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孔

孔祥谦 (Xiangqian Kong)

university of science and technology of china

29H指数
115论文数
3.2K被引数
收录论文 44
发表时间
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Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition降低的维持DNA甲基化阈值使UHRF1和DNMT1抑制的敏感报告基因分析成为可能
errAdvanced Science
IF14.1
err2026-03-26
err0
errOAAI
errCuicui Xia; Ying Cui; Jiongliang Wang; Wenjing Bai; Danyang Wang; Yao Chen; Huahui Guo; Liangyi Zong; Bing Qin; Xintong Cai; Jie Wang; Jing Huang; Scott B. Rothbart; Zufeng Guo; Stephen B. Baylin; Xiangqian Kong
err分享
err收藏
High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay利用细胞蛋白稳定性增强测定法进行活细胞中的高通量配体发现
errActa Pharmaceutica Sinica B
IF14.6
err2026-02-10
err0
errOAAI
errYue Wei; Yunyun Gao; Ruijie Li; Yao Chen; Wenjing Bai; Peirui Zhao; Junchi Hu; Linfeng Li; Xing Wang; Guobing Yin; Yongjun Dang; Xiangqian Kong; Zufeng Guo
err分享
err收藏
Mapping Context-Aware Phosphosite Regulation of Protein–Protein Interactions Using Deep Learning and Pan-Cancer Proteomics使用深度学习和泛癌蛋白质组学映射情境感知的磷酸化位点对蛋白质-蛋白质相互作用的调控
errJournal of Chemical Information and Modeling
IF5.3
err2025-10-10
err0
PREAI
errMingyue Cai; Yuqing Xiao; Jiani Zheng; Jincheng Shi; Jieying Wu; Xiangqian Kong; Zhongjie Liang
err分享
err收藏
C-14 oxygenated quassinoids with control effect against larvae of Diaphorina citri Kuwayama from fruits of Picrasma quassioidesC-14 氧化苦木素类化合物，其对桔小实蝇（Diaphorina citri Kuwayama）幼虫具有控制效果，来源于苦木科苦树（Picrasma quassioides）的果实。
errPest Management Science
IF3.8
err2025-08-15
err0
PREAI
errLi-Ming Zhan; Ting-Mi Yang; Yang Han; Fei Liu; Ting Liu; Wen-Jing Bai; Xiang-Qian Kong; Li-Jun Zhang; Hai-Bing Liao
err分享
err收藏
Acylated Iridoid glycosides with neuroprotective and α-glucosidase inhibitory activities from Buddleja lindleyana fort.阿酰化环烯醚萜苷（具有神经保护和α-葡萄糖苷酶抑制活性，来源于Buddleja lindleyana fort.）
errBIOORGANIC CHEMISTRY
IF4.7
err2025-06-01
err0
PREAI
errZhan, Li-Ming; Zhou, Ze Chang; Wang, Rong; Wang, Min; Song, Jia-Qi; Liu, Ting; Bai, Wen-Jing; Kong, Xiang-Qian; Liao, Hai-Bing; Zhang, Li-Jun
err分享
err收藏
Steroids with prominent cytotoxic activity against non-small cell lung cancer cells from the Strophanthus divaricatusStrophanthus divaricatus中具有显著细胞毒活性的对非小细胞肺癌细胞的类固醇
errFITOTERAPIA
IF2.6
err2025-04-01
err0
PREAI
errZhu, Yu-Hui; Chen, Wen; Song, Jia-Qi; Bai, Wen-Jing; Zhan, Li-Ming; Liu, Ting; Huang, Ya-Si; Zhang, Li-Jun; Kong, Xiang-Qian; Liao, Hai-Bing
err分享
err收藏
UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-11-28
err0
errOAAI
errTiedemann, Rochelle L.; Hrit, Joel; Du, Qian; Wiseman, Ashley K.; Eden, Hope E.; Dickson, Bradley M.; Kong, Xiangqian; Chomiak, Alison A.; Vaughan, Robert M.; Tibben, Bailey M.; Hebert, Jakob M.; David, Yael; Zhou, Wanding; Baylin, Stephen B.; Jones, Peter A.; Clark, Susan J.; Rothbart, Scott B.
err分享
err收藏
Discovery of KW0113 as a First and Effective PROTAC Degrader of DNMT1 Protein
errCHEMMEDCHEM
IF3.4
err2024-11-07
err0
PREAI
errWang, Huihui; Wang, Zhaoliang; Hu, Linghao; Yang, Bingjie; Zong, Liangyi; Xu, Dounan; Yu, Bo; Kong, Xiangqian; Wang, Mingliang
err分享
err收藏
Efficient Public-Key Searchable Encryption Scheme From PSI With Scalable Proxy Servers
errIEEE TRANSACTIONS ON SERVICES COMPUTING
IF5.8
err2024-11-01
err1
PREAI
errKong, Xiangqian; Chen, Lanxiang; Zhu, Yizhao; Mu, Yi
err分享
err收藏
Development of a First-in-Class DNMT1/HDAC Inhibitor with Improved Therapeutic Potential and Potentiated Antitumor Immunity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-12
err1
PREAI
errChang, Yingjie; Guo, Huahui; Li, Xue; Zong, Liangyi; Wei, Jiale; Li, Zhihai; Luo, Cheng; Yang, Xinying; Fang, Hao; Kong, Xiangqian; Hou, Xuben
err分享
err收藏
Picrachinentins A-F, 14-Membered Cyclopeptide Alkaloid-Type Burpitides with Uncommon N-Terminal Modifications from Picrasma chinensis and Their Neuroprotective Activity
errORGANIC LETTERS
IF5
err2024-05-24
err2
PREAI
errFan, Xian-zhe; Song, Jia-qi; Zhang, Li-jun; Wang, Rong; Liu, Ting; Bai, Wen-jing; Kong, Xiang-qian; Huang, Ya-si; Liang, Hong; Liao, Hai-bing
err分享
err收藏
Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling选择EZH2抑制剂通过涉及NFAT的机制增强DNMT抑制的病毒模仿效应: AP-1信号
errSCIENCE ADVANCES
IF12.5
err2024-03-29
err3
errOAAI
errChomiak, Alison A.; Tiedemann, Rochelle L.; Liu, Yanqing; Kong, Xiangqian; Cui, Ying; Wiseman, Ashley K.; Thurlow, Kate E.; Cornett, Evan M.; Topper, Michael J.; Baylin, Stephen B.; Rothbart, Scott B.
err分享
err收藏
Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase
errACS CHEMICAL BIOLOGY
IF3.8
err2024-03-21
err2
PREAI
errZhang, Huimin; Xu, Dounan; Huang, Hongchan; Jiang, Hao; Hu, Linghao; Liu, Liping; Sun, Ge; Gao, Jing; Li, Yuanqing; Xia, Cuicui; Chen, Shijie; Zhou, Hu; Kong, Xiangqian; Wang, Mingliang; Luo, Cheng
err分享
err收藏
PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma
errCANCER RESEARCH
IF16.6
err2023-11-22
err5
PREAI
errTao, Hongru; Jin, Chen; Zhou, Liyuan; Deng, Zhenzhong; Li, Xiao; Dang, Wenzhen; Fan, Shijie; Li, Bing; Ye, Fei; Lu, Junyan; Kong, Xiangqian; Liu, Chuanpeng; Luo, Cheng; Zhang, Yuanyuan
err分享
err收藏
Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties
errJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
IF5.4
err2022-06-07
err6
errOAAI
errLi, Ennian; Wang, Kai; Zhang, Bei; Guo, Siqi; Xiao, Senhao; Pan, Qi; Wang, Xiaowan; Chen, Weiying; Wu, Yunshan; Xu, Hesong; Kong, Xiangqian; Luo, Cheng; Chen, Shijie; Liu, Bo
err分享
err收藏
Terpenoids with α-glucosidase inhibitory activity from Rhododendron minutiflorum Hu
errPHYTOCHEMISTRY
IF3.4
err2022-04-01
err11
PREAI
errFan, Xian-Zhe; Zhu, Yang-Li; Yuan, Rong-Wen; Deng, Li; Hou, Cheng; Li, Wei; Liu, Ting; Kong, Xiang-Qian; Zhang, Li-Jun; Liao, Hai-Bing
err分享
err收藏
Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-12-28
err28
PREAI
errXiang, Qiuping; Wang, Chao; Wu, Tianbang; Zhang, Cheng; Hu, Qingqing; Luo, Guolong; Hu, Jiankang; Zhuang, Xiaoxi; Zou, Lingjiao; Shen, Hui; Wu, Xishan; Zhang, Yan; Kong, Xiangqian; Liu, Jinsong; Xu, Yong
err分享
err收藏
A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones
errnon coding rna research
IF3
err2021-12-16
err4
errOAAI
errLiu, Wei; Wang, Yuyan; Huang, Hongchan; Fackche, Nadege; Rodgers, Kristen; Lee, Beverly; Nizam, Wasay; Khan, Hamza; Lu, Zhihao; Kong, Xiangqian; Li, Yanfei; Liang, Naixin; Zhao, Xin; Jin, Xin; Liu, Haibo; Talbot, Charles Conover, Jr.; Huang, Peng; Eshleman, James R.; Lai, Qi; Zhang, Yi; Brock, Malcolm, V; Mei, Yuping
err分享
err收藏
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-06-02
err26
PREAI
errDu, Daohai; Xu, Dandan; Zhu, Licheng; Stazi, Giulia; Zwergel, Clemens; Liu, Yanli; Luo, Zhongyuan; Li, Yuanqing; Zhang, Yuanyuan; Zhu, Kongkai; Ding, Yiluan; Liu, Jingqiu; Fan, Shijie; Zhao, Kaiyan; Zhang, Naixia; Kong, Xiangqian; Jiang, Hualiang; Chen, Kaixian; Zhao, Kehao; Valente, Sergio; Min, Jinrong; Duan, Wenhu; Luo, Cheng
err分享
err收藏
IFI16 contributes to the pathogenesis of abdominal aortic aneurysm by regulating the caspase-1/IL-1β/MCPIP1 pathway
errLIFE SCIENCES
IF5.1
err2021-01-01
err12
PREAI
errXue, Ming; Li, Dan; Wang, Zhu; Mi, Lei; Cao, Shuwei; Zhang, Lijun; Kong, Xiangqian
err分享
err收藏

研究方向

肿瘤表观遗传学和药物精准应用肿瘤转录异常的分子机制和创新药物发现
合作学者
合作期刊
S
Stephen B. Baylin
H 指数: 182 · 论文数: 1.3K
Chuan He 封面图
Chuan He (Chuan He)
H 指数: 161 · 论文数: 981
M
Michael Diamond
H 指数: 160 · 论文数: 1.5K
P
Peter A. Jones
H 指数: 130 · 论文数: 754
刘海波 封面图
刘海波 (Haibo Liu)
H 指数: 129 · 论文数: 3.7K
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