James W. Janetka - Publications, H-index & Citations

James W. Janetka

washington university

36H指数

126论文数

4.8K被引数

收录论文 68

发表时间

Lead Optimization of TgCDPK1 Inhibitors for the Treatment of Toxoplasmosis 弓形虫钙调蛋白激酶1（TgCDPK1）抑制剂的临床前优化用于治疗弓形虫病

Journal of Medicinal Chemistry

IF6.8

2026-06-03

PREAI

Michael P. Mannino; Anusha Gokanapalle; Shrushti Patil; Anoopjit Singh Kooner; Chhuttan Lal Meena; Matthew Medcalf; Igi Vilza; Jennifer Barks; Yong Fu; Jing Xia; Jay C. Nix; Chris Nelson; Daved Fremont; Arun Dhillon; L. David Sibley; James W. Janetka

Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1 膜相关丝氨酸蛋白酶抑制剂可阻断冠状病毒SARS-CoV-2和流感病毒H1N1的复制

European Journal of Medicinal Chemistry

IF5.9

2025-11-20

PREAI

Victoria Banas; Kuljeet Seehra; Matthew Mahoney; Carolina Alisio; Yevhenii Kyriukha; Elizabeth Weiland; Michelle Fath; Zhenfu Han; Traci Bricker; Michael Tartell; Sean Whelan; Adrianus C.M. Boon; James W. Janetka

Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections 源自激酶抑制剂SGI-1776的抗蠕虫药，用于治疗肠道蠕虫感染

ACS Infectious Diseases

IF3.8

2025-10-14

PREAI

Mostafa A. Elfawal; Victoria Banas; Bruce A. Rosa; Matthew Mahoney; Emily Goetz; Paulina Chen; Raffi V. Aroian; James W. Janetka; Makedonka Mitreva

Recent advances in the development of promising carbohydrate-based therapeutics 近年来在开发有前景的碳水化合物基疗法方面的最新进展

Expert Opinion on Drug Discovery

IF4.9

2025-08-21

PREAI

Nayyar Ahmad Aslam; Yevhenii Kyriukha; James W. Janetka

Structure-Based Drug Design of Novel Heterocyclic Scaffolds as TgCDPK1 Inhibitors 基于结构的药物设计：新型杂环骨架作为TgCDPK1抑制剂的研发

ChemMedChem

IF3.4

2025-08-08

PREAI

Anoopjit Singh Kooner; Mariah Norman; Igi Vilza; Michael P. Mannino; Mary Savari Dhason; Jon Helander; Shrushti Patil; L. David Sibley; James W. Janetka

Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections

ACS INFECTIOUS DISEASES

IF3.8

2025-01-20

PREAI

Banas, Victoria; Elfawal, Mostafa A.; Rosa, Bruce A.; Mahoney, Matthew; Kauffman, Jacquelyn; Goetz, Emily; Chen, Paulina; Aroian, Raffi V.; Mitreva, Makedonka; Janetka, James W.

Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19

JOURNAL OF VIROLOGY

IF3.8

2024-05-14

OAAI

Boon, Adrianus C. M.; Bricker, Traci L.; Fritch, Ethan J.; Leist, Sarah R.; Gully, Kendra; Baric, Ralph S.; Graham, Rachel L.; Troan, Brigid V.; Mahoney, Matthew; Janetka, James W.

Autocrine HGF maturation as a targetable regulatory step in cetuximab resistance in colorectal cancer

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Jones, Vivian Truong; Graves-Deal, Ramona; Cao, Zheng; Bogatcheva, Galina; Ramirez, Marisol A.; Harmych, Sarah J.; Higginbotham, James N.; Wahoski, Claudia C.; Joshi, Neeraj; Roland, Joseph T.; Ayers, Gregory D.; Liu, Qi; Coffey, Robert J.; Janetka, James W.; Singh, Bhuminder

Mechanism-Based Macrocyclic Inhibitors of Serine Proteases

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-03-13

PREAI

Damalanka, Vishnu C.; Banas, Victoria; De Bona, Paolo; Kashipathy, Maithri M.; Battaile, Kevin; Lovell, Scott; Janetka, James W.

Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction

CHEMMEDCHEM

IF3.4

2024-03-05

PREAI

Obermann, Robert; Yemane, Bereket; Jarvis, Cassie; Franco, Francisco M.; Kyriukha, Yevhenii; Nolan, William; Gohara, Beth; Krezel, Andrzej M.; Wildman, Scott A.; Janetka, James W.

Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-02-03

PREAI

Maddirala, Amarendar Reddy; Pinkner, Jerome S.; Tamadonfar, Kevin; Sanick, Denise; Hultgren, Scott J.; Janetka, James W.

Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer 抑制自分泌HGF成熟可克服结直肠癌的西妥昔单抗耐药性

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2024-01-12

OAAI

Jones, Vivian Truong; Graves-Deal, Ramona; Cao, Zheng; Bogatcheva, Galina; Ramirez, Marisol A.; Harmych, Sarah J.; Higginbotham, James N.; Sharma, Vineeta; Damalanka, Vishnu C.; Wahoski, Claudia C.; Joshi, Neeraj; Irudayam, Maria Johnson; Roland, Joseph T.; Ayers, Gregory D.; Liu, Qi; Coffey, Robert J.; Janetka, James W.; Singh, Bhuminder

Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis

MOLECULAR ONCOLOGY

IF4.5

2023-11-13

OAAI

Belitskin, Denis; Munne, Pauliina; Pant, Shishir M.; Anttila, Johanna M.; Suleymanova, Ilida; Belitskina, Kati; Kirchhofer, Daniel; Janetka, James; Kasper, Taivo; Jalil, Sami; Pouwels, Jeroen; Tervonen, Topi A.; Klefstrom, Juha

HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis HGF/c-met通路抑制联合化疗增加细胞毒性T细胞浸润并抑制胰腺肿瘤生长和转移

CANCER LETTERS

IF10.1

2023-08-01

OAAI

Mekapogu, Alpha Raj; Xu, Zhihong; Pothula, Srinivasa; Perera, Chamini; Pang, Tony; Hosen, S. M. Zahid; Damalanka, Vishnu; Janetka, James; Goldstein, David; Pirola, Romano; Wilson, Jeremy; Apte, Minoti

Overcoming Cetuximab Resistance in Colorectal Cancer through Inhibition of HGF Processing

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-06-01

OAAI

Jones, Vivian; Graves-Deal, Ramona; Bogatcheva, Galina; Cao, Zheng; Higginbotham, James; Harmych, Sarah; Ramirez, Marisol; Liu, Qi; Ayers, Gregory; Janetka, James; Singh, Bhuminder

Role of MET signaling in cetuximab resistance and generation of an imaging biomarker to identify MET-driven cetuximab resistance in colorectal cancer

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Jones, Vivian T.; Graves-Deal, Ramona; Jeon, Kyuok; Rosenberg, Adam J.; Cao, Zheng; Bogatcheva, Galina T.; Harmych, Sarah J.; Higginbotham, James N.; Kim, Kwangho; Janetka, James W.; Sulikowski, Gary A.; Singh, Bhuminder

eOvercoming cetuximab resistance in colorectal cancer through inhibition of HGF processing

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Jones, Vivian Truong; Graves-Deal, Ramona; Bogatcheva, Galina; Cao, Zheng; Higginbotham, James; Harmych, Sarah; Ayers, Gregory; Ramirez, Marisol; Liu, Qi; Janetka, James; Singh, Bhuminder

Aspartyl Protease Inhibitors as Anti-Filarial Drugs 天冬氨酰蛋白酶抑制剂作为抗丝虫药物

PATHOGENS

IF3.3

2022-06-18

OAAI

Beld, Liana; Jung, Hyeim; Bulman, Christina A.; Rosa, Bruce A.; Fischer, Peter U.; Janetka, James W.; Lustigman, Sara; Sakanari, Judy A.; Mitreva, Makedonka

Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-12-13

OAAI

Damalanka, Vishnu C.; Voss, Jorine J. L. P.; Mahoney, Matthew W.; Primeau, Tina; Li, Shunqiang; Klampfer, Lidija; Janetka, James W.

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-10-11

OAAI

Mahoney, Matthew; Damalanka, Vishnu C.; Tartell, Michael A.; Chung, Dong Hee; Lourenco, Andre Luiz; Pwee, Dustin; Bridwell, Anne E. Mayer; Hoffmann, Markus; Voss, Jorine; Karmakar, Partha; Azouz, Nurit P.; Klingler, Andrea M.; Rothlauf, Paul W.; Thompson, Cassandra E.; Lee, Melody; Klampfer, Lidija; Stallings, Christina L.; Rothenberg, Marc E.; Pohlmann, Stefan; Whelan, Sean P. J.; O'Donoghue, Anthony J.; Craik, Charles S.; Janetka, James W.

研究方向