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杜

杜冠华 (Guanhua Du)

chinese academy of medical sciences - peking union medical college

80H指数
1.1K论文数
2.9W被引数
收录论文 414
发表时间
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Black tea extract ameliorates fatty liver and fatty kidney in HFD-induced obese miceMa, P, Zhang, L, Wang, Z, Xu, T, Yang, H, Hou, B, et al. 黑茶提取物改善高脂饮食诱导的肥胖小鼠的脂肪肝和脂肪肾。Food Sci Human Wellness. (2024). doi: 10.26599/FSHW.2024.9250391
errFood Science and Human Wellness
IF7.4
err2026-03-01
err2
PREAI
errMa, Peng; Zhang, Li; Wang, Zijing; Xu, Tianshu; Yang, Haiguang; Hou, Biyu; Li, Yiwei; He, Ping; Lam, Sin Man; Shui, Guanghou; Li, Xiangyan; Du, Guanhua; Ying, Jian; Qiang, Guifen
err分享
err收藏
Arctium lappa L. Leaves Alleviate Alzheimer’s Disease-Like Pathologies by Modulating the Tricarboxylic Acid Cycle and Inhibiting STAT3/NF-кB Signaling牛蒡叶可通过调控三羧酸循环和抑制STAT3/NF-кB信号通路来减轻阿尔茨海默病样病理。
errPlant Foods for Human Nutrition
IF3.6
err2025-12-19
err0
PREAI
errRuixue Zhang; Shouchen Mu; Shimeng Zhang; Xuemei Qin; Guanhua Du; Yuzhi Zhou
err分享
err收藏
Natural triterpenoid assembly-driven co-delivery of betulinic acid and CDK4/6 inhibitors for amplified immunogenic cell death toward cancer immunotherapy天然三萜组装驱动的熊果酸与CDK4/6抑制剂协同递送，用于增强免疫原性细胞死亡以促进癌症免疫治疗
errChemical Engineering Journal
IF13.2
err2025-12-03
err0
PREAI
errYajie Lian; Conglei Zhou; Jianan Qi; Jianjun Cheng; Jiahua Shi; Guanhua Du
err分享
err收藏
Jiangtang Tiaozhi Formula alleviates obesity by enhancing adipose thermogenesis via TGR5-mediated gut-liver-adipose axis江唐调脂方通过TGR5介导的肠道-肝脏-脂肪轴增强脂肪产热来缓解肥胖。
errPhytomedicine
IF8.3
err2025-11-25
err0
PREAI
errLejia Hu; Zepeng Zhang; Tianshu Xu; Peng Ma; Zijing Wang; Li Zhang; Jiayi Chen; Ping He; Xiuying Yang; Guanhua Du; Fengmei Lian; Xiangyan Li; Guifen Qiang
err分享
err收藏
X-Ray Structures, Intermolecular Interactions, and Structural Transformations of Dihydroquercetin Solvates and PolymorphsX射线结构、分子间相互作用以及二氢槲皮素溶剂合物和同质多形体（多晶型物）的结构转变
errPharmaceutics 2025, Vol. 17, Page 1512
IF5.5
err2025-11-23
err0
errOAAI
errXin Meng; Yao Zou; Shiying Yang; Cheng Xing; Ningbo Gong; Guanhua Du; Yang Lu
err分享
err收藏
Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment晶体工程优化大黄素-四甲基吡嗪组合：从共晶设计到体内抗结肠炎功效评估
errInternational Journal of Pharmaceutics: X
IF0
err2025-11-05
err0
errOAAI
errMeiru Liu; Yinru Jiang; Penghui Yuan; Shuang Li; Baoxi Zhang; Xia Zhou; Bin Su; Yifei Xie; Dezhi Yang; Linglei Kong; Li Zhang; Yang Lv; Guanhua Du
err分享
err收藏
Ejiao alleviates sarcopenia by AKT/mTOR/Foxo3a and AMPK pathways in an aging rat model induced by D-Galactose combined with restricted movement阿胶通过AKT/mTOR/Foxo3a和AMPK通路缓解由D-半乳糖联合限制运动诱导的衰老大鼠模型中的肌肉减少症。
errJournal of Ethnopharmacology
IF5.4
err2025-10-28
err0
errOAAI
errHongwei Zhang; Shan Liu; Qin Feng; Haibin Liu; Juan Wu; Xiaobo Duan; Zhengjuan Li; Yue Zhang; Xiaoying Zhou; Mingchao Yv; Chuyi Liu; Jie Cheng; Guanhua Du; Lili Zhao
err分享
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Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke靶向中性粒细胞与小胶质细胞之间的相互作用：一种抗炎治疗中风的新策略
errActa Pharmacologica Sinica
IF8.4
err2025-10-01
err0
PREAI
errLong-rui Wang; Zi-yuan Zhao; Zhao-wei Li; Yin-ru Jiang; Wen-jing Sun; Guan-hua Du; Rui-li Shi; Ling-lei Kong
err分享
err收藏
Rare TRAF5 coding variants in systemic lupus erythematosus patients aggravate pulmonary hypertension via endothelial dysfunction系统性红斑狼疮患者中罕见的TRAF5编码变异通过内皮功能障碍加重肺动脉高压
errinnovation
IF0
err2025-09-04
err0
errOAAI
errXiaoyue Deng; Tianyi Yuan; Junyan Qian; Qian Wang; Ran-ran Wang; Xinzhuang Yang; Leyao Ma; Mucong Li; Guanhua Du; Mengtao Li; Xiaofeng Zeng; Lianhua Fang; Jiuliang Zhao
err分享
err收藏
Identification of novel SIRT1 up-regulators using a cell-based high-throughput screening assay使用基于细胞的高通量筛选方法鉴定新型的SIRT1上调调节剂
errEuropean Journal of Pharmacology
IF4.7
err2025-08-14
err0
PREAI
errYanjia Shen; Huilin Yang; Peng Gao; Wendan Lu; Qizhi Cao; Haiguang Yang; Guanhua Du; Li Li
err分享
err收藏
Hygroscopicity Reduction and Interconversion of Ligustrazine in Ligusticum chuanxiong Hort. via Cocrystallization and Mechanochemical Technology通过共晶化和机械化学技术实现川芎中川芎嗪的吸湿性降低与互变研究
errCrystal Growth & Design
IF0
err2025-08-12
err0
PREAI
errYifei Xie; Yue Tao; Zhenjiang Zhang; Jian Zhou; Kun Hu; Li Zhang; Shiying Yang; Dezhi Yang; Guanhua Du; Yang Lu
err分享
err收藏
Inhibition of UBE2C Promotes Parkin-Mediated K63-Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer抑制UBE2C促进Parkin介导的TOP2A K63连接的泛素化，以诱导衰老并增加乳腺癌对多柔比星敏感性
errAdvanced Science
IF14.1
err2025-07-29
err0
errOAAI
errYihui Yang; Wan Li; Hong Yang; Fang Xu; Sen Zhang; Wanxin Cao; Xiaoxue Li; Xu Zhang; Xiangyin Chi; Hongquan Wang; Guanhua Du; Yumin Wang; Jinhua Wang
err分享
err收藏
Exogenous ATP-induced lipolysis and its correlation with skeletal muscle atrophy and hepatic damage in fasting mice外源性ATP诱导的脂肪分解及其与禁食小鼠骨骼肌萎缩和肝损伤的相关性
errEuropean Journal of Pharmacology
IF4.7
err2025-07-21
err0
PREAI
errLiu Zhaoyu; Shang Jiamin; Ye Xiaomeng; Yin Zijie; Yang Zeyu; Yang Huilin; Du Guanhua; Yang Xiuying
err分享
err收藏
IFI30 promotes tumor-associated macrophage infiltration via activation of the ATF3-CCL5 axis in breast cancerIFI30通过激活ATF3-CCL5轴促进乳腺癌中肿瘤相关巨噬细胞的浸润
errThe Innovation
IF0
err2025-06-21
err0
errOAAI
errLiwen Ren; Yihui Yang; Wan Li; Xiangjin Zheng; Jinyi Liu; Sha Li; Hong Yang; Yizhi Zhang; Hongquan Wang; Guanhua Du; Xifu Wang; Jinhua Wang
err分享
err收藏
Design, synthesis and biological activity of novel pyrimidine piperazine ureas as μ-opioid and TRPV1 dual-target ligands for pain management新型嘧啶哌嗪脲类化合物的设计、合成及其作为μ-阿片和TRPV1双靶点配体在疼痛管理中的生物活性
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-05-10
err0
PREAI
errWang, Yusui; Liu, Shuyu; Zhang, Zhikang; Ma, Yunmeng; Qin, Kexin; Du, Jiahao; Wang, Yu; Wang, Bingxin; Qian, Hai; Pang, Xiaobin; Zhao, Fenqin; Du, Guanhua; Yan, Lin
err分享
err收藏
Revolutionizing sepsis therapy: Machine learning-driven co-crystallization reveals emodin's therapeutic potential革命性脓毒症疗法：机器学习驱动的共结晶揭示了emodin的 therapeutic potential
errChinese Chemical Letters
IF8.9
err2025-05-08
err0
PREAI
errShuang Li; Penghui Yuan; Xinyi Zhang; Meiru Liu; Dezhi Yang; Linglei Kong; Li Zhang; Yang Lu; Guanhua Du
err分享
err收藏
Combining Metabolomics and Quantitative Analysis to Investigate Purine Metabolism Disorders in Depression and the Therapeutic Effect of Chaigui Granules结合代谢组学与定量分析探讨抑郁症中嘌呤代谢紊乱及柴归颗粒的 therapeutic effect
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2025-04-10
err0
PREAI
errHuang, DH; Lv, JL; Gong, WX; Tian, JS; Gao, XX; Qin, XM; Du, GH; Zhou, YZ
err分享
err收藏
7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death7 I，一种结构修饰的青风藤碱，通过抑制胶质母细胞瘤增殖和诱导坏死性凋亡，发挥双重抗GBM效应，进而介导溶酶体细胞死亡
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2025-03-04
err2
PREAI
errYang, Hong; Jiang, Bin; Li, Wan; Du, Guanhua; Xu, Fang; Zhang, Yizhi; Yang, Yihui; Zhang, Sen; Cao, Wanxin; Li, Xiaoxue; Zhang, Xu; Ji, Tengfei; Wang, Jinhua
err分享
err收藏
Exosomes-encapsulated biomimetic polydopamine carbon dots with dual-targeting effect alleviate motor and non-motor symptoms of Parkinson's disease via anti-neuroinflammation外泌体封装的仿生聚多巴胺碳点通过抗神经炎症缓解帕金森病的运动和非运动症状
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2025-03-01
err2
PREAI
errYang, Chen; Song, Yanhao; Luo, Mingkai; Wang, Qiuli; Zhang, Yumei; Cen, Juan; Du, Guanhua; Shi, Jiahua
err分享
err收藏
Targeted Lipidomics and Transcriptomics Unveil Aberrant Lipid Metabolic Remodeling in Visceral and Subcutaneous Adipose Tissue under ER Stress
errJOURNAL OF PROTEOME RESEARCH
IF3.6
err2025-03-01
err0
PREAI
errHe, Ping; Zhang, Li; Ma, Peng; Xu, Tianshu; Wang, Zijing; Li, Li; Du, Guanhua; Qiang, Guifen; Liu, Cuiqing
err分享
err收藏

研究方向

药物发现高通量药物筛选神经药理学和心脑血管药理学研究
合作学者
合作期刊
朱丽丽 封面图
朱丽丽 (Li Zhu)
H 指数: 175 · 论文数: 7.6K
E
Erik De Clercq
H 指数: 162 · 论文数: 4.0K
张
张丽 (Li Zhang)
H 指数: 121 · 论文数: 2.6K
王
王锐 (Rui Wang)
H 指数: 117 · 论文数: 2.1K
D
Dave S.�B. Hoon
H 指数: 108 · 论文数: 799
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