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A

Arnaud Tiberghien

AstraZeneca
H指数:19
被引数:1,581

个人简介

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工作经历

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荣誉奖项

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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity
MOLECULAR CANCER THERAPEUTICS
IF5.5
2022-12-023
OA
Tiberghien, Arnaud C.; Vijayakrishnan, Balakumar; Esfandiari, Arman; Ahmed, Mahammad; Pardo, Raul; Bingham, John; Adams, Lauren; Santos, Kathleen; Kang, Gyoung-Dong; Pugh, Kathryn M.; Afif-Rider, Shameen; Vashisht, Kapil; Haque, Kemal; Tammali, Ravinder; Rosfjord, Edward; Savoca, Adriana; Hartley, John A.; Howard, Philip W.
Preclinical Characterization of an Antibody-Drug Conjugate Targeting CS-1 and the Identification of Uncharacterized Populations of CS-1-Positive Cells
MOLECULAR CANCER THERAPEUTICS
IF5.5
2020-08-040
OAAI
Chen, Ruoyan; Rajan, Saravanan; Overstreet, Michael G.; Hurt, Elaine M.; Thomas, Suneetha B.; Muniz-Medina, Vanessa; Ward, Christopher; Sadowska, Agnieszka; Fleming, Ryan; Karanth, Subramanya; Breen, Shannon; Zheng, Bo; Wu, Yuling; Iverson, William O.; Novick, Steven; O'Day, Terrence; Shah, Dipesha P.; Dimasi, Nazzareno; Tiberghien, Arnaud C.; Osbourn, Jane; Walker, Jill
SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads
CLINICAL CANCER RESEARCH
IF10.2
2018-12-1360
OAAI
Kinneer, Krista; Meekin, John; Tiberghien, Arnaud C.; Tai, Yu-Tzu; Phipps, Sandrina; Kiefer, Christine Mione; Rebelatto, Marlon C.; Dimasi, Nazzareno; Moriarty, Alyssa; Papadopoulos, Kyriakos P.; Sridhar, Sriram; Gregson, Stephen J.; Wick, Michael J.; Masterson, Luke; Anderson, Kenneth C.; Herbst, Ronald; Howard, Philip W.; Tice, David A.
Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
SCIENTIFIC REPORTS
IF3.9
2018-07-1195
OAAI
Hartley, John A.; Flynn, Michael J.; Bingham, John P.; Corbett, Simon; Reinert, Halla; Tiberghien, Arnaud; Masterson, Luke A.; Antonow, Dyeison; Adams, Lauren; Chowdhury, Sajidah; Williams, David G.; Mao, Shenlan; Harper, Jay; Havenith, Carin E. G.; Zammarchi, Francesca; Chivers, Simon; van Berkel, Patrick H.; Howard, Philip W.
Loss of the lysosomal transporter SLC46A3 is a mechanism for innate and acquired resistance to non-cleavable maytansine and pyrrolobenzodiazepine-based antibody-drug conjugates
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-01-010
PRE
Kinneer, Krista; Meekin, John; Phipps, Sandrina; Bezabeh, Binyam; Fleming, Ryan; Kiefer, Christine; Rebelatto, Marlon; Dimasi, Nazzareno; Wick, Michael J.; Moriarty, Alyssa; Groves, Megan; Herbst, Ronald; Tiberghien, Arnaud; Masterson, Luke; Howard, Philip; Tice, David
ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
MOLECULAR CANCER THERAPEUTICS
IF5.5
2016-11-01103
OAAI
Flynn, Michael J.; Zammarchi, Francesca; Tyrer, Peter C.; Akarca, Ayse U.; Janghra, Narinder; Britten, Charles E.; Havenith, Carin E. G.; Levy, Jean-Noel; Tiberghien, Arnaud; Masterson, Luke A.; Barry, Conor; D'Hooge, Francois; Marafioti, Teresa; Parren, Paul W. H. I.; Williams, David G.; Howard, Philip W.; van Berkel, Patrick H.; Hartley, John A.
Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry
BIOCONJUGATE CHEMISTRY
IF3.9
2015-09-11150
PREAI
VanBrunt, Michael P.; Shanebeck, Kurt; Caldwell, Zachary; Johnson, Jeffrey; Thompson, Pamela; Martin, Thomas; Dong, Huifang; Li, Gary; Xu, Hengyu; D'Hooge, Francois; Masterson, Luke; Bariola, Pauline; Tiberghien, Arnaud; Ezeadi, Ebele; Williams, David G.; Hartley, John A.; Howard, Philip W.; Grabstein, Kenneth H.; Bowen, Michael K.; Marelli, Marcello
A Potent Anti-CD70 Antibody-Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology
BIOCONJUGATE CHEMISTRY
IF3.9
2013-06-28249
PREAI
Jeffrey, Scott C.; Burke, Patrick J.; Lyon, Robert P.; Meyer, David W.; Sussman, Django; Anderson, Martha; Hunter, Joshua H.; Leiske, Chris I.; Miyamoto, Jamie B.; Nicholas, Nicole D.; Okeley, Nicole M.; Sanderson, Russell J.; Stone, Ivan J.; Zeng, Weiping; Gregson, Stephen J.; Masterson, Luke; Tiberghien, Arnaud C.; Howard, Philip W.; Thurston, David E.; Law, Che-Leung; Senter, Peter D.
Structure-Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2010-04-08101
PREAI
Antonow, Dyeison; Kaliszczak, Maciej; Kang, Gyoung-Dong; Coffils, Marissa; Tiberghien, Arnaud C.; Cooper, Nectaroula; Barata, Teresa; Heidelberger, Sibylle; James, Colin H.; Zloh, Mire; Jenkins, Terence C.; Reszka, Anthony P.; Neidle, Stephen; Guichard, Sylvie M.; Jodrell, Duncan I.; Hartley, John A.; Howard, Philip W.; Thurston, David E.

研究方向

暂未获取到该数据
P
Philip W. Howard
H 指数:35论文数:220被引数:4,408
L
Luke A. Masterson
H 指数:21论文数:114被引数:1,776
J
John A. Hartley
H 指数:75论文数:506被引数:2.6万
P
Philip W. Howard
H 指数:12论文数:24被引数:736
D
David E. Thurston
H 指数:45论文数:341被引数:7,114
D
David G. Williams
H 指数:27论文数:135被引数:2,989
N
Nazzareno Dimasi
H 指数:33论文数:152被引数:3,699
J
Jeremy S. Parker
H 指数:25论文数:79被引数:2,261
F
François D’Hooge
H 指数:20论文数:68被引数:1,385
C
Conor S. Barry
H 指数:18论文数:44被引数:1,212