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Walter Becker

RWTH Aachen University

H指数:50

被引数:8,673

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DYRK1B Overexpression Promotes Senescence-Like Transcriptional and Secretory Programs in A549 Lung Cancer Cells

DYRK1B过表达促进A549肺癌细胞中衰老样转录和分泌程序

Biochemical and Biophysical Research Communications

IF2.2

2026-10-060

OAAI

The protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7

蛋白激酶DYRK1B是p53靶基因，并作为转录因子RFX7的负反馈调节因子发挥作用。

Cell Death & Disease

IF9.6

2026-03-260

OAAI

Elevated expression levels of the protein kinase DYRK1B induce mesenchymal features in A549 lung cancer cells

IF3.4

2024-10-310

OAAI

Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells

SCIENTIFIC REPORTS

IF3.9

2024-10-130

OAAI

Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-09-300

PRE

Functional characterization of two DYRK1B variants causative of AOMS3

ORPHANET JOURNAL OF RARE DISEASES

IF3.5

2024-06-120

OAAI

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B

SCIENTIFIC REPORTS

IF3.9

2022-02-145

OAAI

Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2022-01-0118

PRE

Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases

ACS CHEMICAL NEUROSCIENCE

IF3.9

2021-11-025

PREAI

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine

IF4.6

2020-12-1612

OAAI

Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-10-0117

PREAI

Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-09-0120

PREAI

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

IF4.6

2018-01-2424

OAAI

A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy

IF4.2

2017-12-1254

OAAI

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

SCIENTIFIC REPORTS

IF3.9

2017-07-2528

OAAI

The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2

SCIENTIFIC REPORTS

IF3.9

2016-06-1646

OAAI

DYRK protein kinases

CURRENT BIOLOGY

IF7.5

2015-06-0155

OAAI

10-lodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-03-2391

OAAI

Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK)

CELL COMMUNICATION AND SIGNALING

IF8.9

2015-01-2935

OAAI

The Down syndrome-related protein kinase DYRK1A phosphorylates p27Kip1 and Cyclin D1 and induces cell cycle exit and neuronal differentiation

IF3.4

2014-05-07141

OAAI