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A

Amit S. Kalgutkar

pfizer research & development
H指数:61
被引数:1.5万

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Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Ervogastat, a Diacylglycerol Acyltransferase 2 (DGAT2) Inhibitor, and Clesacostat, an Acetyl-CoA Carboxylase (ACC) Inhibitor

不同程度肝功能损伤对Ervogastat（一种二酰基甘油酰基转移酶2 [DGAT2] 抑制剂）和Clesacostat（一种乙酰辅酶A羧化酶 [ACC] 抑制剂）药代动力学的影响

JOURNAL OF CLINICAL PHARMACOLOGY
IF2.3
2025-09-010
PRE
Vourvahis, Manoli; Bergman, Arthur J.; Ogden, Adam G.; Hughes, Jim; Gosset, James R.; Kalgutkar, Amit S.; Amin, Neeta B.
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-11-190
PRE
Filipski, Kevin J.; Martinez-Alsina, Luis A.; Reese, Matthew R.; Evrard, Edelweiss; Buzon, Leanne M.; Cameron, Kimberly O.; Zhang, Yuan; Coffman, Karen J.; Bradow, James; Kormos, Bethany L.; Liu, Shenping; Knafels, John D.; Sahasrabudhe, Parag V.; Chen, Jie; Kalgutkar, Amit S.; Bessire, Andrew J.; Orozco, Christine C.; Balesano, Amanda; Cerny, Matthew A.; Bollinger, Eliza; Reyes, Allan R.; Laforest, Brigitte; Rosado, Amy; Williams, George; Marshall, Mackenzie; Neale, Kelly Tam; Chen, Xian; Hirenallur-Shanthappa, Dinesh; Stansfield, John C.; Groarke, John; Qiu, Ruolun; Karas, Spinel; Flach, Rachel J. Roth; Esler, William P.
Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model
SCIENCE ADVANCES
IF12.5
2024-08-302
OAAI
Garnsey, Michelle R.; Robinson, Matthew C.; Nguyen, Luong T.; Cardin, Rhonda; Tillotson, Joseph; Mashalidis, Ellene; Yu, Aijia; Aschenbrenner, Lisa; Balesano, Amanda; Behzadi, Amin; Boras, Britton; Chang, Jeanne S.; Eng, Heather; Ephron, Andrew; Foley, Tim; Ford, Kristen K.; Frick, James M.; Gibson, Scott; Hao, Li; Hurst, Brett; Kalgutkar, Amit S.; Korczynska, Magdalena; Lengyel-Zhand, Zsofia; Gao, Liping; Meredith, Hannah R.; Patel, Nandini C.; Polivkova, Jana; Rai, Devendra; Rose, Colin R.; Rothan, Hussin; Sakata, Sylvie K.; Vargo, Thomas R.; Qi, Wenying; Wu, Huixian; Liu, Yiping; Yurgelonis, Irina; Zhang, Jinzhi; Zhu, Yuao; Zhang, Lei; Lee, Alpha A.
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-04-3016
OAAI
Allerton, Charlotte M. N.; Arcari, Joel T.; Aschenbrenner, Lisa M.; Avery, Melissa; Bechle, Bruce M.; Behzadi, Mohammad Amin; Boras, Britton; Buzon, Leanne M.; Cardin, Rhonda D.; Catlin, Natasha R.; Carlo, Anthony A.; Coffman, Karen J.; Dantonio, Alyssa; Di, Li; Eng, Heather; Farley, Kathleen A.; Ferre, Rose Ann; Gernhardt, Steven S.; Gibson, Scott A.; Greasley, Samantha E.; Greenfield, Siennah R.; Hurst, Brett L.; Kalgutkar, Amit S.; Kimoto, Emi; Lanyon, Lorraine F.; Lovett, Gabrielle H.; Lian, Yajing; Liu, Wei; Alsina, Luis A. Martinez; Noell, Stephen; Obach, R. Scott; Owen, Dafydd R.; Patel, Nandini C.; Rai, Devendra K.; Reese, Matthew R.; Rothan, Hussin A.; Sakata, Sylvie; Sammons, Matthew F.; Sathish, Jean G.; Sharma, Raman; Steppan, Claire M.; Tuttle, Jamison B.; Verhoest, Patrick R.; Wei, Liuqing; Yang, Qingyi; Yurgelonis, Irina; Zhu, Yuao
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-11-0214
PRE
Futatsugi, Kentaro; Cabral, Shawn; Kung, Daniel W.; Huard, Kim; Lee, Esther; Boehm, Markus; Bauman, Jonathan; Clark, Ronald W.; Coffey, Steven B.; Crowley, Collin; Dechert-Schmitt, Anne-Marie; Dowling, Matthew S.; Dullea, Robert; Gosset, James R.; Kalgutkar, Amit S.; Kou, Kou; Li, Qifang; Lian, Yajing; Loria, Paula M.; Londregan, Allyn T.; Niosi, Mark; Orozco, Christine; Pettersen, John C.; Pfefferkorn, Jeffrey A.; Polivkova, Jana; Ross, Trenton T.; Sharma, Raman; Stock, Ingrid A.; Tesz, Gregory; Wisniewska, Hanna; Goodwin, Bryan; Price, David A.
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-06-0160
OAAI
Griffith, David A.; Edmonds, David J.; Fortin, Jean-Philippe; Kalgutkar, Amit S.; Kuzmiski, J. Brent; Loria, Paula M.; Saxena, Aditi R.; Bagley, Scott W.; Buckeridge, Clare; Curto, John M.; Derksen, David R.; Dias, Joao M.; Griffor, Matthew C.; Han, Seungil; Jackson, V. Margaret; Landis, Margaret S.; Lettiere, Daniel; Limberakis, Chris; Liu, Yuhang; Mathiowetz, Alan M.; Patel, Jayesh C.; Piotrowski, David W.; Price, David A.; Ruggeri, Roger B.; Tess, David A.
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™
INTERNATIONAL JOURNAL OF TOXICOLOGY
IF1
2022-05-2114
OA
Sathish, Jean G.; Bhatt, Siddhartha; DaSilva, Jamie K.; Flynn, Declan; Jenkinson, Stephen; Kalgutkar, Amit S.; Liu, Maggie; Manickam, Balasubramanian; Pinkstaff, Jason; Reagan, William J.; Shirai, Norimitsu; Shoieb, Ahmed M.; Sirivelu, Madhu; Vispute, Saurabh; Vitsky, Allison; Walters, Karen; Wisialowski, Todd A.; Updyke, Lawrence W.
Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities

建立药品N-亚硝胺杂质可接受摄入量的实用和科学策略

CHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
2022-02-2558
OAAI
Dobo, Krista L.; Kenyon, Michelle O.; Dirat, Olivier; Engel, Maria; Fleetwood, Andrew; Martin, Matthew; Mattano, Susan; Musso, Alyssa; McWilliams, James Christopher; Papanikolaou, Alexandros; Parris, Patricia; Whritenour, Jessica; Yu, Shu; Kalgutkar, Amit S.

研究方向

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L
Lawrence J. Marnett
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D
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R
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R
R. Scott Obach
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T
Tim F. Ryder
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J
Jessica Ward
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G
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H 指数:29论文数:72被引数:2,471
D
David A. Tess
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M
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