未登录Discovery of Novel Aminopyrimidines as Selective EP2 Receptor Antagonists
Lyothier, Isabelle; Diethelm, Stefan; Pothier, Julien; Sifferlen, Thierry; Pozzi, Davide; Richard-Bildstein, Sylvia; Siendt, Herve; Fretz, Heinz; Boss, Christoph; Wyder, Lorenza; Jeay, Sebastien; de Kanter, Ruben; Gnerre, Carmela; Lehembre, Francois; Meyer, Dominique S.; Corminboeuf, Olivier .png)
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收藏Discovery of ACT-1002-4271 as a Dual Prostaglandin E2 Receptor 2/Prostaglandin E2 Receptor 4 Antagonist with In Vivo Anti-Tumor EfficacyLyothier, Isabelle; Diethelm, Stefan; Pothier, Julien; Sifferlen, Thierry; Pozzi, Davide; Richard-Bildstein, Sylvia; Siendt, Herve; Fretz, Heinz; Boss, Christoph; Wyder, Lorenza; Jeay, Sebastien; de Kanter, Ruben; Gnerre, Carmela; Lehembre, Francois; Meyer, Dominique S.; Corminboeuf, Olivier 分享 收藏 分享 收藏 Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in ratsBrotschi, Christine; Bolli, Martin H.; Gatfield, John; Roch, Catherine; Sifferlen, Thierry; Treiber, Alexander; Williams, Jodi T.; Boss, Christoph 分享 收藏 分享 收藏 European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in EuropeAli, Amjad; Bauser, Marcus; Bertrand, Sophie; Blackaby, Wesley; Boss, Christoph; Bossart, Martin; Hall, Adrian; Binch, Hayley; Czechtizky, Werngard; Gijsen, Harrie; Haning, Helmut; Hartung, Ingo V.; Kilburn, Paul; Lassalle, Gilbert; Luecking, Ulrich; Mack, Juergen; Missbach, Martin; Otsomaa, Leena; Torrens, Antoni; Wagner, Michael; Walter, Magnus; Weinstabl, Harald; van Hijfte, Luc; von Nussbaum, Franz 分享 收藏 Design, Synthesis, and Optimization of Indole Acetic Acid Derivatives as Potent and Selective CRTH2 Receptor Antagonists: Discovery of ACT-774312Aissaoui, Hamed; Holdener, Martin; Gnerre, Carmela; Niggemann, Kerstin; Reber, Stefan; Richard, Sylvia; Siegrist, Romain; Boss, Christoph 分享 收藏 The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia DisordersBoss, Christoph; Gatfield, John; Brotschi, Christine; Heidmann, Bibia; Sifferlen, Thierry; von Raumer, Markus; Schmidt, Gunther; Williams, Jodi T.; Treiber, Alexander; Roch, Catherine 分享 收藏 From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in DogsBrotschi, Christine; Bolli, Martin H.; Gatfield, John; Heidmann, Bibia; Jenck, Francois; Roch, Catherine; Sifferlen, Thierry; Treiber, Alexander; Williams, Jodi T.; Boss, Christoph 分享 收藏 Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in RatsBrotschi, Christine; Roch, Catherine; Gatfield, John; Treiber, Alexander; Williams, Jodi T.; Sifferlen, Thierry; Heidmann, Bibia; Jenck, Francois; Bolli, Martin H.; Boss, Christoph 分享 收藏 The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468Treiber, Alexander; de Kanter, Ruben; Roch, Catherine; Gatfield, John; Boss, Christoph; von Raumer, Markus; Schindelholz, Benno; Muehlan, Clemens; van Gerven, Joop; Jenck, Francois 分享 收藏 分享 收藏 Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of ActionBoss, Christoph; Aissaoui, Hamed; Amaral, Nathalie; Bauer, Aude; Bazire, Stephanie; Binkert, Christoph; Brun, Reto; Burki, Cedric; Ciana, Claire-Lise; Corminboeuf, Olivier; Delahaye, Stephane; Dollinger, Claire; Fischli, Christoph; Fischli, Walter; Flock, Alexandre; Frantz, Marie-Celine; Girault, Malory; Grisostomi, Corinna; Friedli, Astrid; Heidmann, Bibia; Hinder, Claire; Jacob, Gael; Le Bihan, Amelie; Malrieu, Sophie; Mamzed, Saskia; Merot, Aurelien; Meyer, Solange; Peixoto, Sabrina; Petit, Nolwenn; Siegrist, Romain; Trollux, Julien; Weller, Thomas; Wittlin, Sergio 分享 收藏 Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping ApproachHeidmann, Bibia; Gatfield, John; Roch, Catherine; Treiber, Alexander; Tortoioli, Simone; Brotschi, Christine; Williams, Jodi T.; Bolli, Martin H.; Abele, Stefan; Sifferlen, Thierry; Jenck, Francois; Boss, Christoph 分享 收藏 分享 收藏 分享 收藏 Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor AntagonistBoss, Christoph; Roch-Brisbare, Catherine; Steiner, Michel A.; Treiber, Alexander; Dietrich, Hendrik; Jenck, Francois; von Raumer, Markus; Sifferlen, Thierry; Brotschi, Christine; Heidmann, Bibia; Williams, Jodi T.; Aissaoui, Hamed; Siegrist, Romain; Gatfield, John 分享 收藏 分享 收藏 UV-triggered Affinity Capture Identifies Interactions between the Plasmodium falciparum Multidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized CellsBrunner, Ralf; Ng, Caroline L.; Aissaoui, Hamed; Akabas, Myles H.; Boss, Christoph; Brun, Reto; Callaghan, Paul S.; Corminboeuf, Olivier; Fidock, David A.; Frame, Ithiel J.; Heidmann, Bibia; Le Bihan, Amelie; Jenoe, Paul; Mattheis, Corinna; Moes, Suzette; Mueller, Ingrid B.; Paguio, Michelle; Roepe, Paul D.; Siegrist, Romain; Voss, Till; Welford, Richard W. D.; Wittlin, Sergio; Binkert, Christoph 分享 收藏 分享 收藏 
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