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L

Luke A. Masterson

AstraZeneca
H指数:21
被引数:1,769

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Engineered Ultrasmall Nanoparticle Drug-Immune Conjugates with Hit and Run Tumor Delivery to Eradicate Gastric Cancer

具有命中和运行肿瘤递送的工程化超小纳米颗粒药物免疫缀合物根除胃癌

ADVANCED THERAPEUTICS
IF2.6
2022-11-146
OA
Zhang, Li; Aragon-Sanabria, Virginia; Aditya, Anusha; Marelli, Marcello; Cao, Tianye; Chen, Feng; Yoo, Barney; Ma, Kai; Zhuang, Li; Cailleau, Thais; Masterson, Luke; Turker, Melik Z.; Lee, Rachel; DeLeon, Gabriel; Monette, Sebastien; Colombo, Raffaele; Christie, Ronald J.; Zanzonico, Pat; Wiesner, Ulrich; Subramony, J. Anand; Bradbury, Michelle S.
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305
CLINICAL CANCER RESEARCH
IF10.2
2022-11-1030
OA
Kinneer, Krista; Wortmann, Philipp; Cooper, Zachary A.; Dickinson, Niall J.; Masterson, Luke; Cailleau, Thais; Hutchinson, Ian; Vijayakrishnan, Balakumar; McFarlane, Mary; Ball, Kathryn; Davies, Michael; Lewis, Arthur; Huang, Yue; Rosenbaum, Anton I.; Yuan, Jiaqi; Chesebrough, Jon; Anderton, Judith; Monks, Noel; Novick, Steven; Wang, Jixin; Dimasi, Nazzareno; Christie, R. James; Sabol, Darrin; Tosto, Frances Anne; Wallez, Yann; Leo, Elisabetta; Albertella, Mark R.; Staniszewska, Anna D.; Tice, David A.; Howard, Philip W.; Luheshi, Nadia; Sapra, Puja
Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-07-066
OA
Gregson, Stephen J.; Pugh, Kathryn; Patel, Neki; Afif-Rider, Shameen; Vijayakrishnan, Balakumar; Santos, Kathleen; Riedl, Jitka; Hutchinson, Ian; Kang, Gyoung-Dong; Chooi, K. Phin; Beard, Rhiannon; Adams, Lauren; Barry, Conor S.; Ball, Kathryn; Masterson, Luke A.; McFarlane, Mary; Hartley, John A.; Howard, Philip W.
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-03-0221
OA
Mao, Shenlan; Chaerkady, Raghothama; Yu, Wen; D'Angelo, Gina; Garcia, Andrew; Chen, Hong; Barrett, Allison M.; Phipps, Sandrina; Fleming, Ryan; Hess, Sonja; Koopmann, Jens-Oliver; Dimasi, Nazzareno; Wilson, Susan; Pugh, Kathryn; Cook, Kimberly; Masterson, Luke A.; Gao, Changshou; Wu, Herren; Herbst, Ronald; Howard, Philip W.; Tice, David A.; Cobbold, Mark; Harper, Jay
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
SCIENTIFIC REPORTS
IF3.9
2018-07-1195
OAAI
Hartley, John A.; Flynn, Michael J.; Bingham, John P.; Corbett, Simon; Reinert, Halla; Tiberghien, Arnaud; Masterson, Luke A.; Antonow, Dyeison; Adams, Lauren; Chowdhury, Sajidah; Williams, David G.; Mao, Shenlan; Harper, Jay; Havenith, Carin E. G.; Zammarchi, Francesca; Chivers, Simon; van Berkel, Patrick H.; Howard, Philip W.
Loss of the lysosomal transporter SLC46A3 is a mechanism for innate and acquired resistance to non-cleavable maytansine and pyrrolobenzodiazepine-based antibody-drug conjugates
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-01-010
PRE
Kinneer, Krista; Meekin, John; Phipps, Sandrina; Bezabeh, Binyam; Fleming, Ryan; Kiefer, Christine; Rebelatto, Marlon; Dimasi, Nazzareno; Wick, Michael J.; Moriarty, Alyssa; Groves, Megan; Herbst, Ronald; Tiberghien, Arnaud; Masterson, Luke; Howard, Philip; Tice, David
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-12-2171
PREAI
Wei, BinQing; Gunzner-Toste, Janet; Yao, Hui; Wang, Tao; Wang, Jing; Xu, Zijin; Chen, Jinhua; Wai, John; Nonomiya, Jim; Tsai, Siao Ping; Chuh, Josefa; Kozak, Katherine R.; Liu, Yichin; Yu, Shang-Fan; Lau, Jeff; Li, Guangmin; Phillips, Gail D.; Leipold, Doug; Kamath, Amrita; Su, Dian; Xu, Keyang; Eigenbrot, Charles; Steinbacher, Stefan; Ohri, Rachana; Raab, Helga; Staben, Leanna R.; Zhao, Guiling; Flygare, John A.; Pillow, Thomas H.; Verma, Vishal; Masterson, Luke A.; Howard, Philip W.; Safina, Brian
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-11-1631
PREAI
Gregson, Stephen J.; Masterson, Luke A.; Wei, Binqing; Pillow, Thomas H.; Spencer, Susan D.; Kang, Gyoung-Dong; Yu, Shang -Fan; Raab, Helga; Lau, Jeffrey; Li, Guangmin; Phillips, Gail D. Lewis; Gunner-Toste, Janet; Safina, Brian S.; Ohri, Rachana; Darwish, Martine; Kozak, Katherine R.; dela Cruz-Chuh, Josefa; Poison, Andrew; Flygare, John A.; Howard, Philip W.
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers
MOLECULAR CANCER THERAPEUTICS
IF5.5
2017-05-0260
OAAI
Pillow, Thomas H.; Schutten, Melissa; Yu, Shang-Fan; Ohri, Rachana; Sadowsky, Jack; Poon, Kirsten Achilles; Solis, Willy; Zhong, Fiona; Del Rosario, Geoffrey; Go, Mary Ann T.; Lau, Jeffrey; Yee, Sharon; He, Jintang; Liu, Luna; Ng, Carl; Xu, Keyang; Leipold, Douglas D.; Kamath, Amrita V.; Zhang, Donglu; Masterson, Luke; Gregson, Stephen J.; Howard, Philip W.; Fang, Fan; Chen, Jinhua; Gunzner-Toste, Janet; Kozak, Katherine K.; Spencer, Susan; Polakis, Paul; Polson, Andrew G.; Flygare, John A.; Junutula, Jagath R.
ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
MOLECULAR CANCER THERAPEUTICS
IF5.5
2016-11-01103
OAAI
Flynn, Michael J.; Zammarchi, Francesca; Tyrer, Peter C.; Akarca, Ayse U.; Janghra, Narinder; Britten, Charles E.; Havenith, Carin E. G.; Levy, Jean-Noel; Tiberghien, Arnaud; Masterson, Luke A.; Barry, Conor; D'Hooge, Francois; Marafioti, Teresa; Parren, Paul W. H. I.; Williams, David G.; Howard, Philip W.; van Berkel, Patrick H.; Hartley, John A.

研究方向

暂未获取到该数据
P
Philip W. Howard
H 指数:35论文数:220被引数:4,391
J
John A. Hartley
H 指数:75论文数:506被引数:2.6万
A
Arnaud Tiberghien
H 指数:19论文数:83被引数:1,577
N
Nazzareno Dimasi
H 指数:33论文数:152被引数:3,691
S
Stephen J. Gregson
H 指数:19论文数:63被引数:1,362
F
Francesca Zammarchi
H 指数:16论文数:134被引数:1,380
P
Patrick H. van Berkel
H 指数:13论文数:137被引数:858
P
Philip W. Howard
H 指数:12论文数:24被引数:732
R
Ryan Fleming
H 指数:21论文数:121被引数:2,036
L
Lauren Adams
H 指数:11论文数:44被引数:732