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J

Jürgen Brem

University of Oxford
H指数:35
被引数:3,740

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Unanticipated intermediates during isopenicillin N synthase catalysis identified by time-resolved X-ray free-electron laser studies

异噁唑霉素N合成酶催化过程中通过时间分辨X射线自由电子激光研究鉴定出的非预期中间体

Nature Catalysis
IF44.6
2026-10-090
OAAI
Patrick Rabe; Hiroki Makita; Rebecca Southwart; Midhun George Thomas; Mihails Kazaks; Shyam Basak; Tiankun Zhou; William K. Myers; Margaret D. Doyle; Philipp S. Simon; Shusaku Hayama; J. Frederick W. Mosselmans; Alexander T. Stead; Abraham O. Oluwole; Malkit Sami; Ian Clifton; Pierre Aller; Asmit Bhowmick; Anthony Tumber; Jos J. A. G. Kamps; Karina Calvopiña; Agata Butryn; Robert Bosman; Arjun Cheema; Jordan Welsh; James D. S. Linyard; Frederick J. H. Foster; Pauline A. Lang; Mariska de Munnik; Stephen M. Keable; Medhanjali Dasgupta; In-Sik Kim; Isabel Bogacz; Kuntal Chatterjee; Kyle D. Sutherlin; Corey J. Kaminsky; Jürgen Brem; Michael A. McDonough; Christina Redfield; James R. D. Montgomery; Coral Mycroft; Anastasya Shilova; Nicholas Devenish; Frederic P. Poitevin; Sebastian Dehe; Vandana Tiwari; Humberto Sanchez; Daniel J. Rosenberg; Mark S. Hunter; Leland B. Gee; Uwe Bergmann; Roberto Alonso-Mori; Jaehyun Park; Shigeki Owada; Kensuke Tono; Danny Axford; Robin L. Owen; Daniel W. Paley; Nicholas K. Sauter; David Mittan-Moreau; Aaron S. Brewster; Carol V. Robinson; Vittal K. Yachandra; Junko Yano; Edgars Suna; Christo Z. Christov; Allen M. Orville; Jan F. Kern; Christopher J. Schofield
Development of Water-Trapping Pyrrole-2-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors

水捕获吡咯-2-羧酸类化合物的开发作为广谱金属β-内酰胺酶抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-05-140
OA
Monisha Singha; Liam A. Wilson; Elisabete C. C. M. Moura; Maria M. Trush; Karina Calvopina; Gurleen Kaur; Greta Zaborskytė; Toms Kalniņš; Tharindi Panduwawala; Matthew J. Bowen; Matthew J. Beech; Jürgen Brem; Peter J. McHugh; Edgars Suna; Timothy R. Walsh; Christopher J. Schofield; Alistair J. M. Farley
Filamin C dimerisation is regulated by HSPB7

Filamin C二聚化由HSPB7调控。

NATURE COMMUNICATIONS
IF15.7
2025-05-010
OA
Wang, Zihao; Cao, Guodong; Collier, Miranda P.; Qiu, Xingyu; Broadway-Stringer, Sophie; Saman, Dominik; Ng, Jediael Z. Y.; Sen, Navoneel; Azad, Amar J.; Hooper, Charlotte; Zimmermann, Johannes; Mcdonough, Michael A.; Brem, Juergen; Rabe, Patrick; Song, Haigang; Alderson, T. Reid; Schofield, Christopher J.; Bolla, Jani R.; Djinovic-Carugo, Kristina; Fuerst, Dieter O.; Warscheid, Bettina; Degiacomi, Matteo T.; Allison, Timothy M.; Hochberg, Georg K. A.; Robinson, Carol V.; Gehmlich, Katja; Benesch, Justin L. P.
The Triple Combination of Meropenem, Avibactam, and a Metallo-(3-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different (3-Lactamase Producers
ENGINEERING
IF11.6
2024-07-011
OAAI
Ling, Zhuoren; Farley, Alistair James Macdonald; Lankapalli, Aditya; Zhang, Yanfang; Premchand-Branker, Shonnette; Cook, Kate; Baran, Andrei; Gray-Hammerton, Charlotte; Rubio, Claudia Orbegozo; Suna, Edgars; Mathias, Jordan; Brem, Jurgen; Sands, Kirsty; Nieto-Rosado, Maria; Trush, Maria Mykolaivna; Rakhi, Nadira Naznin; Martins, Willames; Zhou, Yuqing; Schofield, Christopher Joseph; Walsh, Timothy
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target
CHEMICAL SCIENCE
IF7.4
2024-01-010
OAAI
Bielinski, Marcin; Henderson, Lucy R.; Yosaatmadja, Yuliana; Swift, Lonnie P.; Baddock, Hannah T.; Bowen, Matthew J.; Brem, Jurgen; Jones, Philip S.; Mcelroy, Stuart P.; Morrison, Angus; Speake, Michael; van Boeckel, Stan; van Doornmalen, Els; van Groningen, Jan; van den Hurk, Helma; Gileadi, Opher; Newman, Joseph A.; Mchugh, Peter J.; Schofield, Christopher J.
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

模仿 β-内酰胺结合可实现广谱金属 β-内酰胺酶抑制剂

NATURE CHEMISTRY
IF20.2
2021-12-1342
PRE
Brem, Jurgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne; Liepins, Edgars; Donets, Pawel; Espina, Laura; Farley, Alistair J. M.; Shubin, Kirill; Campillos, Gonzalo Gomez; Kiuru, Paula; Shishodia, Shifali; Krahn, Daniel; Lesniak, Robert K.; Schmidt (Adrian), Juliane; Calvopina, Karina; Turrientes, Maria-Carmen; Kavanagh, Madeline E.; Lubriks, Dmitrijs; Hinchliffe, Philip; Langley, Gareth W.; Aboklaish, Ali F.; Eneroth, Anders; Backlund, Maria; Baran, Andrei G.; Nielsen, Elisabet, I; Speake, Michael; Kuka, Janis; Robinson, John; Grinberga, Solveiga; Robinson, Lindsay; McDonough, Michael A.; Rydzik, Anna M.; Leissing, Thomas M.; Jimenez-Castellanos, Juan Carlos; Avison, Matthew B.; Pinto, Solange Da Silva; Pannifer, Andrew D.; Martjuga, Marina; Widlake, Emma; Priede, Martins; Navratilova, Iva Hopkins; Gniadkowski, Marek; Belfrage, Anna Karin; Brandt, Peter; Yli-Kauhaluoma, Jari; Bacque, Eric; Page, Malcolm G. P.; Bjorkling, Fredrik; Tyrrell, Jonathan M.; Spencer, James; Lang, Pauline A.; Baranczewski, Pawel; Canton, Rafael; McElroy, Stuart P.; Jones, Philip S.; Baquero, Fernando; Suna, Edgars; Morrison, Angus; Walsh, Timothy R.; Schofield, Christopher J.
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
SCIENCE ADVANCES
IF12.5
2021-08-2034
OAAI
Rabe, Patrick; Kamps, Jos J. A. G.; Sutherlin, Kyle D.; Linyard, James D. S.; Aller, Pierre; Pham, Cindy C.; Makita, Hiroki; Clifton, Ian; McDonough, Michael A.; Leissing, Thomas M.; Shutin, Denis; Lang, Pauline A.; Butryn, Agata; Brem, Jurgen; Gul, Sheraz; Fuller, Franklin D.; Kim, In-Sik; Cheah, Mun Hon; Fransson, Thomas; Bhowmick, Asmit; Young, Iris D.; O'Riordan, Lee; Brewster, Aaron S.; Pettinati, Ilaria; Doyle, Margaret; Joti, Yasumasa; Owada, Shigeki; Tono, Kensuke; Batyuk, Alexander; Hunter, Mark S.; Alonso-Mori, Roberto; Bergmann, Uwe; Owen, Robin L.; Sauter, Nicholas K.; Claridge, Timothy D. W.; Robinson, Carol V.; Yachandra, Vittal K.; Yano, Junko; Kern, Jan F.; Orville, Allen M.; Schofield, Christopher J.
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
NATURE COMMUNICATIONS
IF15.7
2021-07-2241
OAAI
Butryn, Agata; Simon, Philipp S.; Aller, Pierre; Hinchliffe, Philip; Massad, Ramzi N.; Leen, Gabriel; Tooke, Catherine L.; Bogacz, Isabel; Kim, In-Sik; Bhowmick, Asmit; Brewster, Aaron S.; Devenish, Nicholas E.; Brem, Jurgen; Kamps, Jos J. A. G.; Lang, Pauline A.; Rabe, Patrick; Axford, Danny; Beale, John H.; Davy, Bradley; Ebrahim, Ali; Orlans, Julien; Storm, Selina L. S.; Zhou, Tiankun; Owada, Shigeki; Tanaka, Rie; Tono, Kensuke; Evans, Gwyndaf; Owen, Robin L.; Houle, Frances A.; Sauter, Nicholas K.; Schofield, Christopher J.; Spencer, James; Yachandra, Vittal K.; Yano, Junko; Kern, Jan F.; Orville, Allen M.

研究方向

暂未获取到该数据
C
Christopher J. Schofield
H 指数:112论文数:1,313被引数:6.2万
J
James Spencer
H 指数:60论文数:326被引数:1.6万
M
M.A. McDonough
H 指数:55论文数:282被引数:1.2万
P
Philip Hinchliffe
H 指数:27论文数:96被引数:3,985
P
Pauline A. Lang
H 指数:14论文数:34被引数:816
A
Anna M. Rydzik
H 指数:25论文数:57被引数:1,734
T
Timothy D. W. Claridge
H 指数:62论文数:521被引数:1.5万
K
Karina Calvopiña
H 指数:15论文数:35被引数:695
P
Patrick Rabe
H 指数:32论文数:101被引数:2,991
C
Catherine L. Tooke
H 指数:16论文数:44被引数:1,873