logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
arrow
J

John G. Doench

broad institute of mit and harvard
H指数:80
被引数:4.3万

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

转录生物传感器揭示了α-酮戊二酸向染色质的信号传导机制

Science
IF45.8
2026-07-160
PRE
Alex C. Sternisha; Haocheng Li; Kumar Gajendra; Yi Xiao; Xin Zhao; Jeffrey I. Traylor; Lei Guo; Ji Hyung Jun; Morgan Fleishman; Tracey Shipman; Vinesh T. Puliyappadamba; Pranita Kaphle; Qing Ouyang; Michael Schmidt; Diana D. Shi; Milan R. Savani; Alexander C.-Y. Tsai; Joyce H. Lee; Ruth Gordillo; Javier Garcia-Bermudez; Yoon Jung Kim; Shih-Chia Tso; Chad A. Brautigam; Lauren G. Zacharias; Thomas P. Mathews; Lin Xu; John G. Doench; Vidyasagar Koduri; Kalil G. Abdullah; Michalis Agathocleous; Laura A. Banaszynski; Ralph J. DeBerardinis; Eric M. Morrow; Samuel K. McBrayer
CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials

CRISPR碱基编辑筛选确定了影响临床试验中menin抑制剂的MEN1突变谱

Nature Communications
IF15.7
2026-05-090
OAAI
Wallace Bourgeois; Hannah E. Rice; Daniela V. Wenge; Florian Perner; Hong Yue; Brandon D. Regalado; George Wan; Jan C. Schroeder; Alba Sommerschield; Charlie Hatton; Shivendra Singh; Sweta Singh; Shipra Bijpuria; Brian M. McKeever; William H. Miller; Jordan F. Safer; Sumaiya Iqbal; Jennifer A. Perry; Eric S. Fischer; John G. Doench; Gerard M. McGeehan; Jevon A. Cutler; Scott A. Armstrong
Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity

唾液酸化的CD43形成一种糖免疫屏障，该屏障可抑制抗白血病免疫。

Science
IF45.8
2026-04-090
PRE
Jooho Chung; Mounica Vallurupalli; Sarah Noel; Gail Schor; Sofia Mrowka; Ilario Scapozza; Zelalem Demere; Sachin V. Kammula; Margaret Hu; Sarah Y. Kim; YuhJong Liu; Celeste Nobrega; Jonathan J. Perera; Ewa Wrona; Collins K. Cheruiyot; Yunkang Lin; David W. Wu; Maria Saberi; Aidan Cruickshank; Elliot C. Woods; Cun Lan Chuong; Filippo Birocchi; Ashwin V. Kammula; Omar I. Avila; Nelson Knudsen; Mustafa Kocak; John G. Doench; Dean Procter; Lindsey Thornton; Andrew M. Brunner; Eric Winer; Daniel J. DeAngelo; Jacqueline S. Garcia; Richard M. Stone; Russell W. Jenkins; Marcela V. Maus; Timothy A. Graubert; Kathleen B. Yates; Todd R. Golub; Robert T. Manguso
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

体内CRISPR筛选鉴定多发性骨髓瘤中CAR T细胞功能修饰因子

Nature
IF48.5
2025-09-240
PRE
Nelson H. Knudsen; Giulia Escobar; Felix Korell; Tamina Kienka; Celeste Nobrega; Seth Anderson; Andrew Y. Cheng; Maria Zschummel; Alexander Armstrong; Amanda Bouffard; Michael C. Kann; Sadie Goncalves; Hans W. Pope; Mitra Pezeshki; Alexander Rojas; Juliette S. M. T. Suermondt; Merle Phillips; Trisha R. Berger; Sangwoo Park; Diego Salas-Benito; Elijah P. Darnell; Filippo Birocchi; Mark B. Leick; Rebecca C. Larson; John G. Doench; Debattama Sen; Kathleen B. Yates; Robert T. Manguso; Marcela V. Maus
Identification of Synthetic Lethal Vulnerabilities Between TRIM28 and NOTCH2 in Small Cell Lung Cancer Through CRISPR/Cas9 Screening

通过CRISPR/Cas9筛选鉴定小细胞肺癌中TRIM28与NOTCH2之间的合成致死易损性

Journal of Thoracic Oncology
IF20.8
2025-08-290
PRE
Deli Hong; Ying Lyu; Keita Masuzawa; Zoe Devos; Shin Saito; Qi Liu; Yixiang Li; Zhaorong Li; Leslie Duplaquet; Eric H. Knelson; Tran Thai; John G. Doench; David A. Barbie; Michael Y. Tolystorukov; Jun Qi; Yejing Ge; Matthew G. Oser
Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity

Cyclin A/B RxL 环状大环抑制剂用于治疗高 E2F 活性癌症

Journal of Thoracic Oncology
IF20.8
2025-08-290
PRE
Shilpa Singh; Catherine E. Gleason; Min Fang; Yasmin N. Laimon; Vishal Khivansara; Shanhai Xie; Yavuz T. Durmaz; Aniruddha Sarkar; Kenneth Ngo; Varunika Savla; Yixiang Li; Muhannad Abu-Remaileh; Xinyue Li; Bishma Tuladhar; Ranya Odeh; Frances Hamkins-Indik; Daphne He; Miles W. Membreno; Meisam Nosrati; Nathan N. Gushwa; Siegfried S.F. Leung; Breena Fraga-Walton; Luis Hernandez; Miguel P. Baldomero; Bryan M. Lent; David Spellmeyer; Joshua F. Luna; Dalena Hoang; Yuliana Gritsenko; Manesh Chand; Megan K. DeMart; Sammy Metobo; Chinmay Bhatt; Justin A. Shapiro; Kai Yang; Nathan J. Dupper; Andrew T. Bockus; John G. Doench; James B. Aggen; Li-Fen Liu; Bernard Levin; Evelyn W. Wang; Iolanda Vendrell; Roman Fischer; Benedikt Kessler; Prafulla C. Gokhale; Sabina Signoretti; Alexander Spektor; Constantine Kreatsoulas; Rajinder Singh; David J. Earp; Pablo D. Garcia; Deepak Nijhawan; Matthew G. Oser
Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

NOTCH2的缺失在小型细胞肺癌中引发了一种TRIM28依赖性的易感性。

Developmental Cell
IF8.7
2025-08-260
PRE
Deli Hong; Ying Lyu; Richa Nayak; Justin S. Becker; Matthew A. Booker; Keita Masuzawa; Zoe Devos; Tianchu Wang; Shin Saito; Qi Liu; Yixiang Li; Zhaorong Li; Eric H. Knelson; Tran Thai; Leslie Duplaquet; Yasmin N. Laimon; Gabriel Roberti De Oliveira; Sabina Signoretti; John G. Doench; David A. Barbie; Michael Y. Tolystorukov; Jun Qi; Bradley E. Bernstein; Yejing Ge; Matthew G. Oser
Targeting G1–S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors

靶向G1-S检验点受损的癌症，使用细胞周期蛋白A/B RxL抑制剂

Nature
IF48.5
2025-08-200
OA
Shilpa Singh; Catherine E. Gleason; Min Fang; Yasmin N. Laimon; Vishal Khivansara; Shanhai Xie; Yavuz T. Durmaz; Aniruddha Sarkar; Kenneth Ngo; Varunika Savla; Yixiang Li; Muhannad Abu-Remaileh; Xinyue Li; Marie-Anais Locquet; Bishma Tuladhar; Ranya Odeh; Frances Hamkins-Indik; Daphne He; Miles W. Membreno; Meisam Nosrati; Nathan N. Gushwa; Siegfried S. F. Leung; Breena Fraga-Walton; Luis Hernandez; Miguel P. Baldomero; Bryan M. Lent; David Spellmeyer; Joshua F. Luna; Dalena Hoang; Yuliana Gritsenko; Manesh Chand; Megan K. DeMart; Sammy Metobo; Chinmay Bhatt; Justin A. Shapiro; Kai Yang; Nathan J. Dupper; Andrew T. Bockus; Jinshu Fang; Ramesh Bambal; Peadar Cremin; John G. Doench; James B. Aggen; Li-Fen Liu; Bernard Levin; Evelyn W. Wang; Iolanda Vendrell; Roman Fischer; Benedikt Kessler; Prafulla C. Gokhale; Sabina Signoretti; Alexander Spektor; Constantine Kreatsoulas; Marie Evangelista; Rajinder Singh; David J. Earp; Deepak Nijhawan; Pablo D. Garcia; Matthew G. Oser
Morphological map of under- and overexpression of genes in human cells
Nature Methods
IF32.1
2025-08-070
PRE
Srinivas Niranj Chandrasekaran; Eric Alix; John Arevalo; Adriana Borowa; Patrick J. Byrne; William G. Charles; Zitong S. Chen; Beth A. Cimini; Boxiong Deng; John G. Doench; Jessica D. Ewald; Briana Fritchman; Colin J. Fuller; Jedidiah Gaetz; Amy Goodale; Marzieh Haghighi; Yu Han; Zahra Hanifehlou; Holger Hennig; Desiree Hernandez; Christina B. Jacob; Tim James; Tomasz Jetka; Alexandr A. Kalinin; Ben Komalo; Maria Kost-Alimova; Tomasz Krawiec; Brittany A. Marion; Glynn Martin; Nicola Jane McCarthy; Lisa Miller; Arne Monsees; Nikita Moshkov; Alán F. Muñoz; Arnaud Ogier; Magdalena Otrocka; Krzysztof Rataj; David E. Root; Francesco Rubbo; Simon Scrace; Douglas W. Selinger; Rebecca A. Senft; Peter Sommer; Amandine Thibaudeau; Sarah Trisorus; Rahul Valiya Veettil; William J. Van Trump; Sui Wang; Michał Warchoł; Erin Weisbart; Amélie Weiss; Michael Wiest; Agata Zaremba; Andrei Zinovyev; Shantanu Singh; Anne E. Carpenter
HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors

HKU5蝙蝠mers冠状病毒利用蝙蝠和貂ACE2作为进入受体

Nature Communications
IF15.7
2025-07-240
OAAI
Mia Madel Alfajaro; Emma L. Keeler; Ning Li; Nicholas J. Catanzaro; I-Ting Teng; Zhe Zhao; Michael W. Grunst; Boyd Yount; Alexandra Schäfer; Danyi Wang; Arthur S. Kim; Aleksandra Synowiec; Mario A. Peña-Hernández; Samantha Zepeda; Ridwan Arinola; Ramandeep Kaur; Bridget L. Menasche; Jin Wei; Gabriel A. Russell; John Huck; Jaewon Song; Aaron Ring; Akiko Iwasaki; Rohit K. Jangra; Sanghyun Lee; David R. Martinez; Walther Mothes; Pradeep D. Uchil; John G. Doench; Alicen B. Spaulding; Ralph S. Baric; Leonid Serebryannyy; Yaroslav Tsybovsky; Tongqing Zhou; Daniel C. Douek; Craig B. Wilen

研究方向

暂未获取到该数据
D
David E. Root
H 指数:106论文数:815被引数:6.9万
W
William C. Hahn
H 指数:147论文数:1,091被引数:10.1万
J
Jesse S. Boehm
H 指数:59论文数:332被引数:4.2万
M
Mudra Hegde
H 指数:19论文数:35被引数:9,393
T
Todd R. Golub
H 指数:176论文数:757被引数:26.6万
F
Francisca Vázquez
H 指数:76论文数:520被引数:3.3万
F
Federica Piccioni
H 指数:46论文数:359被引数:1.2万
P
Peter C. DeWeirdt
H 指数:17论文数:27被引数:2,062
J
Joshua M. Dempster
H 指数:27论文数:130被引数:4,428
A
Arlene H. Sharpe
H 指数:154论文数:744被引数:10.9万