logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
S

Sébastien L. Degorce

GlaxoSmithKline
H指数:19
被引数:1,176

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

AI-assisted delivery of novel covalent WRN inhibitors from a non-covalent fragment screen

AI辅助的新型共价WRN抑制剂的非共价片段筛选递送

Bioorganic & Medicinal Chemistry Letters
IF2.2
2025-09-300
PRE
Geoffrey M.T. Smith; Laksh Aithani; Charlotte E. Barrett; Alwin O. Bucher; Christopher D.O. Cooper; Sébastien L. Degorce; Andrew S. Doré; Catherine T. Fletcher; Sophie Huber; Rosemary Huckvale; Amanda J. Kennedy; Abigail A. Mornement; Mark Pickworth; Prakash Rucktooa; Conor C.G. Scully; Sarah E. Skerratt
Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-12-100
PRE
Johannes, Jeffrey W.; Balazs, Amber Y. S.; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, SebastienL.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin J.; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie J. B.; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Mcwilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andy; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan
Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1

刚性蛋白-蛋白相互作用抑制剂的设计使得靶向不可服用的Mcl-1成为可能

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2023-05-152
OAAI
Hargreaves, David; Carbajo, Rodrigo J.; Bodnarchuk, Michael S.; Embrey, Kevin; Rawlins, Philip B.; Packer, Martin; Degorce, Sebastien L.; Hird, Alexander W.; Johannes, Jeffrey W.; Chiarparin, Elisabetta; Schade, Markus
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors

嘧啶并吡啶酮系列IRAK4抑制剂的鉴定和优化

BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2022-06-012
PRE
Cumming, Iain A.; Degorce, Sebastien L.; Aagaard, Anna; Braybrooke, Erin L.; Davies, Nichola L.; Diene, Coura R.; Eatherton, Andrew J.; Felstead, Hannah R.; Groombridge, Sam D.; Lenz, Eva M.; Li, Yunxia; Nai, Youfeng; Pearson, Stuart; Robb, Graeme R.; Scott, James S.; Steward, Oliver R.; Wu, Chengyan; Xue, Yafeng; Zhang, Lanping; Zhang, Yanxiu
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-2781
PREAI
Johannes, Jeffrey W.; Balazs, Amber; Barratt, Derek; Bista, Michal; Chuba, Matthew D.; Cosulich, Sabina; Critchlow, Susan E.; Degorce, Sebastien L.; Di Fruscia, Paolo; Edmondson, Scott D.; Embrey, Kevin; Fawell, Stephen; Ghosh, Avipsa; Gill, Sonja J.; Gunnarsson, Anders; Hande, Sudhir M.; Heightman, Tom D.; Hemsley, Paul; Illuzzi, Giuditta; Lane, Jordan; Larner, Carrie; Leo, Elisabetta; Liu, Lina; Madin, Andrew; Martin, Scott; McWilliams, Lisa; O'Connor, Mark J.; Orme, Jonathan P.; Pachl, Fiona; Packer, Martin J.; Pei, Xiaohui; Pike, Andrew; Schimpl, Marianne; She, Hongyao; Staniszewska, Anna D.; Talbot, Verity; Underwood, Elizabeth; Varnes, Jeffrey G.; Xue, Lin; Yao, Tieguang; Zhang, Ke; Zhang, Andrew X.; Zheng, Xiaolan
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2020-12-014
PREAI
Degorce, Sebastien L.; Aagaard, Anna; Anjum, Rana; Cumming, Iain A.; Diene, Coura R.; Fallan, Charlene; Johnson, Tony; Leuchowius, Karl-Johan; Orton, Alexandra L.; Pearson, Stuart; Robb, Graeme R.; Rosen, Alan; Scarfe, Graeme B.; Scott, James S.; Smith, James M.; Steward, Oliver R.; Terstiege, Ina; Tucker, Michael J.; Turner, Paul; Wilkinson, Stephen D.; Wrigley, Gail L.; Xue, Yafeng
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-07-3154
OAAI
Karlin, Jeremy; Allen, Jasmine; Ahmad, Syed F.; Hughes, Gareth; Sheridan, Victoria; Odedra, Rajesh; Farrington, Paul; Cadogan, Elaine B.; Riches, Lucy C.; Garcia-Trinidad, Antonio; Thomason, Andrew G.; Patel, Bhavika; Vincent, Jennifer; Lau, Alan; Pike, Kurt G.; Hunt, Thomas A.; Sule, Amrita; Valerie, Nicholas C. K.; Biddlestone-Thorpe, Laura; Kahn, Jenna; Beckta, Jason M.; Mukhopadhyay, Nitai; Barlaam, Bernard; Degorce, Sebastien L.; Kettle, Jason; Colclough, Nicola; Wilson, Joanne; Smith, Aaron; Barrett, Ian P.; Zheng, Li; Zhang, Tianwei; Wang, Yingchun; Chen, Kan; Pass, Martin; Durant, Stephen T.; Valerie, Kristoffer
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-04-23101
OAAI
Pike, Kurt G.; Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Chen, Yingxue; Colclough, Nicola; Davies, Nichola L.; de-Almeida, Camila; Degorce, Sebastien L.; Didelot, Myriam; Dishington, Allan; Ducray, Richard; Durant, Stephen T.; Hassall, Lorraine A.; Holmes, Jane; Hughes, Gareth D.; MacFaul, Philip A.; Mulholland, Keith R.; McGuire, Thomas M.; Ouvry, Gilles; Pass, Martin; Robb, Graeme; Stratton, Natalie; Wang, Zhenhua; Wilson, Joanne; Zhai, Baochang; Zhao, Kang; Al-Huniti, Nidal
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-12-1164
PREAI
Scott, James S.; Degorce, Sebastien L.; Anjum, Rana; Culshaw, Janet; Davies, Robert D. M.; Davies, Nichola L.; Dillman, Keith S.; Dowling, James E.; Drew, Lisa; Ferguson, Andrew D.; Groombridge, Sam D.; Halsall, Christopher T.; Hudson, Julian A.; Lamont, Scott; Lindsay, Nicola A.; Marden, Stacey K.; Mayo, Michele F.; Pease, J. Elizabeth; Perkins, David R.; Pink, Jennifer H.; Robb, Graeme R.; Rosen, Alan; Shen, Minhui; McWhirter, Claire; Wu, Dedong

研究方向

暂未获取到该数据
J
James S. Scott
H 指数:51论文数:350被引数:8,478
J
Jennifer H. Pink
H 指数:23论文数:63被引数:1,497
G
Graeme R. Robb
H 指数:25论文数:70被引数:2,043
B
Bernard Barlaam
H 指数:24论文数:100被引数:1,893
R
Richard Ducray
H 指数:15论文数:50被引数:779
S
Sam D. Groombridge
H 指数:14论文数:36被引数:611
Y
Yafeng Xue
H 指数:33论文数:77被引数:3,260
I
Iain Cumming
H 指数:12论文数:28被引数:550
E
Elaine Cadogan
H 指数:26论文数:128被引数:2,860
A
Andrew Bailey
H 指数:27论文数:75被引数:3,761