Markus Boehm

Pfizer

H指数:31

被引数:8,219

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Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue model

在肥厚型心肌病工程组织模型中，发现可改变收缩特性的细丝小分子调节剂

Journal of Biological Chemistry

IF3.9

2025-11-130

OAAI

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-02-1915

PRE

Garnsey, Michelle R.; Smith, Aaron C.; Polivkova, Jana; Arons, Autumn L.; Bai, Guoyun; Blakemore, Caroline; Boehm, Markus; Buzon, Leanne M.; Campion, Sarah N.; Cerny, Matthew; Chang, Shiao-Chi; Coffman, Karen; Farley, Kathleen A.; Fonseca, Kari R.; Ford, Kristen K.; Garren, Jeonifer; Kong, Jimmy X.; Koos, Martin R. M.; Kung, Daniel W.; Lian, Yajing; Li, Monica M.; Li, Qifang; Martinez-Alsina, Luis A.; O'Connor, Rebecca; Ogilvie, Kevin; Omoto, Kiyoyuki; Raymer, Brian; Reese, Matthew R.; Ryder, Tim; Samp, Lacey; Stevens, Kimberly A.; Widlicka, Daniel W.; Yang, Qingyi; Zhu, Kaicheng; Fortin, Jean-Philippe; Sammons, Matthew F.

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-11-0214

PRE

Futatsugi, Kentaro; Cabral, Shawn; Kung, Daniel W.; Huard, Kim; Lee, Esther; Boehm, Markus; Bauman, Jonathan; Clark, Ronald W.; Coffey, Steven B.; Crowley, Collin; Dechert-Schmitt, Anne-Marie; Dowling, Matthew S.; Dullea, Robert; Gosset, James R.; Kalgutkar, Amit S.; Kou, Kou; Li, Qifang; Lian, Yajing; Loria, Paula M.; Londregan, Allyn T.; Niosi, Mark; Orozco, Christine; Pettersen, John C.; Pfefferkorn, Jeffrey A.; Polivkova, Jana; Ross, Trenton T.; Sharma, Raman; Stock, Ingrid A.; Tesz, Gregory; Wisniewska, Hanna; Goodwin, Bryan; Price, David A.

Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-01-0410

Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel β-Arrestin Antagonist Activity

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-05-1411

OAAI

Cosolvent-Enhanced Sampling and Unbiased Identification of Cryptic Pockets Suitable for Structure-Based Drug Design

JOURNAL OF CHEMICAL THEORY AND COMPUTATION

IF5.5

2019-04-1830

PREAI

Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1)

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-04-1227

OAAI

Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-04-0822

PREAI

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-01-264

OAAI

Diabetes area patent participation analysis - part II: years 2011-2016

EXPERT OPINION ON THERAPEUTIC PATENTS

IF4.6

2017-11-298

PREAI

Ensemble- and Rigidity Theory-Based Perturbation Approach To Analyze Dynamic Allostery

JOURNAL OF CHEMICAL THEORY AND COMPUTATION

IF5.5

2017-11-2726

PRE

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-10-3059

OAAI

Boehm, Markus; Beaumont, Kevin; Jones, Rhys; Kalgutkar, Amit S.; Zhang, Liying; Atkinson, Karen; Bai, Guoyun; Brown, Janice A.; Eng, Heather; Goetz, Gilles H.; Holder, Brian R.; Khunte, Bhagyashree; Lazzaro, Sarah; Limberakis, Chris; Ryu, Sangwoo; Shapiro, Michael J.; Tylaska, Laurie; Yan, Jiangli; Turner, Rushia; Leung, Siegfried S. F.; Ramaseshan, Mahesh; Price, David A.; Liras, Spiros; Jacobson, Matthew P.; Earp, David J.; Lokey, R. Scott; Mathiowetz, Alan M.; Menhaji-Klotz, Elnaz

A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation

CELL CHEMICAL BIOLOGY

IF7.2

2016-11-0186

OAAI

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

发现和临床前表征6-氯-5-[4-(1-羟基环丁基) 苯基]-1h-吲哚-3-羧酸 (PF-06409577)，一磷酸腺苷激活的蛋白激酶 (AMPK) 的直接激活剂，用于糖尿病肾病的潜在治疗

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-08-20109

OAAI

Cameron, Kimberly O.; Kung, Daniel W.; Kalgutkar, Amit S.; Kurumbail, Ravi G.; Miller, Russell; Salatto, Christopher T.; Ward, Jessica; Withka, Jane M.; Bhattacharya, Samit K.; Boehm, Markus; Borzilleri, Kris A.; Brown, Janice A.; Calabrese, Matthew; Caspers, Nicole L.; Cokorinos, Emily; Conn, Edward L.; Dowling, Matthew S.; Edmonds, David J.; Eng, Heather; Fernando, Dilinie P.; Frisbie, Richard; Hepworth, David; Landro, James; Mao, Yuxia; Rajamohan, Francis; Reyes, Allan R.; Rose, Colin R.; Ryder, Tim; Shavnya, Andre; Smith, Aaron C.; Tu, Meihua; Wolford, Angela C.; Xiao, Jun

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism

ACS CHEMICAL BIOLOGY

IF3.8

2016-07-1917

OAAI

Ahn, Kay; Boehm, Markus; Brown, Matthew F.; Calloway, Jessica; Che, Ye; Chen, Jinshan; Fennell, Kimberly F.; Geoghegan, Kieran F.; Gilbert, Adam M.; Gutierrez, Jemy A.; Kalgutkar, Amit S.; Lanba, Adhiraj; Limberalds, Chris; Magee, Thomas V.; O'Doherty, Inish; Oliver, Robert; Pabst, Brandon; Pandit, Jayvardhan; Parris, Kevin; Pfefferkorn, Jeffrey A.; Rolph, Timothy P.; Patel, Rushi; Schuff, Brandon; Shanmugasundaram, Veerabahu; Starr, Jeremy T.; Varghese, Alison H.; Vera, Nicholas B.; Vernochet, Cecile; Yan, Jiangli

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-09-1568

PREAI

Futatsugi, Kentaro; Kung, Daniel W.; Orr, Suvi T. M.; Cabral, Shawn; Hepworth, David; Aspnes, Gary; Bader, Scott; Bian, Jianwei; Boehm, Markus; Carpino, Philip A.; Coffey, Steven B.; Dowling, Matthew S.; Herr, Michael; Jiao, Wenhua; Lavergne, Sophie Y.; Li, Qifang; Clark, Ronald W.; Erion, Derek M.; Kou, Kou; Lee, Kyuha; Pabst, Brandon A.; Perez, Sylvie M.; Purkal, Julie; Jorgensen, Csilla C.; Goosen, Theunis C.; Gosset, James R.; Niosi, Mark; Pettersen, John C.; Pfefferkorn, Jeffrey A.; Ahn, Kay; Goodwin, Bryan

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-09-0816

PREAI

Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models of melanoma identify c-Met as an effective second line combination therapy target

CANCER RESEARCH

IF16.6

2015-08-010

PRE

Combined MEK1/2 and PI3K inhibition induces synergistic caspase-dependent apoptosis in neuroblastoma

CANCER RESEARCH