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Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform 使用集成药物发现平台鉴定PPM1D小分子抑制剂 Shaw, Subrata; Jiang, Wei; Rush, Jason; Dumont, Nancy; Kim, John; Singh, Ritu; Skepner, Adam; Khodier, Carol; Raffier, Cerise; Murphy, Zachary; Yan, Ni; Schluter, Cameron; Yu, Xiao; Szuchnicki, Mateusz; Sathappa, Murugappan; Kahn, Josephine; Sperling, Adam S.; Wagner, Florence; Mckinney, David C.; Gould, Alexandra E.; Garvie, Colin W.; Miller, Peter G. 分享 收藏
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations 用匹配的化学和遗传扰动处理的细胞的300万张图像和形态特征 Chandrasekaran, Srinivas Niranj; Cimini, Beth A.; Goodale, Amy; Miller, Lisa; Kost-Alimova, Maria; Jamali, Nasim; Doench, John G.; Fritchman, Briana; Skepner, Adam; Melanson, Michelle; Kalinin, Alexandr A.; Arevalo, John; Haghighi, Marzieh; Caicedo, Juan C.; Kuhn, Daniel; Hernandez, Desiree; Berstler, James; Shafqat-Abbasi, Hamdah; Root, David E.; Swalley, Susanne E.; Garg, Sakshi; Singh, Shantanu; Carpenter, Anne E. 分享 收藏
Optimizing the Cell Painting assay for image-based profiling 优化基于图像的分析的细胞绘画分析 Cimini, Beth A.; Chandrasekaran, Srinivas Niranj; Kost-Alimova, Maria; Miller, Lisa; Goodale, Amy; Fritchman, Briana; Byrne, Patrick; Garg, Sakshi; Jamali, Nasim; Logan, David J.; Concannon, John B.; Lardeau, Charles-Hugues; Mouchet, Elizabeth; Singh, Shantanu; Abbasi, Hamdah Shafqat; Aspesi, Jr Peter; Boyd, Justin D.; Gilbert, Tamara; Gnutt, David; Hariharan, Santosh; Hernandez, Desiree; Hormel, Gisela; Juhani, Karolina; Melanson, Michelle; Mervin, Lewis H.; Monteverde, Tiziana; Pilling, James E.; Skepner, Adam; Swalley, Susanne E.; Vrcic, Anita; Weisbart, Erin; Williams, Guy; Yu, Shan; Zapiec, Bolek; Carpenter, Anne E. 分享 收藏
Molecular basis for substrate recruitment to the PRMT5 methylosome Mulvaney, Kathleen M.; Blomquist, Christa; Acharya, Nischal; Li, Ruitong; Ranaghan, Matthew J.; O'Keefe, Meghan; Rodriguez, Diego J.; Young, Michael J.; Kesar, Devishi; Pal, Debjani; Stokes, Matthew; Nelson, Alissa J.; Jain, Sidharth S.; Yang, Annan; Mullin-Bernstein, Zachary; Columbus, Josie; Bozal, Fazli K.; Skepner, Adam; Raymond, Donald; LaRussa, Salvatore; McKinney, David C.; Freyzon, Yelena; Baidi, Yossef; Porter, Dale; Aguirre, Andrew J.; Ianari, Alessandra; McMillan, Brian; Sellers, William R. 分享 收藏
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Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction McKinney, David C.; McMillan, Brian J.; Ranaghan, Matthew; Moroco, Jamie A.; Brousseau, Merissa; Mullin-Bernstein, Zachary; O'Keefe, Meghan; McCarren, Patrick; Mesleh, Michael F.; Mulvaney, Kathleen M.; Robinson, Foxy; Singh, Ritu; Bajrami, Besnik; Wagner, Florence F.; Hilgraf, Robert; Drysdale, Martin J.; Campbell, Arthur J.; Skepner, Adam; Timm, David E.; Porter, Dale; Kaushik, Virendar K.; Sellers, William R.; Ianari, Alessandra 分享 收藏
High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding Chiang, Wei-Chung; Wei, Yongjie; Kuo, Yi-Chun; Wei, Shuguang; Zhou, Anwu; Zou, Zhongju; Yehl, Jenna; Ranaghan, Matthew J.; Skepner, Adam; Bittker, Joshua A.; Perez, Jose R.; Posner, Bruce A.; Levine, Beth 分享 收藏
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment Weiwer, Michel; Xu, Qihong; Gale, Jennifer P.; Lewis, Michael; Campbell, Arthur J.; Schroeder, Frederick A.; van de Bittner, Genevieve C.; Walk, Michelle; Amaya, Aldo; Su, Ping; Dordevic, Luka; Sacher, Joshua R.; Skepner, Adam; Fei, David; Dennehy, Kelly; Nguyen, Shannon; Faloon, Patrick W.; Perez, Jose; Cottrell, Jeffrey R.; Liu, Fang; Palmer, Michelle; Pan, Jen Q.; Hooker, Jacob M.; Zhang, Yan-Ling; Scolnick, Edward; Wagner, Florence F.; Holson, Edward B. 分享 收藏
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