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Y

Yafeng Xue

AstraZeneca
H指数:33
被引数:3,260

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Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15–GFRaL–RET Complex Cell Signaling

双环肽串联的设计：模拟同源二聚体GDF15蛋白以抑制GDF15–GFRaL–RET复合物细胞信号传导

Journal of Medicinal Chemistry
IF6.8
2025-10-090
PRE
Anaïs F. M. Noisier; Jenny Sandmark; Fredrik Edfeldt; Anna Backmark; Johan Broddefalk; Joanna Wandzik; Ulrik Jurva; Margareta Ek; Carina A. Johansson; Louise Barlind; Jenny Gunnarsson; Janna M. Bigalke; Yafeng Xue; Andrey I. Frolov; Cecilia Kankkonen; Robert G. Roth; Maria Fritsch; Sophie Watcham; Katerine van Rietschoten; Gemma E. Mudd; Helen Harrison; Liuhong Chen; Michael J. Skynner; David J. Craik; Sunay V. Chankeshwara; Malin Lemurell
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors

嘧啶并吡啶酮系列IRAK4抑制剂的鉴定和优化

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2022-06-012
PRE
Cumming, Iain A.; Degorce, Sebastien L.; Aagaard, Anna; Braybrooke, Erin L.; Davies, Nichola L.; Diene, Coura R.; Eatherton, Andrew J.; Felstead, Hannah R.; Groombridge, Sam D.; Lenz, Eva M.; Li, Yunxia; Nai, Youfeng; Pearson, Stuart; Robb, Graeme R.; Scott, James S.; Steward, Oliver R.; Wu, Chengyan; Xue, Yafeng; Zhang, Lanping; Zhang, Yanxiu
AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-08-3111
PRE
Narjes, Frank; Llinas, Antonio; von Berg, Stefan; Jirholt, Johan; Lever, Sarah; Pehrson, Rikard; Collins, Mia; Malmberg, Anna; Svanberg, Petter; Xue, Yafeng; Olsson, Roine, I; Malmberg, Jesper; Hughes, Glyn; Hossain, Nafizal; Grindebacke, Hanna; Leffler, Agnes; Krutrok, Nina; Back, Elisabeth; Ramnegard, Marie; Lepisto, Matti; Thunberg, Linda; Aagaard, Anna; McPheat, Jane; Hansson, Eva L.; Chen, Rongfeng; Xiong, Yao; Hansson, Thomas G.
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2020-12-014
PREAI
Degorce, Sebastien L.; Aagaard, Anna; Anjum, Rana; Cumming, Iain A.; Diene, Coura R.; Fallan, Charlene; Johnson, Tony; Leuchowius, Karl-Johan; Orton, Alexandra L.; Pearson, Stuart; Robb, Graeme R.; Rosen, Alan; Scarfe, Graeme B.; Scott, James S.; Smith, James M.; Steward, Oliver R.; Terstiege, Ina; Tucker, Michael J.; Turner, Paul; Wilkinson, Stephen D.; Wrigley, Gail L.; Xue, Yafeng
Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2019-05-2921
OAAI
von Berg, Stefan; Xue, Yafeng; Collins, Mia; Llinas, Antonio; Olsson, Roine I.; Halvarsson, Torbjorn; Lindskog, Maria; Malmberg, Jesper; Jirholt, Johan; Krutrok, Nina; Ramnegard, Marie; Brannstrom, Marie; Lundqvist, Anders; Lepisto, Matti; Aagaard, Anna; McPheat, Jane; Hansson, Eva L.; Chen, Rongfeng; Xiong, Yao; Hansson, Thomas G.; Narjes, Frank
Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-08-1031
PREAI
Narjes, Frank; Xue, Yafeng; von Berg, Stefan; Malmberg, Jesper; Llinas, Antonio; Olsson, Rome, I; Jirholt, Johan; Grindebacke, Hanna; Leffler, Agnes; Hossain, Nafizal; Lepisto, Matti; Thunberg, Linda; Leek, Hanna; Aagaard, Anna; McPheat, Jane; Hansson, Eva L.; Back, Elisabeth; Tangefjord, Stefan; Chen, Rongfeng; Yao Xiong; Ge Hongbin; Hansson, Thomas G.
Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity

基于结构的盐皮质激素受体拮抗剂药物设计探索氧类固醇受体选择性

CHEMMEDCHEM
IF3.4
2016-12-1511
OAAI
Nordqvist, Anneli; O'Mahony, Gavin; Friden-Saxin, Maria; Fredenwall, Marlene; Hogner, Anders; Granberg, Kenneth L.; Aagaard, Anna; Backstrom, Stefan; Gunnarsson, Anders; Kaminski, Tim; Xue, Yafeng; Dellsen, Anita; Hansson, Eva; Hansson, Pia; Ivarsson, Ida; Karlsson, Ulla; Bamberg, Krister; Hermansson, Majlis; Georgsson, Jennie; Lindmark, Bo; Edman, Karl
Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-06-0468
PREAI
Oza, Vibha; Ashwell, Susan; Almeida, Lynsie; Brassil, Patrick; Breed, Jason; Deng, Chun; Gero, Thomas; Grondine, Michael; Horn, Candice; Ioannidis, Stephanos; Liu, Dongfang; Lyne, Paul; Newcombe, Nicholas; Pass, Martin; Read, Jon; Ready, Shannon; Rowsell, Sian; Su, Mei; Toader, Dorin; Vasbinder, Melissa; Yu, Dingwei; Yu, Yan; Xue, Yafeng; Zabludoff, Sonya; Janetka, James

研究方向

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A
Anna Aagaard
H 指数:27论文数:63被引数:1,891
S
Stefan von Berg
H 指数:21论文数:50被引数:2,163
S
Sébastien L. Degorce
H 指数:19论文数:74被引数:1,176
J
James S. Scott
H 指数:51论文数:350被引数:8,478
E
Eva Hansson
H 指数:17论文数:40被引数:674
F
Frank Narjes
H 指数:33论文数:99被引数:2,930
L
Linda Öster
H 指数:18论文数:57被引数:864
G
Graeme R. Robb
H 指数:25论文数:70被引数:2,043
Y
Yao Xiong
H 指数:20论文数:73被引数:1,446
J
Jane McPheat
H 指数:17论文数:24被引数:795