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Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells Fauser, Friedrich; Kadam, Bhakti N.; Arangundy-Franklin, Sebastian; Davis, Jessica E.; Vaidya, Vishvesha; Schmidt, Nicola J.; Lew, Garrett; Xia, Danny F.; Mureli, Rakshaa; Ng, Colman; Zhou, Yuanyue; Scarlott, Nicholas A.; Eshleman, Jason; Bendana, Yuri R.; Shivak, David A.; Reik, Andreas; Li, Patrick; Davis, Gregory D.; Miller, Jeffrey C. 分享 收藏
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors Wegmann, Susanne; DeVos, Sarah L.; Zeitler, Bryan; Marlen, Kimberly; Bennett, Rachel E.; Perez-Rando, Marta; MacKenzie, Danny; Yu, Qi; Commins, Caitlin; Bannon, Riley N.; Corjuc, Bianca T.; Chase, Alison; Diez, Lisa; Nguyen, Hoang-Oanh B.; Hinkley, Sarah; Zhang, Lei; Goodwin, Alicia; Ledeboer, Annemarie; Lam, Stephen; Ankoudinova, Irina; Hung Tran; Scarlott, Nicholas; Amora, Rainier; Surosky, Richard; Miller, Jeffrey C.; Robbins, Ashley B.; Rebar, Edward J.; Urnov, Fyodor D.; Holmes, Michael C.; Pooler, Amy M.; Riley, Brigit; Zhang, H. Steve; Hyman, Bradley T. 分享 收藏
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Enhancing gene editing specificity by attenuating DNA cleavage kinetics Miller, Jeffrey C.; Patil, Deepak P.; Xia, Danny F.; Paine, Charles B.; Fauser, Friedrich; Richards, Hunter W.; Shivak, David A.; Bendana, Yuri R.; Hinkley, Sarah J.; Scarlott, Nicholas A.; Lam, Stephen C.; Reik, Andreas; Zhou, Yuanyue; Paschon, David E.; Li, Patrick; Wangzor, Tenzin; Lee, Gary; Zhang, Lei; Rebar, Edward J. 分享 收藏
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease Zeitler, Bryan; Froelich, Steven; Marlen, Kimberly; Shivak, David A.; Yu, Qi; Li, Davis; Pearl, Jocelynn R.; Miller, Jeffrey C.; Zhang, Lei; Paschon, David E.; Hinkley, Sarah J.; Ankoudinova, Irina; Lam, Stephen; Guschin, Dmitry; Kopan, Lexi; Cherone, Jennifer M.; Nguyen, Hoang-Oanh B.; Qiao, Guijuan; Ataei, Yasaman; Mendel, Matthew C.; Amora, Rainier; Surosky, Richard; Laganiere, Josee; Vu, B. Joseph; Narayanan, Anand; Sedaghat, Yalda; Tillack, Karsten; Thiede, Christina; Gaertner, Annette; Kwak, Seung; Bard, Jonathan; Mrzljak, Ladislav; Park, Larry; Heikkinen, Taneli; Lehtimaki, Kimmo K.; Svedberg, Marie M.; Haggkvist, Jenny; Tari, Lenke; Toth, Miklos; Varrone, Andrea; Halldin, Christer; Kudwa, Andrea E.; Ramboz, Sylvie; Day, Michelle; Kondapalli, Jyothisri; Surmeier, D. James; Urnov, Fyodor D.; Gregory, Philip D.; Rebar, Edward J.; Munoz-Sanjuan, Ignacio; Zhang, H. Steve 分享 收藏
Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets Conway, Anthony; Mendel, Matthew; Kim, Kenneth; McGovern, Kyle; Boyko, Alisa; Zhang, Lei; Miller, Jeffrey C.; DeKelver, Russell C.; Paschon, David E.; Mui, Barbara L.; Lin, Paulo J. C.; Tam, Ying K.; Barbosa, Chris; Redelmeier, Tom; Holmes, Michael C.; Lee, Gary 分享 收藏
Diversifying the structure of zinc finger nucleases for high-precision genome editing Paschon, David E.; Lussier, Stephanie; Wangzor, Tenzin; Xia, Danny F.; Li, Patrick W.; Hinkley, Sarah J.; Scarlott, Nicholas A.; Lam, Stephen C.; Waite, Adam J.; Truong, Lynn N.; Gandhi, Nimisha; Kadam, Bhakti N.; Patil, Deepak P.; Shivak, David A.; Lee, Gary K.; Holmes, Michael C.; Zhang, Lei; Miller, Jeffrey C.; Rebar, Edward J. 分享 收藏
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DRUG DISCOVERY APPROACH FOR RARE NEUROLOGICAL DISEASES: USING NOVEL ZINC FINGER PROTEIN TECHNOLOGY TO DEVELOP POTENTIAL THERAPY FOR HUNTINGTON'S DISEASE Chiocco, Matthew; Choi, Vivian; Graham, Anne-Renee; Klatte, Debra; Francone, Omar; Thomson, David; Zeitler, Bryan; Froelich, Steven; Yu, Qi; Paschon, David E.; Miller, Jeffrey C.; Marlen, Kimberly; Rebar, Edward J.; Urnov, Fyodor D.; Gregory, Philip D.; Zhang, H. Steve 分享 收藏
Highly Efficient, ZFN-Driven Knockout of Surface Expression of the T-Cell Receptor and HLA Class I Proteins in Human T-Cells for Enhancing Allogeneic Adoptive Cell Therapies Lee, Gary K.; Liu, Pei-qi; Gandhi, Nimisha; Truong, Lynn; Reik, Andreas; Lam, Stephen; Hinkley, Sarah J.; Miller, Jeffrey C.; Paschon, David E.; Zhang, Lei; Rebar, Edward J.; Holmes, Michael C. 分享 收藏
First exploration of parasitoids of Drosophila suzukii in South Korea as potential classical biological agents 韩国果蝇suzukii的寄生虫作为潜在的经典生物制剂的首次探索 Daane, Kent M.; Wang, Xin-Geng; Biondi, Antonio; Miller, Betsey; Miller, Jeffrey C.; Riedl, Helmut; Shearer, Peter W.; Guerrieri, Emilio; Giorgini, Massimo; Buffington, Matthew; van Achterberg, Kees; Song, Yoohan; Kang, Taegun; Yi, Hoonbok; Jung, Chuleui; Lee, Dong Woon; Chung, Bu-Keun; Hoelmer, Kim A.; Walton, Vaughn M. 分享 收藏
Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing Oakes, Benjamin L.; Xia, Danny F.; Rowland, Elizabeth F.; Xu, Denise J.; Ankoudinova, Irina; Borchardt, Jennifer S.; Zhang, Lei; Li, Patrick; Miller, Jeffrey C.; Rebar, Edward J.; Noyes, Marcus B. 分享 收藏
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From GWAS To the Clinic: Genome-Editing the Human BCL11A Erythroid Enhancer for Fetal Globin Elevation in the Hemoglobinopathies Reik, Andreas; Chang, Kai-Hsin; Vierstra, Jeff; Psatha, Nikoletta; Stehling-Sun, Sandra; Zhou, Yuanyue; O'Neil, Colleen M.; Mich, Andrea; Miller, Jeffrey C.; Lee, Gary; Tan, Siyuan; Jiang, Haiyan; Stamatoyannopoulos, George; Papayannopoulou, Thalia; Rebar, Edward J.; Gregory, Philip D.; Stamatoyannopoulos, John A.; Urnov, Fyodor D. 分享 收藏
Host stage preference, efficacy and fecundity of parasitoids attacking Drosophila suzukii in newly invaded areas 在新入侵地区攻击果蝇的寄主阶段偏好，功效和繁殖力 Stacconi, M. Valerio Rossi; Buffington, Matt; Daane, Kent M.; Dalton, Daniel T.; Grassi, Alberto; Kacar, Guelay; Miller, Betsey; Miller, Jeffrey C.; Baser, Nuray; Ioriatti, Claudio; Walton, Vaughn M.; Wiman, Nik G.; Wang, Xingeng; Anfora, Gianfranco 分享 收藏
Improved specificity of TALE-based genome editing using an expanded RVD repertoire 使用扩展的RVD库提高了基于TALE的基因组编辑的特异性 Miller, Jeffrey C.; Zhang, Lei; Xia, Danny F.; Campo, John J.; Ankoudinova, Irina V.; Guschin, Dmitry Y.; Babiarz, Joshua E.; Meng, Xiangdong; Hinkley, Sarah J.; Lam, Stephen C.; Paschon, David E.; Vincent, Anna I.; Dulay, Gladys P.; Barlow, Kyle A.; Shivak, David A.; Leung, Elo; Kim, Jinwon D.; Amora, Rainier; Urnov, Fyodor D.; Gregory, Philip D.; Rebarsimplicity, Edward J. 分享 收藏
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Transcriptional activation of Brassica napusß-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor Gupta, Manju; DeKelver, Russell C.; Palta, Asha; Clifford, Carla; Gopalan, Sunita; Miller, Jeffrey C.; Novak, Stephen; Desloover, Daniel; Gachotte, Daniel; Connell, James; Flook, Josh; Patterson, Thomas; Robbins, Kelly; Rebar, Edward J.; Gregory, Philip D.; Urnov, Fyodor D.; Petolino, Joseph F. 分享 收藏
Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme Wang, Jianbin; Friedman, Geoffrey; Doyon, Yannick; Wang, Nathaniel S.; Li, Carrie Jiaxin; Miller, Jeffrey C.; Hua, Kevin L.; Yan, Jenny Jiacheng; Babiarz, Joshua E.; Gregory, Philip D.; Holmes, Michael C. 分享 收藏
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