Brenda F. Baker - Publications, H-index & Citations

Brenda F. Baker

ionis pharmaceuticals inc.

50H指数

109论文数

1.2W被引数

收录论文 56

发表时间

Familial chylomicronemia syndrome and treatments to target hepatic APOC3 mRNA (vol 403, 119114, 2025)家族性乳糜微粒血症综合征及靶向肝脏APOC3 mRNA的治疗方法（卷403，119114，2025）

ATHEROSCLEROSIS

IF5.7

2025-06-01

PREAI

Brinton, Eliot A.; Eckel, Robert H.; Gaudet, Daniel; Ballantyne, Christie M.; Baker, Brenda F.; Ginsberg, Henry N.; Witztum, Joseph L.

Safety and Tolerability of GalNAc3-Conjugated Antisense Drugs Compared to the Same-Sequence 2′-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data

NUCLEIC ACID THERAPEUTICS

IF4.7

2024-02-01

OAAI

Baker, Brenda F.; Xia, Shuting; Partridge, Wesley; Engelhardt, Jeffery A.; Tsimikas, Sotirios; Crooke, Stanley T.; Bhanot, Sanjay; Geary, Richard S.

Integrated Assessment of Phase 2 Data on GalNAc3-Conjugated 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides GalNAc3-Conjugated 2'-O-甲氧基乙基修饰的反义寡核苷酸2期数据的综合评估

NUCLEIC ACID THERAPEUTICS

IF4.7

2023-02-01

OAAI

Baker, Brenda F. F.; Xia, Shuting; Partridge, Wesley; Kwoh, T. Jesse; Tsimikas, Sotirios; Bhanot, Sanjay; Geary, Richard S. S.

Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2023-01-31

OAAI

Partridge, Wesley; Burel, Sebastien A.; Ferng, Annie; Xia, Shuting; Kwoh, T. Jesse; Henry, Scott P.; Baker, Brenda F.

Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells

NUCLEIC ACID THERAPEUTICS

IF4.7

2022-12-01

PREAI

Burel, Sebastien A.; Machemer, Todd; Baker, Brenda F.; Kwoh, T. Jesse; Paz, Suzanne; Younis, Husam; Henry, Scott P.

Liver-directed drugs for transthyretin-mediated amyloidosis 转甲状腺素蛋白介导的淀粉样变性的肝导向药物

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

IF3.2

2022-11-16

OAAI

Brannagan, Thomas H.; Berk, John L.; Gillmore, Julian D.; Maurer, Mathew S.; Waddington-Cruz, Marcia; Fontana, Marianna; Masri, Ahmad; Obici, Laura; Brambatti, Michela; Baker, Brenda F.; Hannan, Lisa A.; Buchele, Gustavo; Viney, Nick J.; Coelho, Teresa; Nativi-Nicolau, Jose

Inhibition of Prekallikrein for Hereditary Angioedema

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2022-03-17

OAAI

Fijen, Laure M.; Riedl, Marc A.; Bordone, Laura; Bernstein, Jonathan A.; Raasch, Jason; Tachdjian, Raffi; Craig, Timothy; Lumry, William R.; Manning, Michael E.; Alexander, Veronica J.; Newman, Kenneth B.; Revenko, Alexey; Baker, Brenda F.; Nanavati, Charvi; MacLeod, A. Robert; Schneider, Eugene; Cohn, Danny M.

Improvements in the Tolerability Profile of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods

NUCLEIC ACID THERAPEUTICS

IF4.7

2021-12-01

OAAI

Partridge, Wesley; Xia, Shuting; Kwoh, T. Jesse; Bhanot, Sanjay; Geary, Richard S.; Baker, Brenda F.

Antisense drug discovery and development technology considered in a pharmacological context

BIOCHEMICAL PHARMACOLOGY

IF5.6

2021-07-01

PREAI

Crooke, Stanley T.; Liang, Xue-hai; Crooke, Rosanne M.; Baker, Brenda F.; Geary, Richard S.

Antisense technology: an overview and prospectus

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2021-03-24

426

PREAI

Crooke, Stanley T.; Baker, Brenda F.; Crooke, Rosanne M.; Liang, Xue-hai

Antisense technology: A review

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

165

OAAI

Crooke, Stanley T.; Liang, Xue-Hai; Baker, Brenda F.; Crooke, Rosanne M.

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

ESC HEART FAILURE

IF3.7

2020-12-07

OAAI

Viney, Nicholas J.; Guo, Shuling; Tai, Li-Jung; Baker, Brenda F.; Aghajan, Mariam; Jung, Shiangtung W.; Yu, Rosie Z.; Booten, Sheri; Murray, Heather; Machemer, Todd; Burel, Sebastien; Murray, Sue; Buchele, Gustavo; Tsimikas, Sotirios; Schneider, Eugene; Geary, Richard S.; Benson, Merrill D.; Monia, Brett P.

Antisense Inhibition of Prekallikrein to Control Hereditary Angioedema

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2020-09-24

OAAI

Cohn, Danny M.; Viney, Nicholas J.; Fijen, Laure M.; Schneider, Eugene; Alexander, Veronica J.; Xia, Shuting; Kaeser, Gwendolyn E.; Nanavati, Charvi; Baker, Brenda F.; Geary, Richard S.; Levi, Marcel; Meijers, Joost C. M.; Stroes, Erik S. G.

Novel antisense inhibition of diacylglycerol O-acyltransferase 2 for treatment of non-alcoholic fatty liver disease: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial

LANCET GASTROENTEROLOGY & HEPATOLOGY

IF38.6

2020-09-01

PREAI

Loomba, Rohit; Morgan, Erin; Watts, Lynnetta; Xia, Shuting; Hannan, Lisa A.; Geary, Richard S.; Baker, Brenda F.; Bhanot, Sanjay

Phase 1 Investigation of a Ligand-Conjugated Antisense Oligonucleotide with Increased Potency for the Treatment of Transthyretin Amyloidosis

JOURNAL OF CARDIAC FAILURE

IF8.2

2019-08-01

PREAI

Viney, Nicholas J.; Tai, Li-Jung; Jung, Shiangtung; Yu, Rosie Z.; Guthrie, Spencer; Baker, Brenda F.; Geary, Richard S.; Schneider, Eugene; Guo, Shuling; Monia, Brett P.

IONIS-PKKRx a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production

NUCLEIC ACID THERAPEUTICS

IF4.7

2019-04-01

OAAI

Ferrone, Jason D.; Bhattacharjee, Gourab; Revenko, Alexey S.; Zanardi, Thomas A.; Warren, Marshelle S.; Derosier, Frederick J.; Viney, Nicholas J.; Pham, Nguyen C.; Kaeser, Gwendolyn E.; Baker, Brenda F.; Schneider, Eugene; Hughes, Steven G.; Monia, Brett P.; MacLeod, A. Robert

Antisense Inhibition of Glucagon Receptor by IONIS-GCGRRx Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy

DIABETES CARE

IF16.6

2019-02-14

OAAI

Morgan, Erin S.; Tai, Li-Jung; Pham, Nguyen C.; Overman, Julia K.; Watts, Lynnetta M.; Smith, Anne; Jung, Shiangtung W.; Gajdosik, Martin; Krssak, Martin; Krebs, Michael; Geary, Richard S.; Baker, Brenda F.; Bhanot, Sanjay

Integrated Assessment of the Clinical Performance of GalNAc3-Conjugated 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience

NUCLEIC ACID THERAPEUTICS

IF4.7

2019-02-01

OAAI

Crooke, Stanley T.; Baker, Brenda F.; Xia, Shuting; Yu, Rosie Z.; Viney, Nicholas J.; Wang, Yanfeng; Tsimikas, Sotirios; Geary, Richard S.

RNA-Targeted Therapeutics (vol 27, pg 714, 2018)

CELL METABOLISM

IF30.9

2019-02-01

OAAI

Crooke, Stanley T.; Witztum, Joseph L.; Bennett, C. Frank; Baker, Brenda F.

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

NEW ENGLAND JOURNAL OF MEDICINE

IF78.5

2018-07-05

1.0K

OAAI

Benson, M. D.; Waddington-Cruz, M.; Berk, J. L.; Polydefkis, M.; Dyck, P. J.; Wang, A. K.; Plante-Bordeneuve, V.; Barroso, F. A.; Merlini, G.; Obici, L.; Scheinberg, M.; Brannagan, T. H., III; Litchy, W. J.; Whelan, C.; Drachman, B. M.; Adams, D.; Heitner, S. B.; Conceicao, I.; Schmidt, H. H.; Vita, G.; Campistol, J. M.; Gamez, J.; Gorevic, P. D.; Gane, E.; Shah, A. M.; Solomon, S. D.; Monia, B. P.; Hughes, S. G.; Kwoh, T. J.; McEvoy, B. W.; Jung, S. W.; Baker, B. F.; Ackermann, E. J.; Gertz, M. A.; Coelho, T.

研究方向