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M

Madeline G. Dans

the walter and eliza hall institute of medical research
H指数:12
被引数:452

个人简介

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2-Amino-3; 4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X

2-氨基-3,4-二氢喹唑啉类化合物通过靶向血红素X展示显著的抗疟疾活性

ACS Infectious Diseases
IF3.8
2026-08-140
PRE
Madeline G. Dans; Jon Kyle Awalt; Nghi Nguyen; Josephine Palandri; Anna Ngo; Kate E. Jarman; Jin H. Jeon; Tomas Yeo; Heekuk Park; Anne-Catrin Uhlemann; Emma Y. Mao; Maria R. Gancheva; Danny W. Wilson; Partha Mukherjee; Arnish Chakraborty; Mojca Kristan; Lindsay Stewart; Colin J. Sutherland; Delphine Baud; Stephen Brand; David A. Fidock; Paul F. Jackson; Alan F. Cowman; Brad E. Sleebs
Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter

针对由ABCI3转运蛋白介导耐药性的嘧啶-2,4-二胺类化合物的抗疟活性探索与表征

CHEMMEDCHEM
IF3.4
2025-12-010
OAAI
Mansouri, Mahta; Dans, Madeline G.; Low, Zijun; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Lehane, Adele M.; Crespo, Benigno; Gamo, Franciso-javier; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in Plasmodium falciparum Parasites

在恶性疟原虫中解卷积靶向活性的质膜素V类肽模拟物

ACS INFECTIOUS DISEASES
IF3.8
2025-12-010
PRE
Su, Wenyin; Nguyen, William; Siddiqui, Ghizal; Dziekan, Jerzy M.; Marapana, Danushka; Penington, Jocelyn Sietsma; Mehra, Somya; Razook, Zahra; McCann, Kirsty; Ngo, Anna; Jarman, Kate E.; Barry, Alyssa E.; Papenfuss, Anthony T.; Gilson, Paul R.; Creek, Darren John; Cowman, Alan F.; Sleebs, Brad E.; Dans, Madeline G.
Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

ROM8和CSC1易受突变影响的N-芳基乙酰胺类化合物的抗疟活性的优化与表征

Journal of Medicinal Chemistry
IF6.8
2025-07-180
OA
William Nguyen; Coralie Boulet; Madeline G. Dans; Katie Loi; Kate E. Jarman; Claudia B. G. Barnes; Tomas Yeo; Tanaya Sheth; Partha Mukherjee; Arnish Chakraborty; Mufuliat T. Famodimu; Michael J. Delves; Harry Pollard; Colin J. Sutherland; Rachael Coyle; Nicole Sevilleno; Nonlawat Boonyalai; Marcus C. S. Lee; Tayla Rabie; Lyn-Marié Birkholtz; Delphine Baud; Stephen Brand; Mrittika Chowdury; Tania F. de Koning-Ward; David A. Fidock; Paul R. Gilson; Brad E. Sleebs
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

N-乙酰胺基吲哚类化合物的优化与表征：靶向PfATP4的抗疟疾药物研究

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-04-140
PRE
Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D.; Mansouri, Mahta; Calic, Petar P. S.; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Giannangelo, Carlo; MacRaild, Christopher A.; Creek, Darren J.; Yeo, Tomas; Sheth, Tanaya; Fidock, David A.; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T.; Delves, Michael J.; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J.; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C. S.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

针对线粒体蛋白，细胞色素b的环丙基甲酰胺的抗疟活性的探索和表征

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
OAAI
Awalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Ramesh, Saishyam; Fairhurst, Kate J.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Maity, Bikash Chandra; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T.; Delves, Michael J.; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A.; Papenfuss, Anthony T.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Maier, Alexander G.; van Dooren, Giel G.; Baud, Delphine; Brand, Stephen; Fidock, David A.; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

内酰胺截短产生具有针对PfATP4的有效抗疟活性的二氢喹唑啉酮支架

CHEMMEDCHEM
IF3.4
2024-10-291
PRE
Ashton, Trent D.; Calic, Petar P. S.; Dans, Madeline G.; Ooi, Zi Kang; Zhou, Qingmiao; Loi, Katie; Jarman, Kate E.; Palandri, Josephine; Qiu, Deyun; Lehane, Adele M.; Maity, Bikash; De, Nirupam; Famodimu, Mufuliat T.; Delves, Michael J.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 (vol 15, 5219, 2024)

芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1 (vol 15，5219，2024) 防止恶性疟原虫环发育

NATURE COMMUNICATIONS
IF15.7
2024-09-300
OAAI
Dans, Madeline G.; Boulet, Coralie; Watson, Gabrielle M.; Nguyen, William; Dziekan, Jerzy M.; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Mlodzianoski, Michael J.; Goodman, Christopher Dean; Ling, Dawson B.; Jonsdottir, Thorey K.; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B.; Brandner-Garrod, Luke; Sutherland, Colin J.; Delves, Michael J.; Mcfadden, Geoffrey I.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Rogers, Kelly L.; Cowman, Alan F.; Tham, Wai-Hong; Sleebs, Brad E.; Gilson, Paul R.
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Dihydroquinazolinone-3-carboxamides作为靶向PfATP4的口服有效抗疟药的性质和活性精制

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-122
OAAI
Ashton, Trent D.; Calic, Petar P. S.; Dans, Madeline G.; Ooi, Zi Kang; Zhou, Qingmiao; Palandri, Josephine; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Maity, Bikash Chandra; De, Nirupam; Giannangelo, Carlo; Macraild, Christopher A.; Creek, Darren J.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Famodimu, Mufuliat T.; Delves, Michael J.; Pollard, Harry; Sutherland, Colin J.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1

芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1阻止恶性疟原虫环的发展

NATURE COMMUNICATIONS
IF15.7
2024-06-185
OAAI
Dans, Madeline G.; Boulet, Coralie; Watson, Gabrielle M.; Nguyen, William; Dziekan, Jerzy M.; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Mlodzianoski, Michael J.; Goodman, Christopher Dean; Ling, Dawson B.; Jonsdottir, Thorey K.; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B.; Brandner-Garrod, Luke; Sutherland, Colin J.; Delves, Michael J.; Mcfadden, Geoffrey I.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Rogers, Kelly L.; Cowman, Alan F.; Tham, Wai-Hong; Sleebs, Brad E.; Gilson, Paul R.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
MBIO
IF4.7
2024-06-120
OAAI
Edgar, Rebecca C. S.; Malcolm, Tess R.; Siddiqui, Ghizal; Giannangelo, Carlo; Counihan, Natalie A.; Challis, Matthew; Duffy, Sandra; Chowdhury, Mrittika; Marfurt, Jutta; Dans, Madeline; Wirjanata, Grennady; Noviyanti, Rintis; Daware, Kajal; Suraweera, Chathura D.; Price, Ric N.; Wittlin, Sergio; Avery, Vicky M.; Drinkwater, Nyssa; Charman, Susan A.; Creek, Darren J.; de Koning-Ward, Tania F.; Scammells, Peter J.; McGowan, Sheena
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein

靶向恶性疟原虫星形相关脂质转移1蛋白的芳基氨基乙酰胺的活性精制

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-04-014
OAAI
Nguyen, William; Boulet, Coralie; Dans, Madeline G.; Loi, Katie; Jarman, Kate E.; Watson, Gabrielle M.; Tham, Wai-Hong; Fairhurst, Kate J.; Yeo, Tomas; Fidock, David A.; Wittlin, Sergio; Chowdury, Mrittika; de Koning-Ward, Tania F.; Chen, Gong; Yan, Dandan; Charman, Susan A.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Gilson, Paul R.; Sleebs, Brad E.
7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex

具有有效抗疟活性的7-n取代的3-恶二唑喹诺酮类药物靶向细胞色素bc1复合物

ACS INFECTIOUS DISEASES
IF3.8
2023-02-2810
OAAI
Nguyen, William; Dans, Madeline G.; Currie, Iain; Awalt, Jon Kyle; Bailey, Brodie L.; Lumb, Chris; Ngo, Anna; Favuzza, Paola; Palandri, Josephine; Ramesh, Saishyam; Penington, Jocelyn; Jarman, Kate E.; Mukherjee, Partha; Chakraborty, Arnish; Maier, Alexander G.; van Dooren, Giel G.; Papenfuss, Tony; Wittlin, Sergio; Churchyard, Alisje; Baum, Jake; Winzeler, Elizabeth A.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

靶向PfATP4的2，3-二氢喹唑啉酮-3-甲酰胺类抗疟药的优化

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-02-229
OAAI
Ashton, Trent D.; Dans, Madeline G.; Favuzza, Paola; Ngo, Anna; Lehane, Adele M.; Zhang, Xinxin; Qiu, Deyun; Maity, Bikash Chandra; De, Nirupam; Schindler, Kyra A.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Churchyard, Alisje; Baum, Jake; Fidock, David A.; Jarman, Kate E.; Lowes, Kym N.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.

研究方向

暂未获取到该数据
B
Brad E. Sleebs
H 指数:30论文数:159被引数:3,999
A
Alan F. Cowman
H 指数:113论文数:463被引数:4.1万
T
Tania F. de Koning‐Ward
H 指数:41论文数:150被引数:6,453
P
Paul R. Gilson
H 指数:57论文数:191被引数:1.1万
K
Kate E. Jarman
H 指数:20论文数:68被引数:1,560
D
Delphine Baud
H 指数:9论文数:29被引数:288
S
Stephen Brand
H 指数:26论文数:70被引数:2,218
P
Paul Jackson
H 指数:26论文数:147被引数:2,576
W
William Nguyen
H 指数:25论文数:105被引数:6,837
M
Mufuliat T. Famodimu
H 指数:8论文数:25被引数:294