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CCN2 Activates Cellular Senescence Leading to Kidney Fibrosis in Folic Acid-Induced Experimental Nephropathy CCN2激活细胞衰老，导致叶酸诱导的实验性肾病中的肾脏纤维化 Tejedor-Santamaria, Lucia; Marquez-Exposito, Laura; Villacampa, Alicia; Marchant, Vanessa; Battaglia-Vieni, Antonio; Rayego-Mateos, Sandra; Rodrigues-Diez, Raul R.; Santos, Fatima Milhano; Valentijn, Floris A.; Knoppert, Sebastian N.; Broekhuizen, Roel; Ruiz-Torres, Maria Piedad; Goldschmeding, Roel; Ortiz, Alberto; Peiro, Concepcion; Nguyen, Tri Q.; Ramos, Adrian M.; Ruiz-Ortega, Marta 分享 收藏
Aging-related hyperphosphatemia triggers the release of TNF-α from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle 衰老相关的高磷血症触发巨噬细胞释放tnf-α，通过减少骨骼肌中IL-15的表达促进肌肉减少的指标 Alcalde-Estevez, Elena; Moreno-Piedra, Ariadna; Asenjo-Bueno, Ana; Martos-Elvira, Maria; de la Serna-soto, Mariano; Ruiz-Ortega, Marta; Olmos, Gemma; Lopez-Ongil, Susana; Ruiz-Torres, Maria P. 分享 收藏
Aging-related hyperphosphatemia triggers the release of TNF-α from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle (vol 368, 123507, 2025) 年龄相关的血磷过高会触发巨噬细胞释放TNF-α，通过减少骨骼肌中IL-15的表达来促进肌少症的指标（卷368，123507，2025）。 Alcalde-Estevez, Elena; Moreno-Piedra, Ariadna; Asenjo-Bueno, Ana; Martos-Elvira, Maria; de la Serna-soto, Mariano; Ruiz-Ortega, Marta; Olmos, Gemma; Lopez-Ongil, Susana; Ruiz-Torres, Maria P. 分享 收藏
Integrin-Linked Kinase (ILK) Promotes Mitochondrial Dysfunction by Decreasing CPT1A Expression in a Folic Acid-Based Model of Kidney Disease 整合素连接激酶（Integrin-Linked Kinase, ILK）通过降低CPT1A表达促进线粒体功能障碍，在一个基于叶酸的肾脏疾病模型中。 de la Serna-soto, Mariano; Calleros, Laura; Martos-Elvira, Maria; Moreno-Piedra, Ariadna; Garcia-Villoria, Sergio; Griera, Mercedes; Alcalde-Estevez, Elena; Asenjo-Bueno, Ana; Rodriguez-Puyol, Diego; de Frutos, Sergio; Ruiz-Torres, Maria Piedad 分享 收藏
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Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure Martinez-Arias, Laura; Fernandez-Villabrille, Sara; Alonso-Montes, Cristina; Garcia-Navazo, Gonzalo; Ruiz-Torres, Maria P.; Alajarin, Ramon; Alvarez-Builla, Julio; Gutierrez-Calabres, Elena; Vaquero-Lopez, Juan Jose; Carrillo-Lopez, Natalia; Rodriguez-Puyol, Diego; Cannata-Andia, Jorge B.; Panizo, Sara; Naves-Diaz, Manuel 分享 收藏
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Vitamin D Treatment Prevents Uremia-Induced Reductions in Aortic microRNA-145 Attenuating Osteogenic Differentiation despite Hyperphosphatemia Carrillo-Lopez, Natalia; Panizo, Sara; Vittoria Arcidiacono, Maria; de la Fuente, Sandra; Martinez-Arias, Laura; Ottaviano, Emerenziana; Ulloa, Catalina; Piedad Ruiz-Torres, Maria; Rodriguez, Isabel; Cannata-Andia, Jorge B.; Naves-Diaz, Manuel; Dusso, Adriana S. 分享 收藏
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Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis Alcalde-Estevez, Elena; Sosa, Patricia; Asenjo-Bueno, Ana; Plaza, Patricia; Olmos, Gemma; Naves-Diaz, Manuel; Rodriguez-Puyol, Diego; Lopez-Ongil, Susana; Ruiz-Torres, Maria P. 分享 收藏
Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia Sosa, Patricia; Alcalde-Estevez, Elena; Plaza, Patricia; Troyano, Nuria; Alonso, Cristina; Martinez-Arias, Laura; de Melo Aroeira, Andresa Evelem; Rodriguez-Puyol, Diego; Olmos, Gemma; Lopez-Ongil, Susana; Ruiz-Torres, Maria P. 分享 收藏
Complement activation: the missing link between ADAMTS-13 deficiency and microvascular thrombosis of thrombotic microangiopathies Ruiz-Torres, MP; Casiraghi, F; Galbusera, M; Macconi, D; Gastoldi, S; Todeschini, M; Porrati, F; Belotti, D; Pogliani, EM; Noris, M; Remuzzi, G 分享 收藏
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Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production 高磷血症通过增加endothelin-1产生诱导人内皮细胞衰老 Olmos, Gemma; Martinez-Miguel, Patricia; Alcalde-Estevez, Elena; Medrano, Diana; Sosa, Patricia; Rodriguez-Manas, Leocadio; Naves-Diaz, Manuel; Rodriguez-Puyol, Diego; Piedad Ruiz-Torres, Maria; Lopez-Ongil, Susana 分享 收藏
Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification Alique, Matilde; Piedad Ruiz-Torres, Maria; Bodega, Guillermo; Victoria Noci, Maria; Troyano, Nuria; Bohorquez, Lourdes; Luna, Carlos; Luque, Rafael; Carmona, Andres; Carracedo, Julia; Ramirez, Rafael 分享 收藏
Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load Quiros-Gonzalez, Isabel; Roman-Garcia, Pablo; Alonso-Montes, Cristina; Barrio-Vazquez, Sara; Carrillo-Lopez, Natalia; Naves-Diaz, Manuel; Isabel Mora, Maria; Jose Corrales, Fernando; Lopez-Hernandez, Francisco J.; Piedad Ruiz-Torres, Maria; Benito Cannata-Andia, Jorge; Luis Fernandez-Martin, Jose 分享 收藏
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