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Z

Zhiguo Liu

Wenzhou Medical University
H指数:33
被引数:3,611

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Discovery and Structural Optimization of Novel 2-Aminopyrimidine Derivatives as Potent and Selective IKKβ Inhibitors for the Treatment of Colorectal Cancer

新型2-氨基嘧啶衍生物的发现与结构优化：作为强效且选择性IKKβ抑制剂的结直肠癌治疗药物

Journal of Medicinal Chemistry
IF6.8
2025-12-020
PRE
Kun Wang; Yina Hu; Peng Liu; Changgui Shi; Jinke Yuan; Youshuo Zang; Yeying He; Bin Li; Jiahao Zheng; Jiaying Tong; Chaoyue Chen; Lehao Huang; Fangjun Zhang; Xiaohui Zheng; Zhiguo Liu
Exploring the antitumor effect of curcumin-piperlongumine hybrid molecule (CP) on EGFR-TKI-resistant non-small cell lung cancer using network pharmacological analysis and experimental verification

利用网络药理学分析和实验验证探索姜黄素-长胡椒碱杂合分子(CP)对EGFR-TKI耐药的非小细胞肺癌的抗肿瘤作用

ACTA BIOCHIMICA ET BIOPHYSICA SINICA
IF3.4
2025-11-010
PRE
Wang, Shiyu; Lai, Yinshuang; Huang, Huijing; Yuan, Jing; Li, Shanxin; Hui, Min; Wang, Peipei; Chen, Bingbing; Liu, Zhiguo; Qian, Jianchang; Zhang, Qianwen
Discovery of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent and Selective FGFR Inhibitors against Gatekeeper Mutants for the Treatment of NSCLC

新型2,4,5-三取代嘧啶衍生物作为针对门控突变体的强效且选择性FGFR抑制剂的发现，用于NSCLC的治疗

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-03-030
PRE
Zhang, Jianxia; Wang, Yi; Wang, Mengying; Wang, Peipei; Yan, Hao; Wang, Dalong; Zheng, Jiahao; Li, Bin; Chen, Chaoyue; Cao, Di; Zheng, Xiaohui; Li, Xiaokun; Wang, Kun; Liu, Zhiguo

研究方向

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梁
梁广
H 指数:64论文数:479被引数:1.4万
Y
Yunjie Zhao
H 指数:39论文数:210被引数:5,466
X
Xiaokun Li
H 指数:89论文数:744被引数:2.7万
梁
梁广
H 指数:44论文数:168被引数:5,825
Y
Yali Zhang
H 指数:29论文数:66被引数:2,312
陈凌峰 封面图
陈凌峰
H 指数:34论文数:183被引数:4,233
B
Bo Fang
H 指数:11论文数:24被引数:337
X
Xiaohui Zheng
H 指数:22论文数:87被引数:1,847
G
Gaozhi Chen
H 指数:20论文数:49被引数:1,761
Y
Yuepiao Cai
H 指数:27论文数:88被引数:2,220