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J

Jennifer E. Klomp

University of North Carolina at Chapel Hill
H指数:20
被引数:2,382

个人简介

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教育背景

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工作经历

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荣誉奖项

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Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer

定义支持胰腺癌KRAS-和ERK依赖性生长的MYC调控转录组与激酶组

SCIENCE SIGNALING
IF6.6
2025-09-300
PRE
Hibshman, Priya S.; Stalnecker, Clint A.; Klomp, Jeffrey A.; Drizyte-Miller, Kristina; Klomp, Jennifer E.; Edwards, A. Cole; Pita, Lily M.; Hodge, Richard G.; Diehl, J. Nathaniel; Mouery, Ryan D.; Mouery, Brandon L.; Snare, Kayla R.; Waters, Andrew M.; Peng, Sen; Barker, Natalie K.; Pierobon, Mariaelena; Rashid, Naim U.; Tran, Nhan L.; Herring, Laura A.; Graves, Lee M.; Petricoin, Emanuel F.; Bryant, Kirsten L.; Cox, Adrienne D.; Der, Channing J.
Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
Science
IF45.8
2024-01-010
OA
Jeffrey A. Klomp; Jennifer E. Klomp; Clint A. Stalnecker; Kirsten L. Bryant; A. Cole Edwards; Kristina Drizyte‐Miller; Priya S. Hibshman; J. Nathaniel Diehl; Ye S. Lee; Alexis Jean Morales; Khalilah E. Taylor; Sen Peng; Nhan L. Tran; Laura E. Herring; Alex W. Prevatte; Natalie K. Barker; Laura D. Hover; Jill F. Hallin; Saikat Chowdhury; Oluwadara Coker; Hey Min Lee; Craig M. Goodwin; Prson Gautam; Peter Olson; James G. Christensen; John Paul Shen; Scott Kopetz; Lee M. Graves; Kian‐Huat Lim; Andrea Wang‐Gillam; Krister Wennerberg; Adrienne D. Cox; Channing J. Der
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
Science
IF45.8
2024-01-010
OA
Jennifer E. Klomp; J. Nathaniel Diehl; Jeffrey A. Klomp; A. Cole Edwards; Runying Y. Yang; Alexis Jean Morales; Khalilah E. Taylor; Kristina Drizyte‐Miller; Kirsten L. Bryant; Antje Schaefer; Jared Lee Johnson; Emily M. Huntsman; Tomer M. Yaron; Mariaelena Pierobon; Elisa Baldelli; Alex W. Prevatte; Natalie K. Barker; Laura E. Herring; Emanuel F. Petricoin; Lee M. Graves; Lewis C. Cantley; Adrienne D. Cox; Channing J. Der; Clint A. Stalnecker
TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors

TEAD抑制克服了YAP1/TAZ驱动的对KRASG12C抑制剂的原发性和获得性抗性

CANCER RESEARCH
IF16.6
2023-11-0718
OA
Edwards, A. Cole; Stalnecker, Clint A.; Morales, Alexis Jean; Taylor, Khalilah E.; Klomp, Jennifer E.; Klomp, Jeffrey A.; Waters, Andrew M.; Sudhakar, Niranjan; Hallin, Jill; Tang, Tracy T.; Olson, Peter; Post, Leonard; Christensen, James G.; Cox, Adrienne D.; Der, Channing J.
Determination of KRAS- and ERK-regulated phosphoproteomes in KRAS-mutant cancers
MOLECULAR CANCER RESEARCH
IF4.7
2023-05-010
PRE
Klomp, Jennifer E.; Klomp, Jeff A.; Diehl, Nathaniel J.; Edwards, Cole A.; Drizyte-Miller, Kristina; Hibshman, Priya S.; Yang, Runying; Morales, Alexis J.; Taylor, Khalilah E.; Pierobon, Mariaelena; Petricoin, Emanuel F., III; Jared, Johnson L.; Huntsman, Emily M.; Yaron, Tomer M.; Vaha-Koskela, Markus; Herring, Laura E.; Prevatte, Alex W.; Barker, Natalie K.; Graves, Lee M.; Krister, Wennerberg; Cantley, Lewis C.; Christensen, James G.; Cox, Adrienne D.; Der, Channing J.; Stalnecker, Clint A.
Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer

联合CDK4/6抑制剂治疗KRAS突变型胰腺癌

CANCER RESEARCH
IF16.6
2022-11-0857
OA
Goodwin, Craig M.; Waters, Andrew M.; Klomp, Jennifer E.; Javaid, Sehrish; Bryant, Kirsten L.; Stalnecker, Clint A.; Drizyte-Miller, Kristina; Papke, Bjoern; Yang, Runying; Amparo, Amber M.; Ozkan-Dagliyan, Irem; Baldelli, Elisa; Calvert, Valerie; Pierobon, Mariaelena; Sorrentino, Jessica A.; Beelen, Andrew P.; Bublitz, Natalie; Luethen, Mareen; Wood, Kris C.; Petricoin III, Emanuel F.; Sers, Christine; McRee, Autumn J.; Cox, Adrienne D.; Der, Channing J.
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer
JOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
2021-11-0121
OAAI
Diehl, J. Nathaniel; Klomp, Jennifer E.; Snare, Kayla R.; Hibshman, Priya S.; Blake, Devon R.; Kaiser, Zane D.; Gilbert, Thomas S. K.; Baldelli, Elisa; Pierobon, Mariaelena; Papke, Bjorn; Yang, Runying; Hodge, Richard G.; Rashid, Naim U.; Petricoin, Emanuel F., III; Herring, Laura E.; Graves, Lee M.; Cox, Adrienne D.; Der, Channing J.
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

CHK1保护致癌KRAS表达细胞免受DNA损伤，是胰腺癌治疗的靶点

CELL REPORTS
IF6.9
2021-11-0123
OAAI
Klomp, Jennifer E.; Lee, Ye S.; Goodwin, Craig M.; Papke, Bjorn; Klomp, Jeff A.; Waters, Andrew M.; Stalnecker, Clint A.; DeLiberty, Jonathan M.; Drizyte-Miller, Kristina; Yang, Runying; Diehl, J. Nathaniel; Yin, Hongwei H.; Pierobon, Mariaelena; Baldelli, Elisa; Ryan, Meagan B.; Li, Siqi; Peterson, Jackson; Smith, Amber R.; Neal, James T.; McCormick, Aaron K.; Kuo, Calvin J.; Counter, Christopher M.; Petricoin, Emanuel F.; Cox, Adrienne D.; Bryant, Kirsten L.; Der, Channing J.
Targeting p130Cas-and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

靶向p130Cas-and微管依赖的MYC调节使胰腺癌对ERK MAPK抑制敏感

CELL REPORTS
IF6.9
2021-06-0118
OAAI
Waters, Andrew M.; Khatib, Tala O.; Papke, Bjoern; Goodwin, Craig M.; Hobbs, G. Aaron; Diehl, J. Nathaniel; Yang, Runying; Edwards, A. Cole; Walsh, Katherine H.; Sulahian, Rita; McFarland, James M.; Kapner, Kevin S.; Gilbert, Thomas S. K.; Stalnecker, Clint A.; Javaid, Sehrish; Barkovskaya, Anna; Grover, Kajal R.; Hibshman, Priya S.; Blake, Devon R.; Schaefer, Antje; Nowak, Katherine M.; Klomp, Jennifer E.; Hayes, Tikvah K.; Kassner, Michelle; Tang, Nanyun; Tanaseichuk, Olga; Chen, Kaisheng; Zhou, Yingyao; Kalkat, Manpreet; Herring, Laura E.; Graves, Lee M.; Penn, Linda Z.; Yin, Hongwei H.; Aguirre, Andrew J.; Hahn, William C.; Cox, Adrienne D.; Der, Channing J.
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer (vol 25, pg 628, 2019)

ERK和自噬抑制的组合作为胰腺癌的治疗方法 (第25卷，628页，2019)

NATURE MEDICINE
IF50
2020-06-0117
OAAI
Bryant, Kirsten L.; Stalnecker, Clint A.; Zeitouni, Daniel; Klomp, Jennifer E.; Peng, Sen; Tikunov, Andrey P.; Gunda, Venugopal; Pierobon, Mariaelena; Waters, Andrew M.; George, Samuel D.; Tomar, Garima; Papke, Bjorn; Hobbs, G. Aaron; Yan, Liang; Hayes, Tikvah K.; Diehl, J. Nathaniel; Goode, Gennifer D.; Chaika, Nina V.; Wang, Yingxue; Zhang, Guo-Fang; Witkiewicz, Agnieszka K.; Knudsen, Erik S.; Petricoin, Emanuel F., III; Singh, Pankaj K.; Macdonald, Jeffrey M.; Tran, Nhan L.; Lyssiotis, Costas A.; Ying, Haoqiang; Kimmelman, Alec C.; Cox, Adrienne D.; Der, Channing J.
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

非典型KRASG12R突变体在胰腺癌的PI3K信号传导和巨胞饮作用中受损

CANCER DISCOVERY
IF33.3
2020-01-09139
OAAI
Hobbs, G. Aaron; Baker, Nicole M.; Miermont, Anne M.; Thurman, Ryan D.; Pierobon, Mariaelena; Tran, Timothy H.; Anderson, Andrew O.; Waters, Andrew M.; Diehl, J. Nathaniel; Papke, Bjoern; Hodge, Richard G.; Klomp, Jennifer E.; Goodwin, Craig M.; DeLiberty, Jonathan M.; Wang, Junning; Ng, Raymond W. S.; Gautam, Prson; Bryant, Kirsten L.; Esposito, Dominic; Campbell, Sharon L.; Petricoin, Emanuel F., III; Simanshu, Dhirendra K.; Aguirre, Andrew J.; Wolpin, Brian M.; Wennerberg, Krister; Rudloff, Udo; Cox, Adrienne D.; Der, Channing J.
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

ERK联合自噬抑制治疗胰腺癌的研究进展

NATURE MEDICINE
IF50
2019-03-04526
OAAI
Bryant, Kirsten L.; Stalnecker, Clint A.; Zeitouni, Daniel; Klomp, Jennifer E.; Peng, Sen; Tikunov, Andrey P.; Gunda, Venugopal; Pierobon, Mariaelena; Waters, Andrew M.; George, Samuel D.; Tomar, Garima; Papke, Bjorn; Hobbs, G. Aaron; Yan, Liang; Hayes, Tikvah K.; Diehl, J. Nathaniel; Goode, Gennifer D.; Chaika, Nina V.; Wang, Yingxue; Zhang, Guo-Fang; Witkiewicz, Agnieszka K.; Knudsen, Erik S.; Petricoin, Emanuel F., III; Singh, Pankaj K.; Macdonald, Jeffrey M.; Tran, Nhan L.; Lyssiotis, Costas A.; Ying, Haoqiang; Kimmelman, Alec C.; Cox, Adrienne D.; Der, Channing J.

研究方向

暂未获取到该数据
C
Channing J. Der
H 指数:127论文数:1,046被引数:7.1万
A
Adrienne D. Cox
H 指数:73论文数:517被引数:1.9万
C
Clint A. Stalnecker
H 指数:17论文数:211被引数:4,401
K
Kirsten L. Bryant
H 指数:20论文数:200被引数:3,505
M
Mariaelena Pierobon
H 指数:39论文数:385被引数:7,072
J
J. Nathaniel Diehl
H 指数:18论文数:49被引数:1,836
A
Andrew M. Waters
H 指数:18论文数:348被引数:3,008
J
Jeffrey A. Klomp
H 指数:18论文数:93被引数:1,030
B
Bjoern Papke
H 指数:16论文数:134被引数:2,981
E
Emanuel F. Petricoin
H 指数:81论文数:627被引数:2.8万