Philippe M. Loiseau - Publications, H-index & Citations

Philippe M. Loiseau

chimiothérapie antiparasitaire

48H指数

376论文数

9.1K被引数

收录论文 119

发表时间

Expanding the Role of Thiophilic Metals Derivatives in antiparasitic chemotherapy: Multi-Target Approaches Against Protozoan Parasites 扩展硫亲金属衍生物在抗寄生虫化疗中的作用：针对原虫寄生虫的多靶点方法

European Journal of Medicinal Chemistry Reports

IF4.1

2026-03-20

OAAI

Inês C.C. Costa; Philippe Loiseau; Maria L.S. Cristiano; Sandrine Cojean

Are hydrophilic deep eutectic solvents a potential vehicle for topical delivery of Amphotericin B against cutaneous leishmaniasis? An investigation of physicochemical properties, tolerability and antileishmanial efficacy 亲水性深共晶溶剂是否是局部递送Amphotericin B治疗皮肤利什曼病的潜在载体？对物理化学性质、耐受性及抗利什曼原虫活性的研究

International Journal of Pharmaceutics

IF5.2

2025-12-04

OAAI

Cảnh Hưng Nguyễn; Catherine Cailleau; Natalie Fournier; Luc Augis; Françoise Mercier-Nomé; Md Masudur Rahman; Maxime Annereau; Sébastien Pomel; Sandrine Cojean; Philippe M. Loiseau; Gillian Barratt; François-Xavier Legrand

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1; 2-a]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy 以药效团为指导对靶向酪蛋白激酶1的抗利什曼原虫治疗中具有潜力的咪唑并[1; 2-a]吡嗪衍生物进行先导化合物CTN1122的优化设计

RSC Med. Chem.

IF3.6

2025-08-14

PREAI

Lhana Tisseur; Cédric Logé; Sandrine Cojean; Khadidiatou Gassama; Lilian Karcher; Fabrice Pagniez; Christian Cavé; Guillaume Bernadat; Philippe M. Loiseau; Stéphane Bach; Jérôme Thiéfaine; Justine Bonnet; Carine Picot; Christophe Tomasoni; Olivier Leclercq; Blandine Baratte; Thomas Robert; Patrice Le Pape; Najma Rachidi; Marc-Antoine Bazin; Pascal Marchand

Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition 研究基于咪唑并 [1，2-a] 吡嗪的命中化合物CTN1122的C2调节: 合成，体外抗利什曼蛋白活性，细胞毒性和酪蛋白激酶1抑制

CHEMMEDCHEM

IF3.4

2025-01-06

PREAI

Tisseur, Lhana; Cojean, Sandrine; Gassama, Khadidiatou; Loge, Cedric; Pagniez, Fabrice; Cave, Christian; Bernadat, Guillaume; Loiseau, Philippe M.; Bach, Stephane; Thiefaine, Jerome; Picot, Carine; Tomasoni, Christophe; Leclercq, Olivier; Baratte, Blandine; Robert, Thomas; Le Pape, Patrice; Rachidi, Najma; Bazin, Marc-Antoine; Marchand, Pascal

Effect of Phlebotomus papatasi on the fitness, infectivity and antimony-resistance phenotype of antimony-resistant Leishmania major Mon-25 Papatatasi对抗锑利什曼原虫主要Mon-25的适应性，传染性和抗锑表型的影响

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

IF3.4

2024-08-01

OAAI

Mekarnia, Nalia; Benallal, Kamal-Eddine; Sadlova, Jovana; Vojtkova, Barbora; Mauras, Aurelie; Imbert, Nicolas; Longhitano, Maryline; Harrat, Zoubir; Volf, Petr; Loiseau, Philippe M.; Cojean, Sandrine

The Synthesis of 2′-Hydroxychalcones under Ball Mill Conditions and Their Biological Activities

MOLECULES

IF4.6

2024-04-17

OAAI

Abid, Imen; Moslah, Wassim; Cojean, Sandrine; Imbert, Nicolas; Loiseau, Philippe M.; Chamayou, Alain; Srairi-Abid, Najet; Calvet, Rachel; Baltas, Michel

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones

MOLECULES

IF4.6

2024-04-04

OAAI

Gendron, Thibault; Lanfranchi, Don Antoine; Wenzel, Nicole I.; Kessedjian, Hripsimee; Jannack, Beate; Maes, Louis; Cojean, Sandrine; Mueller, Thomas J. J.; Loiseau, Philippe M.; Davioud-Charvet, Elisabeth

Mechanochemical Studies on Coupling of Hydrazines and Hydrazine Amides with Phenolic and Furanyl Aldehydes-Hydrazones with Antileishmanial and Antibacterial Activities

MOLECULES

IF4.6

2023-07-07

OAAI

Kapusterynska, Anna; Bijani, Christian; Paliwoda, Damian; Vendier, Laure; Bourdon, Valerie; Imbert, Nicolas; Cojean, Sandrine; Loiseau, Philippe Marie; Recchia, Deborah; Scoffone, Viola Camilla; Degiacomi, Giulia; Akhir, Abdul; Saxena, Deepanshi; Chopra, Sidharth; Lubenets, Vira; Baltas, Michel

Synthesis of new 3-acetyl-1,3,4-oxadiazolines combined with pyrimidines as antileishmanial and antiviral agents 合成新的3-乙酰基-1，3，4-恶二唑啉与嘧啶结合作为抗利什曼和抗病毒剂

MOLECULAR DIVERSITY

IF3.8

2022-10-17

OAAI

Lachhab, Saida; El Mansouri, Az-eddine; Mehdi, Ahmad; Dennemont, Indira; Neyts, Johan; Jochmans, Dirk; Andrei, Graciela; Snoeck, Robert; Sanghvi, Yogesh S.; Ali, Mustapha Ait; Loiseau, Philippe M.; Lazrek, Hassan B.

Design of Anti-infectious Agents from Lawsone in a Three-Component Reaction with Aldehydes and Isocyanides

ACS OMEGA

IF4.3

2022-10-03

OAAI

Koumpoura, Christina L.; Nguyen, Michel; Bijani, Christian; Vendier, Laure; Salina, Elena G.; Buroni, Silvia; Degiacomi, Giulia; Cojean, Sandrine; Loiseau, Philippe M.; Benoit-Vical, Francoise; Garcia-Sosa, Alfonso T.; Robert, Anne; Baltas, Michel

Nanoassemblies from Amphiphilic Sb Complexes Target Infection Sites in Models of Visceral and Cutaneous Leishmaniases

PHARMACEUTICS

IF5.5

2022-08-21

OAAI

Lanza, Juliane S.; Vallejos, Virginia M. R.; Ramos, Guilherme S.; de Oliveira, Ana Carolina B.; Demicheli, Cynthia; Rivas, Luis; Pomel, Sebastien; Loiseau, Philippe M.; Frezard, Frederic

Pharmacokinetics, biodistribution, and activity of Amphotericin B-loaded nanocochleates on the Leishmania donovani murine visceral leishmaniasis model

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2022-08-01

PREAI

Castro, Antonio Lipa; Pomel, Sebastien; Cailleau, Catherine; Fournier, Natalie; Dennemont, Indira; Loiseau, Philippe M.; Barratt, Gillian

Formulation of Amphotericin B in PEGylated Liposomes for Improved Treatment of Cutaneous Leishmaniasis by Parenteral and Oral Routes

PHARMACEUTICS

IF5.5

2022-05-05

OAAI

Ramos, Guilherme S.; Vallejos, Virginia M. R.; Borges, Gabriel S. M.; Almeida, Raquel M.; Alves, Izabela M.; Aguiar, Marta M. G.; Fernandes, Christian; Guimaraes, Pedro P. G.; Fujiwara, Ricardo T.; Loiseau, Philippe M.; Ferreira, Lucas A. M.; Frezard, Frederic

Targeting chalcone binding sites in living Leishmania using a reversible fluorogenic benzochalcone probe

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2022-05-01

OAAI

Batista, Ariane S.; Oliveira, Suellen D. S.; Pomel, Sebastien; Commere, Pierre-Henri; Mazan, Valerie; Lee, Moses; Loiseau, Philippe M.; Rossi-Bergmann, Bartira; Prina, Eric; Duval, Romain

The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates 2-取代的喹啉作为抗利什曼药物候选物的潜力

MOLECULES

IF4.6

2022-04-02

OAAI

Loiseau, Philippe M.; Balaraman, Kaluvu; Barratt, Gillian; Pomel, Sebastien; Durand, Remy; Frezard, Frederic; Figadere, Bruno

Minor Impact of A258D Mutation on Biochemical and Enzymatic Properties of Leishmania infantum GDP-Mannose Pyrophosphorylase

MICROORGANISMS

IF4.2

2022-01-21

OAAI

Mao, Wei; Lazar, Noureddine; van Tilbeurgh, Herman; Loiseau, Philippe M.; Pomel, Sebastien

Intranasal vaccine from whole Leishmania donovani antigens provides protection and induces specific immune response against visceral leishmaniasis

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2021-08-17

OAAI

Helou, Doumet Georges; Mauras, Aurelie; Fasquelle, Francois; Lanza, Juliane Sousa; Loiseau, Philippe M.; Betbeder, Didier; Cojean, Sandrine

An adamantamine derivative as a drug candidate for the treatment of visceral leishmaniasis

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

IF3.6

2021-07-02

OAAI

Pomel, Sebastien; Cojean, Sandrine; Pons, Valerie; Cintrat, Jean-Christophe; Nguyen, Laetitia; Vacus, Joel; Pruvost, Alain; Barbier, Julien; Gillet, Daniel; Loiseau, Philippe M.

Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities

MOLECULES

IF4.6

2021-03-11

OAAI

Levaique, Helene; Pamlard, Olivier; Apel, Cecile; Bignon, Jerome; Arriola, Margaux; Kuhner, Robin; Awang, Khalijah; Loiseau, Philippe M.; Litaudon, Marc; Pomel, Sebastien

Drugs used for the treatment of cerebral and disseminated infections caused by free-living amoebae

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2021-03-01

OAAI

Taravaud, Alexandre; Fechtali-Moute, Zineb; Loiseau, Philippe M.; Pomel, Sebastien

研究方向