I.J. Clifton

University of Oxford

H指数:38

被引数:7,535

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Unanticipated intermediates during isopenicillin N synthase catalysis identified by time-resolved X-ray free-electron laser studies

异噁唑霉素N合成酶催化过程中通过时间分辨X射线自由电子激光研究鉴定出的非预期中间体

Nature Catalysis

IF44.6

2026-10-090

OAAI

Patrick Rabe; Hiroki Makita; Rebecca Southwart; Midhun George Thomas; Mihails Kazaks; Shyam Basak; Tiankun Zhou; William K. Myers; Margaret D. Doyle; Philipp S. Simon; Shusaku Hayama; J. Frederick W. Mosselmans; Alexander T. Stead; Abraham O. Oluwole; Malkit Sami; Ian Clifton; Pierre Aller; Asmit Bhowmick; Anthony Tumber; Jos J. A. G. Kamps; Karina Calvopiña; Agata Butryn; Robert Bosman; Arjun Cheema; Jordan Welsh; James D. S. Linyard; Frederick J. H. Foster; Pauline A. Lang; Mariska de Munnik; Stephen M. Keable; Medhanjali Dasgupta; In-Sik Kim; Isabel Bogacz; Kuntal Chatterjee; Kyle D. Sutherlin; Corey J. Kaminsky; Jürgen Brem; Michael A. McDonough; Christina Redfield; James R. D. Montgomery; Coral Mycroft; Anastasya Shilova; Nicholas Devenish; Frederic P. Poitevin; Sebastian Dehe; Vandana Tiwari; Humberto Sanchez; Daniel J. Rosenberg; Mark S. Hunter; Leland B. Gee; Uwe Bergmann; Roberto Alonso-Mori; Jaehyun Park; Shigeki Owada; Kensuke Tono; Danny Axford; Robin L. Owen; Daniel W. Paley; Nicholas K. Sauter; David Mittan-Moreau; Aaron S. Brewster; Carol V. Robinson; Vittal K. Yachandra; Junko Yano; Edgars Suna; Christo Z. Christov; Allen M. Orville; Jan F. Kern; Christopher J. Schofield

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-09-013

OAAI

Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors

NATURE COMMUNICATIONS

IF15.7

2022-08-1525

OAAI

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

SCIENCE ADVANCES

IF12.5

2021-08-2034

OAAI

Rabe, Patrick; Kamps, Jos J. A. G.; Sutherlin, Kyle D.; Linyard, James D. S.; Aller, Pierre; Pham, Cindy C.; Makita, Hiroki; Clifton, Ian; McDonough, Michael A.; Leissing, Thomas M.; Shutin, Denis; Lang, Pauline A.; Butryn, Agata; Brem, Jurgen; Gul, Sheraz; Fuller, Franklin D.; Kim, In-Sik; Cheah, Mun Hon; Fransson, Thomas; Bhowmick, Asmit; Young, Iris D.; O'Riordan, Lee; Brewster, Aaron S.; Pettinati, Ilaria; Doyle, Margaret; Joti, Yasumasa; Owada, Shigeki; Tono, Kensuke; Batyuk, Alexander; Hunter, Mark S.; Alonso-Mori, Roberto; Bergmann, Uwe; Owen, Robin L.; Sauter, Nicholas K.; Claridge, Timothy D. W.; Robinson, Carol V.; Yachandra, Vittal K.; Yano, Junko; Kern, Jan F.; Orville, Allen M.; Schofield, Christopher J.

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2017-08-2114

OAAI

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition

CHEMICAL COMMUNICATIONS

IF4.2

2017-01-0130

OAAI

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

CHEMICAL SCIENCE