Gaozhi Chen

Wenzhou Medical University

H指数:20

被引数:1,761

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n-Butylphthalide alleviates obesity-induced cardiomyopathy by binding directly to Keap1

川芎嗪通过直接与Keap1结合缓解肥胖诱导的心肌病

International Immunopharmacology

IF4.7

2025-11-200

PRE

10-hydroxydec-2-enoic acid alleviates post-myocardial infarction inflammation and oxidative stress by modulating the TLR4 signaling axis

10-羟基癸烯-2-酸通过调节TLR4信号轴来减轻心肌梗死后炎症和氧化应激。

Phytomedicine

IF8.3

2025-10-260

PRE

10-Hydroxy-2-decenoic acid ameliorates LPS-induced acute lung injury through targeting MD2-mediated inflammatory signaling pathways

10-Hydroxy-2-decenoic acid通过靶向MD2介导的炎症信号通路改善LPS诱导的急性肺损伤

Toxicology and Applied Pharmacology

IF3.4

2025-10-040

PRE

Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1

DL-3-正丁基苯酞通过抑制Nrf2/Keap1的结合来减轻急性心肌梗死

Toxicology and Applied Pharmacology

IF3.4

2025-06-060

PRE

Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling

通过抑制NF-κB/MAPK信号通路，槲皮素对肥胖性心肌病的缓解作用

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2025-04-010

PRE

FGF-based drug discovery: advances and challenges

FGF为基础的药物发现：进展与挑战

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2025-01-284

PRE

New drug combination regimen based on pharmacokinetic characteristics-Erdafitinib combined with sertraline or duloxetine

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2024-10-010

OAAI

C-terminal fragment of fibroblast growth factor 23 improves heart function in murine models of high intact fibroblast growth factor 23

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

IF3.4

2024-04-013

PRE

Determine the enzymatic kinetic characteristics of CYP3A4 variants utilizing artemether-lumefantrine

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2023-11-012

PRE

Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

麦角内酯共价结合NLRP3并抑制NLRP3炎性小体介导的焦亡

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2023-07-0111

PRE

Structural basis for FGF hormone signalling

Nature

IF48.5

2023-06-070

OAAI

Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-05-0210

PRE

Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-03-0110

PRE

A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2021-10-016

PRE

Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-KB signaling pathways

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2021-09-0122

OAAI

Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy

ACTA PHARMACOLOGICA SINICA

IF8.4

2020-04-2715

OAAI

C-FGF23 peptide alleviates hypoferremia during acute inflammation

HAEMATOLOGICA

IF7.9

2020-03-1927

OAAI

Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-01-0135

PREAI

Discovery of new MD2-targeted anti-inflammatory compounds for the treatment of sepsis and acute lung injury

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-10-0127

PREAI

Myeloid differentiation protein 2-dependent mechanisms in retinal ischemia-reperfusion injury

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2017-02-0116

PREAI

Gaozhi Chen

个人简介

教育背景

工作经历

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