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Li Gan

weill cornell medicine

75H指数
332论文数
1.8W被引数
收录论文 106
发表时间
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Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction具有缩短端粒的衰老小胶质细胞分泌可溶性DLK1以诱导与年龄相关的脱髓鞘和神经元功能障碍
errNeuron
IF15
err2026-08-11
err0
PREAI
errBangyan Liu; Matthew Mahoney; Yilin Feng; Maria Telpoukhovskaia; Alice Maria Giani; Eileen Ruth Torres; Lihong Zhan; Pearly Ye; Jingjie Zhu; Nessa R. Foxe; Daphne Zhu; Xinran Tong; Deepak Srivastava; Christina V. Theodoris; Shiaoching Gong; Mingrui Zhao; Li Fan; Li Gan
err分享
err收藏
cGAS-mediated type I IFN signaling contributes to disease progression in drug-refractory epilepsycGAS介导的I型IFN信号通路促进耐药性癫痫疾病进展
errNature Neuroscience
IF20
err2026-07-29
err0
errOAAI
errYige Huang; Li Fan; Man Ying Wong; Zhuofan Lei; Balaji Krishnamachary; Daphne Zhu; Mika P. Cadiz; Ravi Kumar Nagiri; Pearly Ye; Kendra Norman; Maitreyee Bhagwat; Young Jae Lee; Hui Li; Jingjie Zhu; Sadaf Amin; Kelli Lauderdale; Hao Chen; Wenjie Luo; Shiaoching Gong; Benjamin L. Liechty; Jorge J. Palop; Subhash C. Sinha; Junfang Wu; Mingrui Zhao; Li Gan
err分享
err收藏
Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice人源iPSC来源的小胶质细胞移植可改善粒细胞缺乏小鼠的神经病理学和回路功能障碍
errMolecular Neurodegeneration
IF17.5
err2026-07-16
err0
errOAAI
errHayk Davtyan; Sarah Naguib; Yuliya Voskobiynyk; Jean Paul Chadarevian; Joia K. Capocchi; Jeannie L. Giacchino; Ghazaleh Eskandari-Sedighi; Vivianna DeNittis; Jeremy B. Ford; Ani Agababian; Jasmine Nguyen; Alina L. Chadarevian; Madison S. Sutherland; Sepideh Kiani Shabestari; Kayla Tran; Bret Holt; Alissa L. Nana; Jiasheng Zhang; Salvatore Spina; Man Ying Wong; Lea T. Grinberg; William W. Seeley; Eric Huang; Claire D. Clelland; Shiaoching Gong; Li Fan; Jeanne T. Paz; Mathew Blurton-Jones; Li Gan
err分享
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Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology减少的ULK1连接受损的自噬和线粒体自噬与阿尔茨海默病病理
errNature Aging
IF19.4
err2026-05-14
err0
errOAAI
errJun-Ping Pan; Ping-Jie Wang; Jianying Zhang; Anne-Brita Knapskog; Leiv Otto Watne; He-Ling Wang; Maria Jose Lagartos-Donate; Sofie Lautrup; Li-Peng Mao; Qian Wang; Zhi-Peng Ling; Shi-qi Zhang; Tomás Schmauck-Medina; Ruixue Ai; Trine Holt Edwin; Tianjiao Zhang; Ingvild Saltvedt; Rannveig Sakshaug Eldholm; Annabel Smith; Kateřina Veverová; Domenica Caponio; Asgeir Kobro-Flatmoen; Huanhuan Pang; Zijian Wang; Haoyun Wang; Li-juan Gao; Nathalie Bodd Halaas; Garry Wong; Martin Vyhnalek; Oscar Junhong Luo; William A. McEwan; Jon Storm-Mathisen; Li Gan; Zeping Hu; Henrik Zetterberg; Menno P. Witter; Dag Aarsland; Geir Selbæk; Guobing Chen; Evandro Fei Fang
err分享
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An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration乙酰化Tau-174 CSF生物标志物区分额颞叶变性患者的TDP-43和tau病理
errNature Medicine
IF50
err2026-04-15
err0
errOAAI
errMadison I. J. Honey; Yanaika S. Hok-A-Hin; Elisabeth H. Thijssen; Katheryn A. Q. Cousins; Babette van der Weijden; Lisanne in ‘t Veld; Erik Stoops; Sterre C. M. de Boer; Flora H. Duits; Julie F. H. de Houwer; Tjado H. J. Morrema; Daniel Alcolea; Ignacio Illán-Gala; Juan Fortea; Alberto Lleó; Adam L. Boxer; David J. Irwin; Edward B. Lee; Leslie Shaw; Corey T. McMillan; David A. Wolk; Jeroen J. M. Hoozemans; Wiesje M. van der Flier; Emma van der Ende; Harro Seelaar; Inge M. W. Verberk; Li Gan; Yolande Pijnenburg; Charlotte E. Teunissen
err分享
err收藏
DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy miceDAP12基因缺失降低雌性tau病小鼠的神经元SLIT2和脱髓鞘，并增强其大脑的恢复力。
errMolecular Neurodegeneration
IF17.5
err2025-12-02
err0
errOAAI
errHao Chen; Li Fan; Qi Guo; Man Ying Wong; Jingjie Zhu; Nessa Foxe; Winston Wang; Aviram Nessim; Gillian Carling; Bangyan Liu; Chloe Lopez-Lee; Yige Huang; Sadaf Amin; Tark Patel; Sue-Ann Mok; Won-min Song; Bin Zhang; Shiaoching Gong; Qin Ma; Hongjun Fu; Li Gan; Wenjie Luo
err分享
err收藏
Unveiling risk factors and predicting osteoporosis through bone density based aging model: a community-based cohort in Guangdong, China通过基于骨密度的老化模型揭示风险因素并预测骨质疏松症：一项来自中国广东省的社区队列研究
errBMC MUSCULOSKELETAL DISORDERS
IF2.4
err2025-11-14
err0
errOAAI
errTan, Jinhong; Zhu, Jijun; He, Yongtao; Fan, Zhaohao; Cai, Fuqiang; Zhuang, Haowen; Hu, Yanhua; Liu, Kangyan; Li, Qiancheng; Feng, Bo; Guo, Yushi; Li, Gan; Wang, Bin; Chen, Junfang
err分享
err收藏
Trained Immunity in Health and Disease健康与疾病中的训练性免疫
errMedComm
IF10.7
err2025-11-06
err0
errOAAI
errMeng Yao; Jian Zhou; Jialun Mei; Chuan Gao; Peng Ding; Gan Li; Changqing Zhang; Zhiwei Li; Junjie Gao
err分享
err收藏
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology线粒体复合物III衍生的ROS放大星形胶质细胞的免疫代谢变化并促进痴呆病理
errNature Metabolism
IF20.8
err2025-11-04
err0
errOAAI
errDaniel Barnett; Till S. Zimmer; Caroline Booraem; Fernando Palaguachi; Samantha M. Meadows; Haopeng Xiao; Man Ying Wong; Wenjie Luo; Li Gan; Edward T. Chouchani; Anna G. Orr; Adam L. Orr
err分享
err收藏
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome分子伴侣介导的自噬通过性别特异性的突触蛋白质组重塑来调节神经元活动。
errNature Cell Biology
IF19.1
err2025-10-14
err0
PREAI
errRabia R. Khawaja; Ernesto Griego; Kristen Lindenau; Asma Salek; Jessica Gambardella; Aurora Scrivo; Hannah R. Monday; Mathieu Bourdenx; Jesús Madero-Pérez; Zohaib N. Khan; Bhakti Chavda; Ronald Cutler; Sarah Graff; Simone Sidoli; Gaetano Santulli; Laura Santambrogio; Inmaculada Tasset; Susmita Kaushik; Li Gan; Pablo E. Castillo; Ana Maria Cuervo
err分享
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A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain一项单细胞、长读长、异构体解析的FTD病例对照研究揭示了人类大脑中细胞类型特异性和广泛的剪接失调。
errCell Reports
IF6.9
err2025-09-05
err0
errOAAI
errNatan Belchikov; Wen Hu; Li Fan; Anoushka Joglekar; Yi He; Careen Foord; Julien Jarroux; Justine Hsu; Shaun Pollard; Sadaf Amin; Andrey D. Prjibelski; Shiaoching Gong; Sai Zhang; Roberta Giannelli; Harro Seelaar; Alexandru I. Tomescu; M. Elizabeth Ross; Alissa Nana Li; Lea T. Grinberg; Salvatore Spina; Bruce L. Miller; Johnathan Cooper-Knock; Michael P. Snyder; William W. Seeley; Priyanka Rao-Ruiz; Sabine Spijker; August B. Smit; Claire D. Clelland; Li Gan; Hagen U. Tilgner
err分享
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REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3–CD38 axisREV-ERBα通过NFIL3–CD38轴调节大脑NAD+水平并影响tauopathy。
errNature Aging
IF19.4
err2025-09-01
err0
errOAAI
errJiyeon Lee; Ryeonghwa Kang; Sohui Park; Ibrahim O. Saliu; Minsoo Son; Jaymie R. Voorhees; Julie M. Dimitry; Elsa I. Quillin; Lauren N. Woodie; Brian V. Lananna; Li Gan; Young-Ah Goo; Guoyan Zhao; Mitchell A. Lazar; Thomas P. Burris; Erik S. Musiek
err分享
err收藏
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathwayAPOE3基因中的R136S突变通过抑制cGAS-STING-IFN通路赋予对tau病理的抵抗力。
errImmunity
IF26.3
err2025-06-23
err0
PREAI
errSarah Naguib; Chloe Lopez-Lee; Eileen Ruth Torres; Se-In Lee; Jingjie Zhu; Daphne Zhu; Pearly Ye; Kendra Norman; Mingrui Zhao; Man Ying Wong; Yohannes A. Ambaw; Rodrigo Muñoz-Castañeda; Wei Wang; Tark Patel; Maitreyee Bhagwat; Rada Norinsky; Sue-Ann Mok; Tobias C. Walther; Robert V. Farese; Wenjie Luo; Subhash C. Sinha; Zhuhao Wu; Li Fan; Shiaoching Gong; Li Gan
err分享
err收藏
The impact of polyethylene microplastics exposure on the, growth performance, reproductive performance, antioxidant capacity, and intestinal microbiota of quails聚乙烯微塑料暴露对鹌鹑生长性能、繁殖性能、抗氧化能力和肠道微生物群的影响
errECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
IF6.1
err2025-05-01
err0
PREAI
errYou, Xiangbin; Zhang, Zhuo; Tian, Guijuan; Zhang, Yapei; Pei, Yanru; Wu, Yanxue; Li, Gan; Wang, Qiankun; Yang, Youbing
err分享
err收藏
Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model抑制可溶性环氧合酶水解酶可提供神经保护作用，并在tau病小鼠模型中恢复小胶质细胞的稳态。
errMOLECULAR NEURODEGENERATION
IF17.5
err2025-04-23
err0
errOAAI
errWang, Shuo; Qi, Chuangye; Rajpurohit, Chetan; Ghosh, Baijayanti; Xiong, Wen; Wang, Baiping; Qi, Yanyan; Hwang, Sung Hee; Hammock, Bruce D.; Li, Hongjie; Gan, Li; Zheng, Hui
err分享
err收藏
Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease将阿尔茨海默病中的发现科学与临床护理相结合的 emerging approaches
errNEUROTHERAPEUTICS
IF6.9
err2025-04-01
err0
errOAAI
errSinha, Subhash; Gan, Li; Pieper, Andrew A.
err分享
err收藏
Dexmedetomidine Inhibits Ferroptosis by Regulating the SRY-Box Transcription Factor 9/Divalent Metal Transporter-1 Axis to Alleviate Cerebral Ischemia/Reperfusion Injury
errCHEMICAL BIOLOGY & DRUG DESIGN
IF3.3
err2025-01-05
err0
PREAI
errLiu, Zhen; Liu, Qionghua; Zhang, Xuekang; Li, Gan
err分享
err收藏
Identification and development of cGAS inhibitors and their uses to treat Alzheimer's diseasecGAS抑制剂的鉴定与开发及其在治疗阿尔茨海默病中的应用
errNEUROTHERAPEUTICS
IF6.9
err2025-01-01
err2
errOAAI
errAlarcon-Esposito, Jazmin; Nagiri, Ravi Kumar; Gan, Li; Sinha, Subhash C.
err分享
err收藏
Mef2c Exacerbates Neuron Necroptosis via Modulating Alternative Splicing of Cflar in Ischemic Stroke With Hyperlipidemia
errCNS NEUROSCIENCE & THERAPEUTICS
IF5
err2024-12-08
err0
errOAAI
errLi, Ruqi; Huang, Tianchen; Zhou, Jianpo; Liu, Xiansheng; Li, Gan; Zhang, Yueman; Guo, Yunlu; Li, Fengshi; Li, Yan; Liesz, Arthur; Li, Peiying; Wang, Zhenghong; Wan, Jieqing
err分享
err收藏
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
errNEURON
IF15
err2024-12-01
err0
errOAAI
errCarling, Gillian K.; Fan, Li; Foxe, Nessa R.; Norman, Kendra; Wong, Man Ying; Zhu, Daphne; Corona, Carlo; Razzoli, Agnese; Yu, Fangmin; Yarahmady, Allan; Ye, Pearly; Chen, Hao; Huang, Yige; Amin, Sadaf; Sereda, Rebecca; Lopez-Lee, Chloe; Zacharioudakis, Emmanouil; Chen, Xiaoying; Xu, Jielin; Cheng, Feixiong; Gavathiotis, Evripidis; Cuervo, Ana Maria; Holtzman, David M.; Mok, Sue-Ann; Sinha, Subhash C.; Sidoli, Simone; Ratan, Rajiv R.; Luo, Wenjie; Gong, Shiaoching; Gan, Li
err分享
err收藏

研究方向

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合作学者
合作期刊
J
John Q. Trojanowski
H 指数: 255 · 论文数: 1.8K
D
Dennis W. Dickson
H 指数: 218 · 论文数: 2.3K
J
John Hardy
H 指数: 207 · 论文数: 1.9K
D
David M. Holtzman
H 指数: 204 · 论文数: 1.0K
B
Bruce L. Miller
H 指数: 201 · 论文数: 2.1K
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