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P

Philip W. Howard

AstraZeneca
H指数:35
被引数:4,391
浏览量:0

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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-12-023
OA
Tiberghien, Arnaud C.; Vijayakrishnan, Balakumar; Esfandiari, Arman; Ahmed, Mahammad; Pardo, Raul; Bingham, John; Adams, Lauren; Santos, Kathleen; Kang, Gyoung-Dong; Pugh, Kathryn M.; Afif-Rider, Shameen; Vashisht, Kapil; Haque, Kemal; Tammali, Ravinder; Rosfjord, Edward; Savoca, Adriana; Hartley, John A.; Howard, Philip W.
Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-07-066
OA
Gregson, Stephen J.; Pugh, Kathryn; Patel, Neki; Afif-Rider, Shameen; Vijayakrishnan, Balakumar; Santos, Kathleen; Riedl, Jitka; Hutchinson, Ian; Kang, Gyoung-Dong; Chooi, K. Phin; Beard, Rhiannon; Adams, Lauren; Barry, Conor S.; Ball, Kathryn; Masterson, Luke A.; McFarlane, Mary; Hartley, John A.; Howard, Philip W.
Simultaneous monitoring of multiple attributes of pyrrolobenzodiazepine antibody-drug conjugates by size exclusion chromatography - high resolution mass spectrometry

通过尺寸排阻色谱-高分辨率质谱法同时监测吡咯并苯并二氮杂抗体-药物结合物的多种属性

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
IF3.1
2021-10-016
OAAI
Fussl, Florian; Barry, Conor S.; Pugh, Kathryn M.; Chooi, K. Phin; Vijayakrishnan, Balakumar; Kang, Gyoung-Dong; von Bulow, Christina; Howard, Philip W.; Bones, Jonathan
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR
MOLECULAR CANCER THERAPEUTICS
IF5.5
2021-03-0221
OA
Mao, Shenlan; Chaerkady, Raghothama; Yu, Wen; D'Angelo, Gina; Garcia, Andrew; Chen, Hong; Barrett, Allison M.; Phipps, Sandrina; Fleming, Ryan; Hess, Sonja; Koopmann, Jens-Oliver; Dimasi, Nazzareno; Wilson, Susan; Pugh, Kathryn; Cook, Kimberly; Masterson, Luke A.; Gao, Changshou; Wu, Herren; Herbst, Ronald; Howard, Philip W.; Tice, David A.; Cobbold, Mark; Harper, Jay
TR1801-ADC: a highly potent cMet antibody-drug conjugate with high activity in patient-derived xenograft models of solid tumors
MOLECULAR ONCOLOGY
IF4.5
2019-12-0350
OA
Gymnopoulos, Marco; Betancourt, Oscar; Blot, Vincent; Fujita, Ryo; Galvan, Diana; Lieuw, Vincent; Nguyen, Sophie; Snedden, Jeanette; Stewart, Christine; Villicana, Jose; Wojciak, Jon; Wong, Eley; Pardo, Raul; Patel, Neki; D'Hooge, Francois; Vijayakrishnan, Balakumar; Barry, Conor; Hartley, John A.; Howard, Philip W.; Newman, Roland; Coronella, Julia
A Reactive Antibody Platform for One-Step Production of Antibody-Drug Conjugates through a Diels-Alder Reaction with Maleimide
BIOCONJUGATE CHEMISTRY
IF3.9
2019-08-0526
PREAI
St Arriant, Andre H.; Huang, Fengying; Lin, Jia; Lemen, Daniel; Chakiath, Chacko; Mao, Shenlan; Fazenbaker, Christine; Zhong, Haihong; Harper, Jay; Xu, Wenshu; Patel, Neki; Adams, Lauren; Vijayakrishnan, Balakumar; Howard, Philip W.; Marelli, Marcello; Wu, Herren; Gao, Changshou; de Alaniz, Javier Read; Christie, R. James
Preclinical assessment of an antibody-PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells
LEUKEMIA
IF13.4
2018-10-1251
PREAI
Kinneer, Krista; Flynn, Matt; Thomas, Suneetha B.; Meekin, John; Varkey, Reena; Xiao, Xiaodong; Zhong, Haihong; Breen, Shannon; Hynes, Paul G.; Fleming, Ryan; Bezabeh, Binyam; Chen, Cui (Tracy); Wetzel, Leslie; Chen, Ruoyan; Dimasi, Nazzareno; Tai, Yu-Tzu; Anderson, Kenneth C.; Herbst, Ronald; Howard, Philip W.; Hurt, Elaine M.; Tice, David A.
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
SCIENTIFIC REPORTS
IF3.9
2018-07-1195
OAAI
Hartley, John A.; Flynn, Michael J.; Bingham, John P.; Corbett, Simon; Reinert, Halla; Tiberghien, Arnaud; Masterson, Luke A.; Antonow, Dyeison; Adams, Lauren; Chowdhury, Sajidah; Williams, David G.; Mao, Shenlan; Harper, Jay; Havenith, Carin E. G.; Zammarchi, Francesca; Chivers, Simon; van Berkel, Patrick H.; Howard, Philip W.
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-11-1631
PREAI
Gregson, Stephen J.; Masterson, Luke A.; Wei, Binqing; Pillow, Thomas H.; Spencer, Susan D.; Kang, Gyoung-Dong; Yu, Shang -Fan; Raab, Helga; Lau, Jeffrey; Li, Guangmin; Phillips, Gail D. Lewis; Gunner-Toste, Janet; Safina, Brian S.; Ohri, Rachana; Darwish, Martine; Kozak, Katherine R.; dela Cruz-Chuh, Josefa; Poison, Andrew; Flygare, John A.; Howard, Philip W.
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers
MOLECULAR CANCER THERAPEUTICS
IF5.5
2017-05-0260
OAAI
Pillow, Thomas H.; Schutten, Melissa; Yu, Shang-Fan; Ohri, Rachana; Sadowsky, Jack; Poon, Kirsten Achilles; Solis, Willy; Zhong, Fiona; Del Rosario, Geoffrey; Go, Mary Ann T.; Lau, Jeffrey; Yee, Sharon; He, Jintang; Liu, Luna; Ng, Carl; Xu, Keyang; Leipold, Douglas D.; Kamath, Amrita V.; Zhang, Donglu; Masterson, Luke; Gregson, Stephen J.; Howard, Philip W.; Fang, Fan; Chen, Jinhua; Gunzner-Toste, Janet; Kozak, Katherine K.; Spencer, Susan; Polakis, Paul; Polson, Andrew G.; Flygare, John A.; Junutula, Jagath R.
ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
MOLECULAR CANCER THERAPEUTICS
IF5.5
2016-11-01103
OAAI
Flynn, Michael J.; Zammarchi, Francesca; Tyrer, Peter C.; Akarca, Ayse U.; Janghra, Narinder; Britten, Charles E.; Havenith, Carin E. G.; Levy, Jean-Noel; Tiberghien, Arnaud; Masterson, Luke A.; Barry, Conor; D'Hooge, Francois; Marafioti, Teresa; Parren, Paul W. H. I.; Williams, David G.; Howard, Philip W.; van Berkel, Patrick H.; Hartley, John A.

研究方向

暂未获取到该数据
J
John A. Hartley
H 指数:75论文数:506被引数:2.6万
D
David E. Thurston
H 指数:45论文数:341被引数:7,111
L
Luke A. Masterson
H 指数:21论文数:114被引数:1,769
S
Stephen J. Gregson
H 指数:19论文数:63被引数:1,362
A
Arnaud Tiberghien
H 指数:19论文数:83被引数:1,577
T
Terence C. Jenkins
H 指数:42论文数:180被引数:6,255
J
Jay Harper
H 指数:23论文数:126被引数:2,061
B
Balakumar Vijayakrishnan
H 指数:14论文数:54被引数:850
C
Changshou Gao
H 指数:33论文数:112被引数:3,998
G
Gyoung‐Dong Kang
H 指数:7论文数:18被引数:150