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A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses Van Loy, Benjamin; Pujol, Eugenia; Kamata, Kenichi; Lee, Xiao Yin; Bakirtzoglou, Nikolai; Van Berwaer, Ria; Vandeput, Julie; Mestdagh, Cato; Persoons, Leentje; De Wijngaert, Brent; Goovaerts, Quinten; Noppen, Sam; Jacquemyn, Maarten; Ahmadzadeh, Kourosh; Bernaerts, Eline; Martin-Lopez, Juan; Escriche, Celia; Vanmechelen, Bert; Krasniqi, Besir; Singh, Abhimanyu K.; Daelemans, Dirk; Maes, Piet; Matthys, Patrick; Dehaen, Wim; Rozenski, Jef; Das, Kalyan; Voet, Arnout; Vazquez, Santiago; Naesens, Lieve; Stevaert, Annelies 分享 收藏
The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity Blaazer, Antoni R.; Singh, Abhimanyu K.; Zara, Lorena; Boronat, Pierre; Bautista, Lady J.; Irving, Steve; Majewski, Maciej; Barril, Xavier; Wijtmans, Maikel; Danielson, U. Helena; Sterk, Geert Jan; Leurs, Rob; van Muijlwijk-Koezen, Jacqueline E.; Brown, David G.; de Esch, Iwan J. P. 分享 收藏
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine Singh, Abhimanyu K.; De Wijngaert, Brent; Bijnens, Marc; Uyttersprot, Kris; Nguyen, Hoai; Martinez, Sergio E.; Schols, Dominique; Herdewijn, Piet; Pannecouque, Christophe; Arnold, Eddy; Das, Kalyan 分享 收藏
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Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation Cowell, Alana R.; Jacquemet, Guillaume; Singh, Abhimanyu K.; Varela, Lorena; Nylund, Anna S.; Ammon, York-Christoph; Brown, David G.; Akhmanova, Anna; Ivaska, Johanna; Goult, Benjamin T. 分享 收藏
Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds Salado, Irene G.; Singh, Abhimanyu K.; Moreno-Cinos, Carlos; Sakaine, Guna; Siderius, Marco; Van der Veken, Pieter; Matheeussen, An; van der Meer, Tiffany; Sadek, Payman; Gul, Sheraz; Maes, Louis; Sterk, Geert-Jan; Leurs, Rob; Brown, David; Augustyns, Koen 分享 收藏
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors de Heuvel, Erik; Singh, Abhimanyu K.; Edink, Ewald; van der Meer, Tiffany; van der Woude, Melanie; Sadek, Payman; Krell-Jorgensen, Mikkel P.; van den Bergh, Toine; Veerman, Johan; Caljon, Guy; Kalejaiye, Titilola D.; Wijtmans, Maikel; Maes, Louis; de Koning, Harry P.; Sterk, Geert Jan; Siderius, Marco; de Esch, Iwan J. P.; Brown, David G.; Leurs, Rob 分享 收藏
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2) de Heuvel, Erik; Singh, Abhimanyu K.; Boronat, Pierre; Kooistra, Albert J.; van der Meer, Tiffany; Sadek, Payman; Blaazer, Antoni R.; Shaner, Nathan C.; Bindels, Daphne S.; Caljon, Guy; Maes, Louis; Sterk, Geert Jan; Siderius, Marco; Oberholzer, Michael; de Esch, Iwan J. P.; Brown, David G.; Leurs, Rob 分享 收藏
Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre Singh, Abhimanyu K.; Nguyen, Thanh H.; Vidovszky, Marton Z.; Harrach, Balazs; Benko, Maria; Kirwan, Alan; Joshi, Lokesh; Kilcoyne, Michelle; Alvaro Berbis, M.; Javier Canada, F.; Jimenez-Barbero, Jesus; Menendez, Margarita; Wilson, Sarah S.; Bromme, Beth A.; Smith, Jason G.; van Raaij, Mark J. 分享 收藏
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Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity Blaazer, Antoni R.; Singh, Abhimanyu K.; de Heuvel, Erik; Edink, Ewald; Orrling, Kristina M.; Veerman, Johan J. N.; van den Bergh, Toine; Jansen, Chimed; Balasubramaniam, Erin; Mooij, Wouter J.; Custers, Hans; Sijm, Maarten; Tagoe, Daniel N. A.; Kalejaiye, Titilola D.; Munday, Jane C.; Tenor, Hermann; Matheeussen, An; Wijtmans, Maikel; Siderius, Marco; de Graaf, Chris; Maes, Louis; de Koning, Harry P.; Bailey, David S.; Sterk, Geert Jan; de Esch, Iwan J. P.; Brown, David G.; Leurs, Rob 分享 收藏
Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016) Kryshtafovych, Andriy; Albrecht, Reinhard; Basle, Arnaud; Bule, Pedro; Caputo, Alessandro T.; Carvalho, Ana Luisa; Chao, Kinlin L.; Diskin, Ron; Fidelis, Krzysztof; Fontes, Carlos M. G. A.; Fredslund, Folmer; Gilbert, Harry J.; Goulding, Celia W.; Hartmann, Marcus D.; Hayes, Christopher S.; Herzberg, Osnat; Hill, Johan C.; Joachimiak, Andrzej; Kohring, Gert-Wieland; Koning, Roman I.; Lo Leggio, Leila; Mangiagalli, Marco; Michalska, Karolina; Moult, John; Najmudin, Shabir; Nardini, Marco; Nardone, Valentina; Ndeh, Didier; Thanh-Hong Nguyen; Pintacuda, Guido; Postel, Sandra; van Raaij, Mark J.; Roversi, Pietro; Shimon, Amir; Singh, Abhimanyu K.; Sundberg, Eric J.; Tars, Kaspars; Zitzmann, Nicole; Schwede, Torsten 分享 收藏
Some of the most interesting CASP11 targets through the eyes of their authors Kryshtafovych, Andriy; Moult, John; Basle, Arnaud; Burgin, Alex; Craig, Timothy K.; Edwards, Robert A.; Fass, Deborah; Hartmann, Marcus D.; Korycinski, Mateusz; Lewis, Richard J.; Lorimer, Donald; Lupas, Andrei N.; Newman, Janet; Peat, Thomas S.; Piepenbrink, Kurt H.; Prahlad, Janani; van Raaij, Mark J.; Rohwer, Forest; Segall, Anca M.; Seguritan, Victor; Sundberg, Eric J.; Singh, Abhimanyu K.; Wilson, Mark A.; Schwede, Torsten 分享 收藏
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Discovery of novel methanone derivatives acting as antimycobacterial agents Ali, Mohamed Ashraf; Bastian, Sylvaine; Ismail, Rusli; Choon, Tan Soo; Ali, Sadath; Aubry, Alexandra; Pandian, Suresh; Saraswat, Pankaj; Singh, Abhimanyu; Gaur, Ramakant 分享 收藏
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