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Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA SynthetaseACS INFECTIOUS DISEASESIF3.82022-08-2912OAAI
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An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel AntimalarialsJOURNAL OF MEDICINAL CHEMISTRYIF6.82021-11-0810OA
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Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine DerivativesACS MEDICINAL CHEMISTRY LETTERSIF42020-11-1013OAAI
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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosisPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAIF9.12019-03-20111OAAI
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovaniACS INFECTIOUS DISEASESIF3.82018-11-0153OAAI
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase InhibitorsJOURNAL OF MEDICINAL CHEMISTRYIF6.82018-09-1245OAAI
Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetaseACS INFECTIOUS DISEASESIF3.82016-11-1644OAAI
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles开源药物发现: 源自Tres Cantos芳基吡咯的高效抗疟化合物ACS CENTRAL SCIENCEIF10.42016-09-1454OAAI
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo EfficacyJOURNAL OF MEDICINAL CHEMISTRYIF6.82016-09-1071OAAI
Trisubstituted Pyrimidines as Efficacious and Fast-Acting AntimalarialsJOURNAL OF MEDICINAL CHEMISTRYIF6.82016-06-1713OAAI
Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma bruceiJOURNAL OF MEDICINAL CHEMISTRYIF6.82015-09-2935OAAI
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding ModeCHEMMEDCHEMIF3.42015-09-2323OAAI
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase LibraryCHEMMEDCHEMIF3.42015-09-1823OAAI