Takuya Kobayakawa

Institute of Science Tokyo

H指数:14

被引数:673

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荣誉奖项

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Identification of novel diimide and hydrazone scaffolds for synergistic HIV-1 shock and kill strategies

新型二亚胺和腙类骨架在协同HIV-1冲击与清除策略中的鉴定

Biochemical and Biophysical Research Communications

IF2.2

2026-09-110

OAAI

CD4 Mimic-Neutralizing Antibody Conjugates Synthesized by Site-Specific Modification Methods as HIV-1 Entry Inhibitors

通过位点特异性修饰方法合成的CD4模拟-中和抗体偶联物作为HIV-1进入抑制剂

ChemMedChem

IF3.4

2026-02-120

PRE

Front Cover: Hybrid Molecules of Small Molecular and Peptidic HIV Fusion Inhibitors (ChemBioChem 13/2025)

封面：小分子和肽类HIV融合抑制剂的杂化分子 (ChemBioChem 13/2025)

ChemBioChem

IF2.8

2025-07-110

PRE

Hybrid Molecules of Small Molecular and Peptidic HIV Fusion Inhibitors

小分子和肽类HIV融合抑制剂的杂合分子

CHEMBIOCHEM

IF2.8

2025-05-140

PRE

An orally available P1′-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier

PNAS NEXUS

IF3.8

2025-01-070

OAAI

Higashi-Kuwata, Nobuyo; Bulut, Haydar; Hayashi, Hironori; Tsuji, Kohei; Ogata-Aoki, Hiromi; Kiso, Maki; Takamune, Nobutoki; Kishimoto, Naoki; Hattori, Shin-ichiro; Ishii, Takahiro; Kobayakawa, Takuya; Nakano, Kenta; Shimizu, Yukiko; Das, Debananda; Saruwatari, Junji; Hasegawa, Kazuya; Murayama, Kazutaka; Sukenaga, Yoshikazu; Takamatsu, Yuki; Yoshimura, Kazuhisa; Aoki, Manabu; Furusawa, Yuri; Okamura, Tadashi; Yamayoshi, Seiya; Kawaoka, Yoshihiro; Misumi, Shogo; Tamamura, Hirokazu; Mitsuya, Hiroaki

Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing chiral auxiliaries

利用手性辅助剂对(Z)-氟代烯烃二肽异构体进行立体选择性合成

ORGANIC & BIOMOLECULAR CHEMISTRY

IF2.7

2025-01-010

PRE

Naphthalen-1-ylethanamine-containing small molecule inhibitors of the papain-like protease of SARS-CoV-2

SARS-CoV-2木瓜蛋白酶类蛋白酶的Naphthalen-1-ylethanamine-containing小分子抑制剂

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-12-010

PRE

Design, synthesis and evaluation of bioactivity of peptidomimetics based on chloroalkene dipeptide isosteres

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2024-08-012

PRE

Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents

发现有效的DAG-内酯衍生物作为HIV潜伏期逆转剂

ACS INFECTIOUS DISEASES

IF3.8

2024-05-212

PRE

Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-09-2710

PRE

Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-08-019

OAAI

Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

NATURE COMMUNICATIONS

IF15.7

2023-02-2524

OAAI

Higashi-Kuwata, Nobuyo; Tsuji, Kohei; Hayashi, Hironori; Bulut, Haydar; Kiso, Maki; Imai, Masaki; Ogata-Aoki, Hiromi; Ishii, Takahiro; Kobayakawa, Takuya; Nakano, Kenta; Takamune, Nobutoki; Kishimoto, Naoki; Hattori, Shin-ichiro; Das, Debananda; Uemura, Yukari; Shimizu, Yosuke; Aoki, Manabu; Hasegawa, Kazuya; Suzuki, Satoshi; Nishiyama, Akie; Saruwatari, Junji; Shimizu, Yukiko; Sukenaga, Yoshikazu; Takamatsu, Yuki; Tsuchiya, Kiyoto; Maeda, Kenji; Yoshimura, Kazuhisa; Iida, Shun; Ozono, Seiya; Suzuki, Tadaki; Okamura, Tadashi; Misumi, Shogo; Kawaoka, Yoshihiro; Tamamura, Hirokazu; Mitsuya, Hiroaki

Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates

抗HIV-1临床分离株的新型CD4模拟化合物YIR-821的表征

JOURNAL OF VIROLOGY

IF3.8

2023-01-312