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A

Aurora Valeri

molecular horizon srl
H指数:11
被引数:676

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A Polypharmacology-Driven Approach to Alzheimer’s Disease and Tauopathies: Rational Design; Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3β/FYN-α/DYRK1A) Inhibitors

基于多靶点药物策略的阿尔茨海默病和tau蛋白病研究：氨基酸-吡唑类多靶点激酶（GSK-3β/FYN-α/DYRK1A）抑制剂的理性设计、合成与表征

Journal of Medicinal Chemistry
IF6.8
2026-04-290
OA
Stefania Demuro; Debora Russo; Ilaria Penna; Siranuysh Grabska; Hovakim Grabski; Andrea Dalle Vedove; Aurora Valeri; Conall Sauvey; Giuliana Ottonello; Maria Summa; Sine Mandrup Bertozzi; Jose Ortega; Rosalia Bertorelli; Paola Storici; Stefania Girotto; Gabriele Cruciani; Rita M. C. Di Martino; Ruben Abagyan; Andrea Cavalli
Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies

基于理性的D3R/GSK-3β双靶点导向配体的优化及其作为双相情感障碍潜在治疗药物的研究：设计、合成、X射线晶体学、分子动力学模拟、体外ADME及体内药代动力学研究

European Journal of Medicinal Chemistry
IF5.9
2025-06-250
PRE
R.M.C. Di Martino; D. Russo; I. Penna; S. Demuro; A. Dalle Vedove; R. Spagnuolo; G. Ottonello; S.M. Bertozzi; M. Summa; J. Desantis; A. Valeri; L. Pruccoli; S.K. Tripathi; A. Tarozzi; P. Storici; S. Girotto; R. Bertorelli; A. Armirotti; G. Cruciani; T. Bandiera; A. Cavalli; G. Bottegoni

研究方向

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G
Gabriele Cruciani
H 指数:61论文数:353被引数:1.3万
L
Laura Goracci
H 指数:38论文数:163被引数:3,837
R
Roberto Maria Pellegrino
H 指数:24论文数:130被引数:2,374
M
Massimo Valoti
H 指数:30论文数:167被引数:3,337
R
Rosalia Bertorelli
H 指数:46论文数:143被引数:6,625
M
Maria Summa
H 指数:31论文数:96被引数:2,735
S
Stefania Girotto
H 指数:22论文数:76被引数:1,837
D
Debora Russo
H 指数:23论文数:74被引数:1,769
S
Sara Tortorella
H 指数:16论文数:33被引数:839
S
Susan Lepri
H 指数:11论文数:27被引数:534