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Yongyuth Yuthavong

National Science and Technology Development Agency

H指数:44

被引数:7,194

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Repurpose Antimalarials to Target Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase

重新利用抗疟药靶向弓形虫二氢叶酸还原酶胸苷酸合成酶

European Journal of Medicinal Chemistry

IF5.9

2026-04-190

OAAI

Lipophilic Pyrimethamine analogs with anti-toxoplasmosis activity

脂溶性乙胺嘧啶类似物，具有抗弓形虫活性

infection, genetics and evolution

IF0

2026-03-280

OAAI

Novel flexible biphenyl PfDHFR inhibitors with improved antimalarial activity

RSC MEDICINAL CHEMISTRY

IF3.6

2024-01-010

PRE

Discovery of rigid biphenyl Plasmodium falciparum DHFR inhibitors using a fragment linking strategy

RSC MEDICINAL CHEMISTRY

IF3.6

2023-01-014

PRE

Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine-2,4-diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase

IF3.4

2022-11-022

OA

Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase

ACS CHEMICAL BIOLOGY

IF3.8

2022-06-177

PRE

Assay Development and Identification of the First Plasmodium falciparum 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Inhibitors

IF4.6

2022-05-300

OAAI

New Insights into Antimalarial Chemopreventive Activity of Antifolates

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2022-02-1510

OA

Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug

INTERNATIONAL JOURNAL FOR PARASITOLOGY

IF3.2

2021-07-019

OAAI

Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

IF5.4

2021-02-029

OAAI

Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-06-0117

PREAI

The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance

IF4.2

2020-01-1922

OAAI

6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2019-12-0110

PREAI

Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

IF3

2019-05-015

PREAI

Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2018-11-0723

OAAI

Role of Plasmodium vivax Dihydropteroate Synthase Polymorphisms in Sulfa Drug Resistance

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2016-08-0126

OAAI

Identifying antimalarial compounds targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS) by chemogenomic profiling

INTERNATIONAL JOURNAL FOR PARASITOLOGY

IF3.2

2016-07-0124

PREAI

Estimating mRNA lengths from Plasmodium falciparum genes by Virtual Northern RNA-seq analysis

INTERNATIONAL JOURNAL FOR PARASITOLOGY

IF3.2

2016-01-016

PREAI

Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study

IF3.7

2015-10-2133

OAAI

Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-03-1860

PREAI