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A highly efficient transgene knock-in technology in clinically relevant cell types Allen, Alexander G.; Khan, Samia Q.; Margulies, Carrie M.; Viswanathan, Ramya; Lele, Swarali; Blaha, Laura; Scott, Sean N.; Izzo, Kaitlyn M.; Gerew, Alexandra; Pattali, Rithu; Cochran, Nadire R.; Holland, Carl S.; Zhao, Amy H.; Sherman, Stephen E.; Jaskolka, Michael C.; Wu, Meng; Wilson, Aaron C.; Sun, Xiaoqi; Ciulla, Dawn M.; Zhang, Deric; Nelson, Jacqueline D.; Zhang, Peisheng; Mazzucato, Patrizia; Huang, Yan; Giannoukos, Georgia; Marco, Eugenio; Nehil, Michael; Follit, John A.; Chang, Kai-Hsin; Shearman, Mark S.; Wilson, Christopher J.; Zuris, John A. 分享 收藏
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Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders Bonazzi, Simone; Goold, Carleton P.; Gray, Audrey; Thomsen, Noel M.; Nunez, Jill; Karki, Rajeshri G.; Gorde, Aakruti; Biag, Jonathan D.; Malik, Hasnain A.; Sun, Yingchuan; Liang, Guiqing; Lubicka, Danuta; Salas, Sarah; Labbe-Giguere, Nancy; Keaney, Erin P.; McTighe, Stephanie; Liu, Shanming; Deng, Lin; Piizzi, Grazia; Lombardo, Franco; Burdette, Doug; Dodart, Jean-Cosme; Wilson, Christopher J.; Peukert, Stefan; Curtis, Daniel; Hamann, Lawrence G.; Murphy, Leon O. 分享 收藏
Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles Manthei, Kelly A.; Patra, Dhabaleswar; Wilson, Christopher J.; Fawaz, Maria V.; Piersimoni, Lolita; Shenkar, Jenny Capua; Yuan, Wenmin; Andrews, Philip C.; Engen, John R.; Schwendeman, Anna; Ohi, Melanie D.; Tesmer, John J. G. 分享 收藏
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Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10 Maeder, Morgan L.; Stefanidakis, Michael; Wilson, Christopher J.; Baral, Reshica; Barrera, Luis Alberto; Bounoutas, George S.; Bumcrot, David; Chao, Hoson; Ciulla, Dawn M.; DaSilva, Jennifer A.; Dass, Abhishek; Dhanapal, Vidya; Fennell, Tim J.; Friedland, Ari E.; Giannoukos, Georgia; Gloskowski, Sebastian W.; Glucksmann, Alexandra; Gotta, Gregory M.; Jayaram, Hariharan; Haskett, Scott J.; Hopkins, Bei; Horng, Joy E.; Joshi, Shivangi; Marco, Eugenio; Mepani, Rina; Reyon, Deepak; Ta, Terence; Tabbaa, Diana G.; Samuelsson, Steven J.; Shen, Shen; Skor, Maxwell N.; Stetkiewicz, Pam; Wang, Tongyao; Yudkoff, Clifford; Myer, Vic E.; Albright, Charles F.; Jiang, Haiyan 分享 收藏
Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells (vol 9, 2962, 2018) Tycko, Josh; Barrera, Luis A.; Huston, Nicholas C.; Friedland, Ari E.; Wu, Xuebing; Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Myer, Vic E.; Wilson, Christopher J.; Hsu, Patrick D. 分享 收藏
Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells Tycko, Josh; Barrera, Luis A.; Huston, Nicholas C.; Friedland, Ari E.; Wu, Xuebing; Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Myer, Vic E.; Wilson, Christopher J.; Hsu, Patrick D. 分享 收藏
Unexpected mutations after CRISPR-Cas9 editing in vivo Wilson, Christopher J.; Fennell, Tim; Bothmer, Anne; Maeder, Morgan L.; Reyon, Deepak; Cotta-Ramusino, Cecilia; Fernandez, Cecilia A.; Marco, Eugenio; Barrera, Luis A.; Jayaram, Hariharan; Albright, Charles F.; Cox, Gerald F.; Church, George M.; Myer, Vic E. 分享 收藏
UDiTaS™, a genome editing detection method for indels and genome rearrangements Giannoukos, Georgia; Ciulla, Dawn M.; Marco, Eugenio; Abdulkerim, Hayat S.; Barrera, Luis A.; Bothmer, Anne; Dhanapal, Vidya; Gloskowski, Sebastian W.; Jayaram, Hariharan; Maeder, Morgan L.; Skor, Maxwell N.; Wang, Tongyao; Myer, Vic E.; Wilson, Christopher J. 分享 收藏
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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo 选择性VPS34抑制剂阻断自噬并揭示NCOA4在体内铁蛋白降解和铁稳态中的作用 Dowdle, William E.; Nyfeler, Beat; Nagel, Jane; Elling, Robert A.; Liu, Shanming; Triantafellow, Ellen; Menon, Suchithra; Wang, Zuncai; Honda, Ayako; Pardee, Gwynn; Cantwell, John; Luu, Catherine; Cornella-Taracido, Ivan; Harrington, Edmund; Fekkes, Peter; Lei, Hong; Fang, Qing; Digan, Mary Ellen; Burdick, Debra; Powers, Andrew F.; Helliwell, Stephen B.; D'Aquin, Simon; Bastien, Julie; Wang, Henry; Wiederschain, Dmitri; Kuerth, Jenny; Bergman, Philip; Schwalb, David; Thomas, Jason; Ugwonali, Savuth; Harbinski, Fred; Tallarico, John; Wilson, Christopher J.; Myer, Vic E.; Porter, Jeffery A.; Bussiere, Dirksen E.; Finan, Peter M.; Labow, Mark A.; Mao, Xiaohong; Hamann, Lawrence G.; Manning, Brendan D.; Valdez, Reginald A.; Nicholson, Thomas; Schirle, Markus; Knapp, Mark S.; Keaney, Erin P.; Murphy, Leon O. 分享 收藏
Identification of Mixed Lineage Leukemia 1(MLL1) Protein as a Coactivator of Heat Shock Factor 1(HSF1) Protein in Response to Heat Shock Protein 90 (HSP90) Inhibition Chen, Yaoyu; Chen, Jinyun; Yu, Jianjun; Yang, Guizhi; Temple, Emilia; Harbinski, Fred; Gao, Hui; Wilson, Christopher; Pagliarini, Raymond; Zhou, Wenlai 分享 收藏
Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials 新型特异性PI3Kα 抑制剂NVP-BYL719的特征和临床试验患者分层策略的发展 Fritsch, Christine; Huang, Alan; Chatenay-Rivauday, Christian; Schnell, Christian; Reddy, Anupama; Liu, Manway; Kauffmann, Audrey; Guthy, Daniel; Erdmann, Dirk; De Pover, Alain; Furet, Pascal; Gao, Hui; Ferretti, Stephane; Wang, Youzhen; Trappe, Joerg; Brachmann, Saskia M.; Maira, Sauveur-Michel; Wilson, Christopher; Boehm, Markus; Garcia-Echeverria, Carlos; Chene, Patrick; Wiesmann, Marion; Cozens, Robert; Lehar, Joseph; Schlegel, Robert; Caravatti, Giorgio; Hofmann, Francesco; Sellers, William R. 分享 收藏
Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers Garcia, Pablo D.; Langowski, John L.; Wang, Yingyun; Chen, Min; Castillo, Joseph; Fanton, Christie; Ison, Marjorie; Zavorotinskaya, Tatiana; Dai, Yumin; Lu, Jing; Niu, Xiao-Hong; Basham, Stephen; Chan, Julie; Yu, Jianjun; Doyle, Michael; Feucht, Paul; Warne, Robert; Narberes, Jamie; Tsang, Tiffany; Fritsch, Christine; Kauffmann, Audrey; Pfister, Estelle; Drueckes, Peter; Trappe, Joerg; Wilson, Christopher; Han, Wooseok; Lan, Jiong; Nishiguchi, Gisele; Lindvall, Mika; Bellamacina, Cornelia; Aycinena, J. Alex; Zang, Richard; Holash, Jocelyn; Burger, Matthew T. 分享 收藏
Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation Xie, Yang; Avello, Monika; Schirle, Markus; McWhinnie, Elizabeth; Feng, Yan; Bric-Furlong, Eva; Wilson, Christopher; Nathans, Robin; Zhang, Jing; Kirschner, Marc W.; Huang, Shih-Min A.; Cong, Feng 分享 收藏
FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor FGFR遗传改变预测对选择性泛FGFR抑制剂NVP-BGJ398的敏感性 Guagnano, Vito; Kauffmann, Audrey; Woehrle, Simon; Stamm, Christelle; Ito, Moriko; Barys, Louise; Pornon, Astrid; Yao, Yao; Li, Fang; Zhang, Yun; Chen, Zhi; Wilson, Christopher J.; Bordas, Vincent; Le Douget, Mickael; Gaither, L. Alex; Borawski, Jason; Monahan, John E.; Venkatesan, Kavitha; Bruemmendorf, Thomas; Thomas, David M.; Garcia-Echeverria, Carlos; Hofmann, Francesco; Sellers, William R.; Graus-Porta, Diana 分享 收藏
Rescue Screens with Secreted Proteins Reveal Compensatory Potential of Receptor Tyrosine Kinases in Driving Cancer Growth Harbinski, Fred; Craig, Vanessa J.; Sanghavi, Sneha; Jeffery, Douglas; Liu, Lijuan; Sheppard, Kelly Ann; Wagner, Sabrina; Stamm, Christelle; Buness, Andreas; Chatenay-Rivauday, Christian; Yao, Yao; He, Feng; Lu, Chris X.; Guagnano, Vito; Metz, Thomas; Finan, Peter M.; Hofmann, Francesco; Sellers, William R.; Porter, Jeffrey A.; Myer, Vic E.; Graus-Porta, Diana; Wilson, Christopher J.; Buckler, Alan; Tiedt, Ralph 分享 收藏
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