John D. Pediani - Publications, H-index & Citations

John D. Pediani

university of glasgow

31H指数

79论文数

2.7K被引数

收录论文 39

发表时间

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells 使用PROTAC选择性降解PDE4B短型，可抑制HCT116细胞中的多种癌症标志物

British Journal of Pharmacology

IF7.7

2026-07-29

OAAI

Alina Zorn; John Daniel Pediani; Madihah Hussain; Jiayue Ling; Elaine Brown; Igor Belka; Eduardo Torres; Cathy Swindlehurst; Kyle Chan; David Stirling; George S. Baillie; Yuan Yan Sin

The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-06-07

OAAI

Marsango, Sara; Jenkins, Laura; Pediani, John D.; Bradley, Sophie J.; Ward, Richard J.; Hesse, Sarah; Biener, Gabriel; Stoneman, Michael R.; Tobin, Andrew B.; Raicu, Valerica; Milligan, Graeme

Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Ward, Richard J.; Pediani, John D.; Marsango, Sara; Jolly, Richard; Stoneman, Michael R.; Biener, Gabriel; Handel, Tracy M.; Raicu, Valerica; Milligan, Graeme

A general method to quantify ligand-driven oligomerization from fluorescence-based images

NATURE METHODS

IF32.1

2019-05-20

OAAI

Stoneman, Michael R.; Biener, Gabriel; Ward, Richard J.; Pediani, John D.; Badu, Dammar; Eis, Annie; Popa, Ionel; Milligan, Graeme; Raicu, Valerica

Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology

FEBS JOURNAL

IF4.2

2018-05-13

OAAI

Liu, Ying; Zeng, Hong; Pediani, John D.; Ward, Richard J.; Chen, Lu-Yao; Wu, Nan; Ma, Li; Tang, Mei; Yang, Yang; An, Su; Guo, Xiao-Xi; Hao, Qian; Xu, Tian-Rui

Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2018-02-01

OAAI

Pediani, John D.; Ward, Richard J.; Marsango, Sara; Milligan, Graeme

Multiple AMPK activators inhibit L-carnitine uptake in C2C12 skeletal muscle myotubes

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2017-06-01

OAAI

Shaw, Andy; Jeromson, Stewart; Watterson, Kenneth R.; Pediani, John D.; Gallagher, Iain J.; Whalley, Tim; Dreczkowski, Gillian; Brooks, Naomi; Galloway, Stuart D.; Hamilton, D. Lee

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

BIOCHEMICAL JOURNAL

IF4.3

2017-05-24

OAAI

Ward, Richard J.; Pediani, John D.; Harikumar, Kaleeckal G.; Miller, Laurence J.; Milligan, Graeme

A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization

SCIENTIFIC REPORTS

IF3.9

2017-05-18

OAAI

Marsango, Sara; Caltabiano, Gianluigi; Jimemez-Roses, Mireia; Millan, Mark J.; Pediani, John D.; Ward, Richard J.; Milligan, Graeme

Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2016-06-01

OAAI

Pediani, John D.; Ward, Richard J.; Godin, Antoine G.; Marsango, Sara; Milligan, Graeme

Regulation of Oligomeric Organization of the Serotonin 5-Hydroxytryptamine 2C (5-HT2C) Receptor Observed by Spatial Intensity Distribution Analysis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-05-01

OAAI

Ward, Richard J.; Pediani, John D.; Godin, Antoine G.; Milligan, Graeme

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2

BIOCHEMICAL JOURNAL

IF4.3

2014-06-13

PREAI

Zakrys, Linas; Ward, Richard J.; Pediani, John D.; Godin, Antoine G.; Graham, Gerard J.; Milligan, Graeme

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

MOLECULAR PHARMACOLOGY

IF3

2013-11-01

181

OAAI

Hudson, Brian D.; Shimpukade, Bharat; Mackenzie, Amanda E.; Butcher, Adrian J.; Pediani, John D.; Christiansen, Elisabeth; Heathcote, Helen; Tobin, Andrew B.; Ulven, Trond; Milligan, Graeme

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun

CELLULAR SIGNALLING

IF3.7

2012-08-01

OAAI

Wiejak, Jolanta; Dunlop, Julia; Stoyle, Chloe; Lappin, Gillian; McIlroy, Anna; Pediani, John D.; Gao, Shan; Yarwood, Stephen J.

Novel Role for Proteinase-activated Receptor 2 (PAR2) in Membrane Trafficking of Proteinase-activated Receptor 4 (PAR4)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2012-05-01

OAAI

Cunningham, Margaret R.; McIntosh, Kathryn A.; Pediani, John D.; Robben, Joris; Cooke, Alexandra E.; Nilsson, Mary; Gould, Gwyn W.; Mundell, Stuart; Milligan, Graeme; Plevin, Robin

Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1 and OX2 Receptors Identify Slow Kinetics of Agonist Activation

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2012-04-01

OAAI

Xu, Tian-Rui; Ward, Richard J.; Pediani, John D.; Milligan, Graeme

Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2012-03-01

OAAI

Fewou, Simon N.; Rupp, Angie; Nickolay, Lauren E.; Carrick, Kathryn; Greenshields, Kay N.; Pediani, John; Plomp, Jaap J.; Willison, Hugh J.

Developing Chemical Genetic Approaches to Explore G Protein-Coupled Receptor Function: Validation of the Use of a Receptor Activated Solely by Synthetic Ligand (RASSL)

MOLECULAR PHARMACOLOGY

IF3

2011-12-01

OAAI

Alvarez-Curto, Elisa; Prihandoko, Rudi; Tautermann, Christofer S.; Zwier, Jurriaan M.; Pediani, John D.; Lohse, Martin J.; Hoffmann, Carsten; Tobin, Andrew B.; Milligan, Graeme

Heteromultimerization of Cannabinoid CB1 Receptor and Orexin OX1 Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-10-01

OAAI

Ward, Richard J.; Pediani, John D.; Milligan, Graeme

The orexin OX1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands

BIOCHEMICAL JOURNAL

IF4.3

2011-09-14

OAAI

Xu, Tian-Rui; Ward, Richard J.; Pediani, John D.; Milligan, Graeme

研究方向