrian L. Gill
H 指数:28论文数:154被引数:3,081
N
Nasrin R. Mawji
H 指数:18论文数:96被引数:2,218
P
Peter S. Nelson
H 指数:113论文数:1,484被引数:6.6万
I
Ilsa M. Coleman
H 指数:62论文数:641被引数:1.7万
Z
Zhican Wang
H 指数:25论文数:125被引数:2,242
D
David Wildes
H 指数:19论文数:125被引数:2,163
Z
Zhengping Wang
H 指数:31论文数:254被引数:3,653