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H

Hua Nie

Medical College
H指数:8
被引数:158

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Design, Synthesis and Biological Evaluation of 6H-Benzimidazo[1′,2′:1,2]pyrido[3,4-b]indole Derivatives as TDP1 Inhibitors: Potent Synergistic Agents with Topotecan against Cervical Cancer

6H-苯并咪唑[1′,2′:1,2]吡啶[3,4-b]吲哚衍生物的设计、合成及生物评价：作为TDP1抑制剂的强效协同剂，与拓扑替康联合抗宫颈癌

Journal of Medicinal Chemistry
IF6.8
2026-04-010
PRE
Zeng, Huang; Qiu, Bo; Yang, Jiunlong; Xie, Yuman; Huang, Hui; Zhang, Shengyuan; Nie, Hua; Wang, Nan; Huang, Zeyong; Wu, Lingfeng; Liu, Jiayao; Zheng, Xuerou; Zhuang, Yuanbei; Yang, Hao
Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecular dynamic simulation

Dendropanax proteus根及其主要生物植物化学物质通过抑制TLR4/CLEC1B/PI3K/Akt/NF-κB通路缓解类风湿关节炎：蛋白质组学、代谢组学、胶原诱导性关节炎大鼠、MH7A细胞、分子对接和分子动力学模拟

Journal of Ethnopharmacology
IF5.4
2025-11-140
PRE
Li Yang; Yating Yang; Qihui Wang; Jian Liang; Shengyuan Zhang; Hua Nie; Huang Zeng; Junwei He
Discovery of a potent TDP1 inhibitor through machine learning-driven predictive modeling combined with structure-based virtual screening and experimental validation

通过机器学习驱动的预测建模、基于结构的虚拟筛选与实验验证相结合发现一种高效的TDP1抑制剂

RSC Advances
IF4.6
0
PRE
Huang Zeng Corresponding Author; Manyi Zhang; Bo Qiu; Shengyuan Zhang; Jiayao Liu; Xiaodong Luo; Lingfeng Wu; Huasong Xie; Ming Zhai; Jiunlong Yang; Hao Yang; Hua Nie Corresponding Author; Nan Wang Corresponding Author

研究方向

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S
Shengyuan Zhang
H 指数:16论文数:68被引数:1,017
Q
Qi-Xuan Yang
H 指数:2论文数:6被引数:24
X
Xiaodong Luo
H 指数:7论文数:22被引数:104
刘
刘晓敏
H 指数:54论文数:319被引数:9,706
Y
Yi Cheng
H 指数:18论文数:42被引数:870
杨
杨浩
H 指数:12论文数:38被引数:549
H
Huang Zeng
H 指数:3论文数:6被引数:30
M
Ming Zhai
H 指数:12论文数:49被引数:440
P
Pin-Jing Zheng
H 指数:3论文数:8被引数:92
J
Jiunlong Yang
H 指数:1论文数:5被引数:4