Gregory M. Cook - Publications, H-index & Citations

Gregory M. Cook

University of Otago

64H指数

386论文数

1.4W被引数

收录论文 170

发表时间

Development of Thieno[2,3-b]pyridin-6(7H)-one derivatives against drug-resistant Mycobacterium tuberculosis 开发针对耐药分枝杆菌的噻吩并[2,3-b]吡啶-6(7H)-酮衍生物

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2026-04-11

PREAI

Qin Zha; Zhiyong Liu; Wanwen Li; Yihuan Zhou; Matthew B. McNeil; Gregory M. Cook; Tianyu Zhang; Niuniu Zhang

ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis ClpC1-targeting肽天然产物差异调节结核分枝杆菌蛋白质组

Nature Communications

IF15.7

2026-01-29

OAAI

Isabel K. Barter; Max J. Bedding; Julia Leodolter; Joshua W. C. Maxwell; Paige M. E. Hawkins; Maxwell T. Stevens; Matthew B. McNeil; William J. Jowsey; Trixie Wang; Diana Quan; Sabryna Junker; Manuela Flórido; Daniel Hesselson; Gregory M. Cook; Tim Clausen; Warwick J. Britton; Mark Larance; Richard J. Payne

Design; synthesis and biological activity of potential retrometabolic polymyxins via thiol–ene chemistry 设计；通过硫醇-烯化学合成并研究潜在后代谢多粘菌素的生物活性

Chem. Commun.

IF0

2025-12-04

PREAI

Catherine Smith; Andrew Siow; Renata Kowalczyk; Scott A. Ferguson; Matigan J. B. Smith; Gregory M. Cook; Veronika Sander; Alan J. Davidson; Margaret A. Brimble; Paul W. R. Harris

Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria 发射光谱法解析了bedaquiline在活分枝杆菌中的作用机制

Nature Communications

IF15.7

2025-11-25

OAAI

Suzanna H. Harrison; Rowan C. Walters; Chen-Yi Cheung; Roger J. Springett; Gregory M. Cook; Morwan M. Osman; James N. Blaza

Advancing the antituberculosis activity of nitropicolinic acids and amides 推进硝基吡嗪甲酸及其酰胺的抗结核活性

European Journal of Medicinal Chemistry

IF5.9

2025-10-29

OAAI

Andrew M. Thompson; Chen-Yi Cheung; Matthew B. McNeil; Ashley C. Campbell; Monika Záhorszká; Jana Korduláková; Giovanni Stelitano; Deborah Recchia; Maria Rosalia Pasca; Baojie Wan; Shahebraj Khan; Dejan S. Nikolic; Gauri S. Shetye; Scott G. Franzblau; William A. Denny; Gregory M. Cook; Kurt L. Krause

ClpC1 Modulating Ohmyungsamycin A and Ecumicin Natural Product Analogues are Potent Antimycobacterials ClpC1调控的Ohmyungsamycin A和Ecumicin天然产物类似物是强效抗分枝杆菌药物。

ACS Infectious Diseases

IF3.8

2025-10-23

PREAI

Paige M. E. Hawkins; Max J. Bedding; David M. Hoi; Isabel K. Barter; Chen-Yi Cheung; Stefan H. Oehlers; Gregory M. Cook; Tim Clausen; Warwick J. Britton; Richard J. Payne

Beyond the 2+2 Pharmacophore Electronic and Hydrophobic Effects Control the Activity of Cationic Amphiphilic Antimicrobial 2,5-Diketopiperazines 除了2 2药效团之外，电子和疏水作用还控制阳离子两亲性抗菌剂2，5-二酮哌嗪的活性

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-10-01

PREAI

Siu, Christy; Siew, Tashia; Li, Freda F.; Mros, Sonya; Cleary, Caitlin S. B.; Ferguson, Scott A.; Cook, Gregory M.; Cahill, Patrick; Brimble, Margaret A.; Svenson, Johan; Rennison, David

Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand 新西兰地方性金黄色葡萄球菌ST1的基因组比较研究

MSPHERE

IF3.1

2025-09-01

PREAI

Voss, Emma M.; Cook, Gregory M.; Couldrey, Christine; Ferguson, Scott A.; Harland, Chad; Karkaba, Ali; Mcdougall, Scott; Morales, Sergio E.; Rolfe, Jack; Ussher, James E.; White, Rhys T.; Williams, Liam; Williamson, John

Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia 全基因组测序揭示了来自印度尼西亚的耐药分枝杆菌菌株中的新型耐药相关突变和大片段基因组缺失。

Journal of Global Antimicrobial Resistance

IF3.2

2025-07-22

OAAI

Htin Lin Aung; Lidya Chaidir; Dian Ayu Eka Pitaloka; Yugen Miyahara; Narender Kumar; Arto Yuwono Soeroto; Greg M Cook; Reinout van Crevel; Bachti Alisjahbana; Sharon J. Peacock; Philip C Hill

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity 维拉帕米及其代谢物去甲维拉帕米通过抑制结核分枝杆菌MmpS5L5外排泵来增强贝达喹啉的活性。

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2025-04-17

OAAI

Fountain, Adam J.; Waller, Natalie J. E.; Cheung, Chen - Yi; Jowsey, William; Chrisp, Michael T.; Troll, Mark; Edelstein, Paul H.; Cook, Gregory M.; Ramakrishnan, Lalita

Structure of Mycobacterial NDH-2 Bound to a 2-Mercapto-Quinazolinone Inhibitor 分枝杆菌NDH-2与2-巯基-喹唑啉酮抑制剂的复合物结构

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-03-21

OAAI

Liang, Yingke; Bueler, Stephanie A.; Cook, Gregory M.; Rubinstein, John L.

Development of tolerance to bedaquiline by overexpression of trypanosomal acetate: succinate CoA transferase in Mycobacterium smegmatis

COMMUNICATIONS BIOLOGY

IF5.1

2025-02-06

OAAI

Bundutidi, Gloria Mavinga; Mochizuki, Kota; Matsuo, Yuichi; Hayashishita, Mizuki; Sakura, Takaya; Ando, Yuri; Cook, Gregory Murray; Rajib, Acharjee; Bringaud, Frederic; Boshart, Michael; Hamano, Shinjiro; Sekijima, Masakazu; Hirayama, Kenji; Kita, Kiyoshi; Inaoka, Daniel Ken

A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis 一种新型非侵入性小鼠模型，用于通过吸入给药快速测试抗分枝杆菌结核分枝杆菌的药物活性

FRONTIERS IN PHARMACOLOGY

IF4.8

2025-01-03

OAAI

Tian, Xirong; Gao, Yamin; Li, Chunyu; Ma, Wanli; Zhang, Jingran; Ju, Yanan; Ding, Jie; Zeng, Sanshan; Hameed, H. M. Adnan; Aung, Htin Lin; Zhong, Nanshan; Cook, Gregory M.; Hu, Jinxing

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis 全基因组CRISPRi筛选鉴定了耐异烟肼结核分枝杆菌菌株的可药物靶点脆弱性

NATURE COMMUNICATIONS

IF15.7

2024-11-13

OAAI

Wang, Xinyue; Jowsey, William J.; Cheung, Chen-Yi; Smart, Caitlan J.; Klaus, Hannah R.; Seeto, Noon E. J.; Waller, Natalie J. E.; Chrisp, Michael T.; Peterson, Amanda L.; Ofori-Anyinam, Boatema; Strong, Emily; Nijagal, Brunda; West, Nicholas P.; Yang, Jason H.; Fineran, Peter C.; Cook, Gregory M.; Jackson, Simon A.; McNeil, Matthew B.

Phenotypic-Based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium tuberculosis

CHEMMEDCHEM

IF3.4

2024-10-25

OAAI

Tran, Eric; Cheung, Chen-Yi; Li, Lucy; Carter, Glen P.; Gable, Robert W.; West, Nicholas P.; Kaur, Amandeep; Gee, Yi Sing; Cook, Gregory M.; Baell, Jonathan B.; Joerg, Manuela

Identification of Chemical Scaffolds That Inhibit the Mycobacterium tuberculosis Respiratory Complex Succinate Dehydrogenase 抑制结核分枝杆菌呼吸复合琥珀酸脱氢酶的化学支架的鉴定

ACS INFECTIOUS DISEASES

IF3.8

2024-09-13

PREAI

Adolph, Cara; Hards, Kiel; Williams, Zoe C.; Cheung, Chen-Yi; Keighley, Laura M.; Jowsey, William J.; Kyte, Matson; Inaoka, Daniel Ken; Kita, Kiyoshi; Mackenzie, Jared S.; Steyn, Adrie J. C.; Li, Zhengqiu; Yan, Ming; Tian, Guo-Bao; Zhang, Tianyu; Ding, Xiaobo; Furkert, Daniel P.; Brimble, Margaret A.; Hickey, Anthony J. R.; McNeil, Matthew B.; Cook, Gregory M.

Remission cytochrome spectroscopy reveals the mode of action of bedaquiline in living mycobacteria

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

IF2.7

2024-09-01

PREAI

Harrison, Suzanna H.; Walters, Rowan C.; Osman, Morwan M.; Springett, Roger J.; Cook, Gregory M.; Blaza, James N.

Discovery of dual-targeting bioenergetic inhibitors to produce fast-acting antimicrobials for the rapid treatment of tuberculosis disease

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

IF2.7

2024-09-01

PREAI

Cook, Gregory Murray

Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus 海洋海绵微生物为结核杆菌的进化和毒力提供了见解

PLOS PATHOGENS

IF4.9

2024-08-29

OAAI

Pidot, Sacha J.; Klatt, Stephan; Ates, Louis S.; Frigui, Wafa; Sayes, Fadel; Majlessi, Laleh; Izumi, Hiroshi; Monk, Ian R.; Porter, Jessica L.; Bennett-Wood, Vicki; Seemann, Torsten; Otter, Ashley; Taiaroa, George; Cook, Gregory M.; West, Nicholas; Tobias, Nicholas J.; Fuerst, John A.; Stutz, Michael D.; Pellegrini, Marc; McConville, Malcolm; Brosch, Roland; Stinear, Timothy P.

Allenamides as a Powerful Tool to Incorporate Diversity: Thia-Michael Lipidation of Semisynthetic Peptides and Access to β-Keto Amides

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2024-08-22

OAAI

Na, Tae-Ung; Sander, Veronika; Davidson, Alan J.; Lin, Rolland; Hermant, Yann O.; Hardie Boys, Madeleine T.; Pletzer, Daniel; Campbell, Georgia; Ferguson, Scott A.; Cook, Gregory M.; Allison, Jane R.; Brimble, Margaret A.; Northrop, Brian H.; Cameron, Alan J.

研究方向