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Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche 组蛋白甲基转移酶ASH1L促进骨微环境中巨噬细胞转移和代谢重编程 Meng, Chenling; Lin, Kevin; Shi, Wei; Teng, Hongqi; Wan, Xinhai; Debruine, Anna; Wang, Yin; Liang, Xin; Leo, Javier; Chen, Feiyu; Gu, Qianlin; Zhang, Jie; Van, Vivien; Maldonado, Kiersten L.; Gan, Boyi; Lu, Yue; Zhao, Di 分享 收藏
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors CHD1缺失重编程SREBP2驱动的胆固醇合成，以支持雄激素应答性生长和去势抵抗在SPOP突变的前列腺肿瘤中。 Chen, Feiyu; Li, Haoyan; Wang, Yin; Tang, Ximing; Lin, Kevin; Li, Qidong; Meng, Chenling; Shi, Wei; Leo, Javier; Liang, Xin; Zhang, Jie; Van, Vivien; Mahmud, Iqbal; Wei, Bo; Lorenzi, Philip L.; Raso, Maria G.; Aparicio, Ana; Lu, Yue; Frigo, Daniel E.; Gan, Boyi 分享 收藏
Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation ASH1L与组蛋白H3K36和H3K4甲基化的构效关系 Vann, Kendra R.; Sharma, Rajal; Hsu, Chih-Chao; Devoucoux, Maeva; Tencer, Adam H.; Zeng, Lei; Lin, Kevin; Zhu, Li; Li, Qin; Lachance, Catherine; Ospina, Ruben Rosas; Tong, Qiong; Cheung, Ka Lung; Yang, Shuai; Biswas, Soumi; Xuan, Hongwen; Gatchalian, Jovylyn; Alamillo, Lorena; Jang, Suk Min; Klein, Brianna J.; Lu, Yue; Ernst, Patricia; Strahl, Brian D.; Rothbart, Scott B.; Walsh, Martin J.; Cleary, Michael L.; Shi, Xiaobing; Zhou, Ming-Ming; Kutateladze, Tatiana G. 分享 收藏
Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins 肿瘤细胞通过脂肪酸结合蛋白避免免疫细胞诱导的铁死亡。 Freitas-Cortez, Maria Angelica; Masrorpour, Fatemeh; Jiang, Hong; Mahmud, Iqbal; Lu, Yue; Huang, Ailing; Duong, Lisa K.; Wang, Qi; Voss, Tiffany A.; Leyton, Claudia S. Kettlun; Wei, Bo; Chan, Wai-Kin; Lin, Kevin; Zhang, Jie; Tsouko, Efrosini; Ganjoo, Shonik; Barsoumian, Hampartsoum B.; Riad, Thomas S.; Hu, Yun; Leuschner, Carola; Puebla-Osorio, Nahum; Wang, Jing; Hu, Jian; Davies, Michael A.; Puduvalli, Vinay K.; Billon, Cyrielle; Burris, Thomas P.; Lorenzi, Philip L.; Gan, Boyi; Welsh, James W. 分享 收藏
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate 规范雄激素反应元件基序是前列腺中的肿瘤抑制调节元件 Chen, Xuanrong; Augello, Michael A.; Liu, Deli; Lin, Kevin; Hakansson, Alex; Sjostrom, Martin; Khani, Francesca; Deonarine, Lesa D.; Liu, Yang; Travascio-Green, Jaida; Wu, Jiansheng; Chan, Un In; Owiredu, Jude; Loda, Massimo; Feng, Felix Y.; Robinson, Brian D.; Davicioni, Elai; Sboner, Andrea; Barbieri, Christopher E. 分享 收藏
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LODESTAR: A Single Arm Phase II Study of Rucaparib in Solid Tumors with Pathogenic Germline or Somatic Variants in Homologous Recombination Repair (HRR) Genes Anbil, Sriram; Seewald, Nicholas J.; Lin, Kevin; Craib, Marcia; Connor, Christy; Giordano, Heidi; McLachlan, Karen; Kwan, Tanya; Maloney, Lara; Tukachinsky, Hanna; Schrock, Alexa; Wang, Shuoguo; Sokol, Ethan; Decker, Brennan; Nathanson, Katherine; Domchek, Susan; Reiss, Kim 分享 收藏
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BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance Nesic, Ksenija; Krais, John J.; Wang, Yifan; Vandenberg, Cassandra J.; Patel, Pooja; Cai, Kathy Q.; Kwan, Tanya; Lieschke, Elizabeth; Ho, Gwo-Yaw; Barker, Holly E.; Bedo, Justin; Casadei, Silvia; Farrell, Andrew; Radke, Marc; Shield-Artin, Kristy; Penington, Jocelyn S.; Geissler, Franziska; Kyran, Elizabeth; Betsch, Robert; Xu, Lijun; Zhang, Fan; Dobrovic, Alexander; Olesen, Inger; Kristeleit, Rebecca; Oza, Amit; McNeish, Iain; Ratnayake, Gayanie; Traficante, Nadia; DeFazio, Anna; Bowtell, David D. L.; Harding, Thomas C.; Lin, Kevin; Swisher, Elizabeth M.; Kondrashova, Olga; Scott, Clare L.; Johnson, Neil; Wakefield, Matthew J. 分享 收藏
Targeting a lineage-specific PI3Kγ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule 使用异双功能降解剂分子靶向急性髓性白血病中的谱系特异性PI3Kγ-Akt信号模块 Kelly, Lois M.; Rutter, Justine C.; Lin, Kevin H.; Ling, Frank; Duchmann, Matthieu; Latour, Emmanuelle; Arang, Nadia; Pasquer, Helene; Nhat, Duong Ho; Charles, Juliette; Killarney, Shane T.; Ang, Hazel X.; Namor, Federica; Culeux, Cecile; Lombard, Berangere; Loew, Damarys; Swaney, Danielle L.; Krogan, Nevan J.; Brunel, Luc; Carretero, Elodie; Verdie, Pascal; Amblard, Muriel; Fodil, Sofiane; Huynh, Tony; Sebert, Marie; Ades, Lionel; Raffoux, Emmanuel; Fenouille, Nina; Itzykson, Raphael; Lobry, Camille; Benajiba, Lina; Forget, Antoine; Martin, Anthony R.; Wood, Kris C.; Puissant, Alexandre 分享 收藏
PitViper: a software for comparative meta-analysis and annotation of functional screening data Meslin, Paul-Arthur; Kelly, Lois M.; Benbarche, Salima; Lecourt, Severine; Lin, Kevin H.; Rutter, Justine C.; Bassil, Christopher F.; Itzykson, Raphael; Wood, Kris C.; Puissant, Alexandre; Lobry, Camille 分享 收藏
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Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells Liu, Shengjiang; Li, Jinzhong; Peraramelli, Sameera; Luo, Ningguang; Chen, Alan; Dai, Minghua; Liu, Fang; Yu, Yanbao; Leib, Ryan D.; Li, Ying; Lin, Kevin; Huynh, Derrick; Li, Shuyi; Ou, Li 分享 收藏
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Integration of spatial and single-cell data across modalities with weakly linked features Chen, Shuxiao; Zhu, Bokai; Huang, Sijia; Hickey, John W.; Lin, Kevin Z.; Snyder, Michael; Greenleaf, William J.; Nolan, Garry P.; Zhang, Nancy R.; Ma, Zongming 分享 收藏
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer PI3K/AKT/mTOR信号转导通路与肿瘤靶向治疗 Glaviano, Antonino; Foo, Aaron S. C.; Lam, Hiu Y.; Yap, Kenneth C. H.; Jacot, William; Jones, Robert H.; Eng, Huiyan; Nair, Madhumathy G.; Makvandi, Pooyan; Geoerger, Birgit; Kulke, Matthew H.; Baird, Richard D.; Prabhu, Jyothi S.; Carbone, Daniela; Pecoraro, Camilla; Teh, Daniel B. L.; Sethi, Gautam; Cavalieri, Vincenzo; Lin, Kevin H.; Javidi-Sharifi, Nathalie R.; Toska, Eneda; Davids, Matthew S.; Brown, Jennifer R.; Diana, Patrizia; Stebbing, Justin; Fruman, David A.; Kumar, Alan P. 分享 收藏
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