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Simultaneous Grafting of 3,4,5-Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors 通过双重还原胺化将3,4,5-三羟基哌啶类含氮糖连接到多价支架上，可提供新的GCase抑制剂 Davighi, Maria Giulia; Clemente, Francesca; Morano, Alessio; Mangiavacchi, Francesca; Cardona, Francesca; Goti, Andrea; Paoli, Paolo; Morrone, Amelia; Nieto-fabregat, Ferran; Marchetti, Roberta; Matassini, Camilla 分享 收藏
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A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties (vol 275, 116567, 2024) Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio 分享 收藏
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Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia Pranzini, Erica; Muccillo, Livio; Nesi, Ilaria; Santi, Alice; Mancini, Caterina; Lori, Giulia; Genovese, Massimo; Lottini, Tiziano; Comito, Giuseppina; Caselli, Anna; Arcangeli, Annarosa; Sabatino, Lina; Colantuoni, Vittorio; Taddei, Maria Letizia; Cirri, Paolo; Paoli, Paolo 分享 收藏
A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio 分享 收藏
Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer Nesi, Ilaria; Della Bella, Chiara; Taddei, Maria Letizia; Santi, Alice; Pranzini, Erica; Paoli, Paolo; D'Elios, Mario Milco; Ramazzotti, Matteo; Genovese, Massimo; Caselli, Anna; Cirri, Paolo 分享 收藏
Rumen microbial community and milk quality in Holstein lactating cows fed olive oil pomace as part in a sustainable feeding strategy 饲喂橄榄油渣的荷斯坦泌乳奶牛的瘤胃微生物群落和牛奶质量是可持续饲喂策略的一部分 Scicutella, F.; Cucu, M. A.; Mannelli, F.; Pastorelli, R.; Daghio, M.; Paoli, P.; Pazzagli, L.; Turini, L.; Mantino, A.; Luti, S.; Genovese, M.; Viti, C.; Buccioni, A. 分享 收藏
Designed multiple ligands for the treatment of type 2 diabetes mellitus and its complications: Discovery of (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl) alkanoic acids active as novel dual-targeted PTP1B/AKR1B1 inhibitors 设计用于治疗2型糖尿病及其并发症的多种配体: 发现具有新型双靶向PTP1B/AKR1B1抑制剂活性的 (5-arylidene-4-oxo-2-thioxothiazolidin-3-yl) 链烷酸 Maccari, Rosanna; Wolber, Gerhard; Genovese, Massimo; Sardelli, Gemma; Talagayev, Valerij; Balestri, Francesco; Luti, Simone; Santi, Alice; Moschini, Roberta; Del Corso, Antonella; Paoli, Paolo; Ottana, Rosaria 分享 收藏
Light-Triggered Control of Glucocerebrosidase Inhibitors: Towards Photoswitchable Pharmacological Chaperones Clemente, Francesca; Davighi, Maria Giulia; Matassini, Camilla; Cardona, Francesca; Goti, Andrea; Morrone, Amelia; Paoli, Paolo; Tejero, Tomas; Merino, Pedro; Cacciarini, Martina 分享 收藏
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Ca, Sudeep; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio 分享 收藏
Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara Casertano, Marcello; Genovese, Massimo; Santi, Alice; Pranzini, Erica; Balestri, Francesco; Piazza, Lucia; Del Corso, Antonella; Avunduk, Sibel; Imperatore, Concetta; Menna, Marialuisa; Paoli, Paolo 分享 收藏
Studying the trafficking of labeled trodusquemine and its application as nerve marker for light-sheet and expansion microscopy Capitini, Claudia; Pesce, Luca; Fani, Giulia; Mazzamuto, Giacomo; Genovese, Massimo; Franceschini, Alessandra; Paoli, Paolo; Pieraccini, Giuseppe; Zasloff, Michael; Chiti, Fabrizio; Pavone, Francesco S.; Calamai, Martino 分享 收藏
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A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity 对过氧化物酶体增殖物激活受体配体的化学信息学搜索揭示了一种新的泛激动剂，能够减少脂质积累并改善胰岛素敏感性 Sblano, Sabina; Cerchia, Carmen; Laghezza, Antonio; Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba; Gilardi, Federica; Thomas, Aurelien; Genovese, Massimo; Santi, Alice; Tortorella, Paolo; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio 分享 收藏
Identifying Human PTP1B Enzyme Inhibitors from Marine Natural Products: Perspectives for Developing of Novel Insulin-Mimetic Drugs Casertano, Marcello; Genovese, Massimo; Piazza, Lucia; Balestri, Francesco; Del Corso, Antonella; Vito, Alessio; Paoli, Paolo; Santi, Alice; Imperatore, Concetta; Menna, Marialuisa 分享 收藏
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