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Alice Ke

certara uk limited, simcyp division, sheffield, uk

H指数:18

被引数:1,193

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Sensitivity of Tepotinib to Inhibitors or Inducers of CYP3A4 and P-Gp: Drug Interaction Studies and Physiologically-Based Pharmacokinetic Analysis

Tepotinib对CYP3A4或P-Gp抑制剂或诱导剂的敏感性：药物相互作用研究及生理药代动力学分析

cts clinical and translational science

IF0

2025-07-180

OA

Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2024-03-291

OAAI

Physiologically-based pharmacokinetic modeling of the drug-drug interaction between ivacaftor and lefamulin in cystic fibrosis patients

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2024-02-010

OAAI

Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2022-04-2824

OA

Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2022-03-028

OA

PBPK modeling to predict drug-drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2021-05-0126

OAAI

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2020-07-1631

OAAI

A physiologically based pharmacokinetic-pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug -drug interactions of paclitaxel in cancer patients

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2020-07-0114

PREAI

Quantitative Prediction of the Role of Placental Efflux to Optimize Dosing Regimens of Dexamethasone and Betamethasone to Prevent Respiratory Distress Syndrome

IF4.2

2020-04-200

PRE

Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2020-01-1110

OAAI

Evaluation of Maternal Drug Exposure Following the Administration of Antenatal Corticosteroids During Late Pregnancy Using Physiologically-Based Pharmacokinetic Modeling

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2019-05-0633

PREAI

Model-Informed Drug Development for Ixazomib, an Oral Proteasome Inhibitor

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2018-03-239

OAAI

Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2018-01-3156

OAAI

Physiologically based pharmacokinetic model development for trazodone: application to paediatric dose projection

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2017-10-010

PREAI

Preclinical and clinical studies and modeling and simulation to identify phase II dose for cerdulatinib: a dual SYK/JAK inhibitor for the treatment of B-cell malignancies

CANCER RESEARCH

IF16.6

2016-07-150

PRE

Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2015-08-0114

OAAI

Itraconazole and Clarithromycin as Ketoconazole Alternatives for Clinical CYP3A Inhibition Studies

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2014-05-0161

PREAI

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

PBPK模型的扩展，以预测孕妇通过多种CYP酶清除的药物的处置，包括CYP2B6，CYP2C9和CYP2C19

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2014-02-21103

OAAI

Pharmacometrics in Pregnancy: An Unmet Need

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY

IF0

2014-01-0682

OA

Modeling Cyclosporine A Inhibition of the Distribution of a P-Glycoprotein PET Ligand, 11C-Verapamil, into the Maternal Brain and Fetal Liver of the Pregnant Nonhuman Primate: Impact of Tissue Blood Flow and Site of Inhibition

JOURNAL OF NUCLEAR MEDICINE

IF9.1

2013-01-2832

OA