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Aki T. Heikkinen

certara predictive technologies

H指数:19

被引数:1,072

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Investigating Sulfotransferase Mediated Drug Interactions of Ethinylestradiol using a Physiologically Based Pharmacokinetic Model

使用生理药代动力学模型研究乙炔基雌二醇的磺基转移酶介导的药物相互作用

The AAPS Journal

IF0

2025-11-040

PRE

Physiologically based pharmacokinetic modeling of aldehyde oxidase drug-drug interactions mediated by erlotinib

基于生理的醛氧化酶介导的厄洛替尼药物-药物相互作用药代动力学建模

Drug Metabolism and Disposition

IF4

2025-06-230

PRE

Development of a PBPK Model for Lamotrigine which Incorporates Metabolism by UGT2B10: Impact of UGT2B10 Poor Metabolizer Phenotype and Pregnancy

IF3.7

2025-02-040

PRE

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2024-10-301

OAAI

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5′-Diphospho-glucuronosyltransferase Substrates

IF5.5

2021-08-2415

OAAI

In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2020-01-015

OAAI

Pharmacokinetics of intranasal fentanyl in parturient

BRITISH JOURNAL OF ANAESTHESIA

IF9.2

2015-10-015

OAAI

Quantitative ADME Proteomics - CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

PHARMACEUTICAL RESEARCH

IF4.3

2014-07-1849

PREAI

Applications of a 7-day Caco-2 cell model in drug discovery and development

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2014-06-0142

PREAI

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates - An evaluation and case study using GastroPlus™

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2012-09-0175

PREAI

Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

PHARMACEUTICAL RESEARCH

IF4.3

2012-02-2233

PREAI

Determination of permeation resistance distribution in in vitro cell monolayer permeation experiments

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2010-05-0110

PREAI

Analysis of Unstirred Water Layer in In Vitro Permeability Experiments

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2009-12-01116

PREAI

Transplacental Transfer of Nitrosodimethylamine in Perfused Human Placenta

IF2.5

2009-03-0132

PREAI

Kinetics of Cellular Retention during Caco-2 Permeation Experiments: Role of Lysosomal Sequestration and Impact on Permeability Estimates

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2009-03-0129

PREAI

In vitro-in vivo correlation in p-glycoprotein mediated transport in intestinal absorption

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2009-02-0144

PREAI

The asymmetry of the unstirred water layer in permeability experiments

PHARMACEUTICAL RESEARCH

IF4.3

2008-04-1643

PREAI

Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2008-01-045

PREAI