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T

Tania F. de Koning-Ward

Deakin University
H指数:41
被引数:6,453

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Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

ROM8和CSC1易受突变影响的N-芳基乙酰胺类化合物的抗疟活性的优化与表征

Journal of Medicinal Chemistry
IF6.8
2025-07-180
OA
William Nguyen; Coralie Boulet; Madeline G. Dans; Katie Loi; Kate E. Jarman; Claudia B. G. Barnes; Tomas Yeo; Tanaya Sheth; Partha Mukherjee; Arnish Chakraborty; Mufuliat T. Famodimu; Michael J. Delves; Harry Pollard; Colin J. Sutherland; Rachael Coyle; Nicole Sevilleno; Nonlawat Boonyalai; Marcus C. S. Lee; Tayla Rabie; Lyn-Marié Birkholtz; Delphine Baud; Stephen Brand; Mrittika Chowdury; Tania F. de Koning-Ward; David A. Fidock; Paul R. Gilson; Brad E. Sleebs
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4

N-乙酰胺基吲哚类化合物的优化与表征：靶向PfATP4的抗疟疾药物研究

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-04-140
PRE
Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D.; Mansouri, Mahta; Calic, Petar P. S.; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Giannangelo, Carlo; MacRaild, Christopher A.; Creek, Darren J.; Yeo, Tomas; Sheth, Tanaya; Fidock, David A.; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T.; Delves, Michael J.; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J.; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C. S.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
PfGCN5 is essential for Plasmodium falciparum survival and transmission and regulates Pf H2B.Z acetylation and chromatin structure

PfGCN5对于 *Plasmodium falciparum* 的生存和传播至关重要，并调控 Pf H2B.Z 的乙酰化和染色质结构。

NUCLEIC ACIDS RESEARCH
IF13.1
2025-03-290
OA
Tang, Jingyi; Yeoh, Lee M.; Grotz, Myriam D.; Goodman, Christopher D.; Chisholm, Scott A.; Nguyen, Hanh H. T.; Yu, Chunhao; Pareek, Kapil; Mcpherson, Fairley; Cozijnsen, Anton; Hustadt, Samuel A.; Josling, Gabrielle A.; Day, Karen P.; Schulz, Danae; Mcfadden, Geoffrey, I; de Koning-Ward, Tania F.; Petter, Michaela; Duffy, Michael F.
Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

针对线粒体蛋白，细胞色素b的环丙基甲酰胺的抗疟活性的探索和表征

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-12-010
OAAI
Awalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Ramesh, Saishyam; Fairhurst, Kate J.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Maity, Bikash Chandra; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T.; Delves, Michael J.; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A.; Papenfuss, Anthony T.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Maier, Alexander G.; van Dooren, Giel G.; Baud, Delphine; Brand, Stephen; Fidock, David A.; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

内酰胺截短产生具有针对PfATP4的有效抗疟活性的二氢喹唑啉酮支架

CHEMMEDCHEM
IF3.4
2024-10-291
PRE
Ashton, Trent D.; Calic, Petar P. S.; Dans, Madeline G.; Ooi, Zi Kang; Zhou, Qingmiao; Loi, Katie; Jarman, Kate E.; Palandri, Josephine; Qiu, Deyun; Lehane, Adele M.; Maity, Bikash; De, Nirupam; Famodimu, Mufuliat T.; Delves, Michael J.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3

具有有效抗疟活性的吡唑并吡啶4-甲酰胺的优化，其抗性与恶性疟原虫转运蛋白ABCI3相关

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-10-013
OAAI
Calic, Petar P. S.; Ashton, Trent D.; Mansouri, Mahta; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Roy, Sayantan; Rao, Gunturu P.; Maity, Bikash; Wittlin, Sergio; Crespo, Benigno; Gamo, Franciso-Javier; Deni, Ioanna; Fidock, David A.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Cowman, Alan F.; Jackson, Paul F.; Baud, Delphine; Brand, Stephen; Laleu, Benoit; Sleebs, Brad E.
Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 (vol 15, 5219, 2024)

芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1 (vol 15，5219，2024) 防止恶性疟原虫环发育

NATURE COMMUNICATIONS
IF15.7
2024-09-300
OAAI
Dans, Madeline G.; Boulet, Coralie; Watson, Gabrielle M.; Nguyen, William; Dziekan, Jerzy M.; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Mlodzianoski, Michael J.; Goodman, Christopher Dean; Ling, Dawson B.; Jonsdottir, Thorey K.; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B.; Brandner-Garrod, Luke; Sutherland, Colin J.; Delves, Michael J.; Mcfadden, Geoffrey I.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Rogers, Kelly L.; Cowman, Alan F.; Tham, Wai-Hong; Sleebs, Brad E.; Gilson, Paul R.
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Dihydroquinazolinone-3-carboxamides作为靶向PfATP4的口服有效抗疟药的性质和活性精制

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-08-122
OAAI
Ashton, Trent D.; Calic, Petar P. S.; Dans, Madeline G.; Ooi, Zi Kang; Zhou, Qingmiao; Palandri, Josephine; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Maity, Bikash Chandra; De, Nirupam; Giannangelo, Carlo; Macraild, Christopher A.; Creek, Darren J.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Famodimu, Mufuliat T.; Delves, Michael J.; Pollard, Harry; Sutherland, Colin J.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1

芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1阻止恶性疟原虫环的发展

NATURE COMMUNICATIONS
IF15.7
2024-06-185
OAAI
Dans, Madeline G.; Boulet, Coralie; Watson, Gabrielle M.; Nguyen, William; Dziekan, Jerzy M.; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Mlodzianoski, Michael J.; Goodman, Christopher Dean; Ling, Dawson B.; Jonsdottir, Thorey K.; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B.; Brandner-Garrod, Luke; Sutherland, Colin J.; Delves, Michael J.; Mcfadden, Geoffrey I.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Rogers, Kelly L.; Cowman, Alan F.; Tham, Wai-Hong; Sleebs, Brad E.; Gilson, Paul R.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
MBIO
IF4.7
2024-06-120
OAAI
Edgar, Rebecca C. S.; Malcolm, Tess R.; Siddiqui, Ghizal; Giannangelo, Carlo; Counihan, Natalie A.; Challis, Matthew; Duffy, Sandra; Chowdhury, Mrittika; Marfurt, Jutta; Dans, Madeline; Wirjanata, Grennady; Noviyanti, Rintis; Daware, Kajal; Suraweera, Chathura D.; Price, Ric N.; Wittlin, Sergio; Avery, Vicky M.; Drinkwater, Nyssa; Charman, Susan A.; Creek, Darren J.; de Koning-Ward, Tania F.; Scammells, Peter J.; McGowan, Sheena
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein

靶向恶性疟原虫星形相关脂质转移1蛋白的芳基氨基乙酰胺的活性精制

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-04-014
OAAI
Nguyen, William; Boulet, Coralie; Dans, Madeline G.; Loi, Katie; Jarman, Kate E.; Watson, Gabrielle M.; Tham, Wai-Hong; Fairhurst, Kate J.; Yeo, Tomas; Fidock, David A.; Wittlin, Sergio; Chowdury, Mrittika; de Koning-Ward, Tania F.; Chen, Gong; Yan, Dandan; Charman, Susan A.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Gilson, Paul R.; Sleebs, Brad E.

研究方向

暂未获取到该数据
P
Paul R. Gilson
H 指数:57论文数:191被引数:1.1万
B
Brendan S. Crabb
H 指数:71论文数:266被引数:1.7万
M
Madeline G. Dans
H 指数:12论文数:43被引数:452
B
Brad E. Sleebs
H 指数:30论文数:159被引数:3,999
A
Alan F. Cowman
H 指数:113论文数:463被引数:4.1万
M
Mrittika Chowdury
H 指数:5论文数:23被引数:108
N
Natalie A. Counihan
H 指数:13论文数:35被引数:1,051
S
Stephen Brand
H 指数:26论文数:70被引数:2,218
M
Mufuliat T. Famodimu
H 指数:8论文数:25被引数:294
M
Michael J. Delves
H 指数:37论文数:104被引数:5,549