未登录 Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ Kiourtis, Christos; Terradas-Terradas, Maria; Gee, Lucy M.; May, Stephanie; Georgakopoulou, Anastasia; Collins, Amy L.; O'Sullivan, Eoin D.; Baird, David P.; Hassan, Mohsin; Shaw, Robin; Tan, Ee Hong; Mueller, Miryam; Engelmann, Cornelius; Andreola, Fausto; Hsieh, Ya-Ching; Reed, Lee H.; Borthwick, Lee A.; Nixon, Colin; Clark, William; Hanson, Peter S.; Sumpton, David; Mackay, Gillian; Suzuki, Toshiyasu; Najumudeen, Arafath K.; Inman, Gareth J.; Campbell, Andrew; Barry, Simon T.; Quaglia, Alberto; Morris, Christopher M.; Lebeau, Fiona E. N.; Sansom, Owen J.; Kirschner, Kristina; Jalan, Rajiv; Oakley, Fiona; Bird, Thomas G. 分享 收藏
Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression 环肌酸抑制肌酸代谢并损害前列腺癌进展 Patel, Rachana; Ford, Catriona A.; Rodgers, Lisa; Rushworth, Linda K.; Fleming, Janis; Mui, Ernest; Zhang, Tong; Watson, David; Lynch, Victoria; Mackay, Gillian; Sumpton, David; Sansom, Owen J.; Vande Voorde, Johan; Leung, Hing Y. 分享 收藏
THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer 脂质代谢的THEM6-mediated重编程支持前列腺癌的治疗抵抗 Blomme, Arnaud; Peter, Coralie; Mui, Ernest; Blanco, Giovanny Rodriguez; An, Ning; Mason, Louise M.; Jamieson, Lauren E.; McGregor, Grace H.; Lilla, Sergio; Ntala, Chara; Patel, Rachana; Thiry, Marc; Kung, Sonia H. Y.; Leclercq, Marine; Ford, Catriona A.; Rushworth, Linda K.; McGarry, David J.; Mason, Susan; Repiscak, Peter; Nixon, Colin; Salji, Mark J.; Markert, Elke; MacKay, Gillian M.; Kamphorst, Jurre J.; Graham, Duncan; Faulds, Karen; Fazli, Ladan; Gleave, Martin E.; Avezov, Edward; Edwards, Joanne; Yin, Huabing; Sumpton, David; Blyth, Karen; Close, Pierre; Murphy, Daniel J.; Zanivan, Sara; Leung, Hing Y. 分享 收藏
SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer SLFN5调节去势抵抗性前列腺癌的LAT1-Mediated mTOR激活 Martinez, Rafael S.; Salji, Mark J.; Rushworth, Linda; Ntala, Chara; Blanco, Giovanny Rodriguez; Hedley, Ann; Clark, William; Peixoto, Paul; Hervouet, Eric; Renaude, Elodie; Kung, Sonia H. Y.; Galbraith, Laura C. A.; Nixon, Colin; Lilla, Sergio; Mackay, Gillian M.; Fazli, Ladan; Gaughan, Luke; Sumpton, David; Gleave, Martin E.; Zanivan, Sara; Blomme, Arnaud; Leung, Hing Y. 分享 收藏
PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer Galbraith, Laura C. A.; Mui, Ernest; Nixon, Colin; Hedley, Ann; Strachan, David; MacKay, Gillian; Sumpton, David; Sansom, Owen J.; Leung, Hing Y.; Ahmad, Imran 分享 收藏
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase Savino, Angela Maria; Fernandes, Sara Isabel; Olivares, Orianne; Zemlyansky, Anna; Cousins, Antony; Markert, Elke K.; Barel, Shani; Geron, Ifat; Frishman, Liron; Birger, Yehudit; Eckert, Cornelia; Tumanov, Sergey; MacKay, Gillian; Kamphorst, Jurre J.; Herzyk, Pawel; Fernandez-Garcia, Jonatan; Abramovich, Ifat; Mor, Inbal; Bardini, Michela; Barin, Ersilia; Janaki-Raman, Sudha; Cross, Justin R.; Kharas, Michael G.; Gottlieb, Eyal; Izraeli, Shai; Halsey, Christina 分享 收藏
Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition Roca-Portoles, Alba; Rodriguez-Blanco, Giovanny; Sumpton, David; Cloix, Catherine; Mullin, Margaret; Mackay, Gillian M.; O'Neill, Katelyn; Lemgruber, Leandro; Luo, Xu; Tait, Stephen W. G. 分享 收藏
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2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer 2，4-二烯酰辅酶a还原酶调节治疗抵抗性前列腺癌的脂质稳态 Blomme, Arnaud; Ford, Catriona A.; Mui, Ernest; Patel, Rachana; Ntala, Chara; Jamieson, Lauren E.; Planque, Melanie; McGregor, Grace H.; Peixoto, Paul; Hervouet, Eric; Nixon, Colin; Salji, Mark; Gaughan, Luke; Markert, Elke; Repiscak, Peter; Sumpton, David; Blanco, Giovanny Rodriguez; Lilla, Sergio; Kamphorst, Jurre J.; Graham, Duncan; Faulds, Karen; MacKay, Gillian M.; Fendt, Sarah-Maria; Zanivan, Sara; Leung, Hing Y. 分享 收藏
Formate induces a metabolic switch in nucleotide and energy metabolism 甲酸诱导核苷酸和能量代谢中的代谢转换 Oizel, Kristell; Tait-Mulder, Jacqueline; Fernandez-de-Cossio-Diaz, Jorge; Pietzke, Matthias; Brunto, Holly; Lilla, Sergio; Dhayade, Sandeep; Athineos, Dimitri; Blanco, Giovanny Rodriguez; Sumpton, David; Mackay, Gillian M.; Blyth, Karen; Zanivan, Sara R.; Meiser, Johannes; Vazquez, Alexei 分享 收藏
Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer Patel, Rachana; Brzezinska, Elspeth A.; Repiscak, Peter; Ahmad, Imran; Mui, Ernest; Gao, Meiling; Blomme, Arnaud; Harle, Victoria; Tan, Ee Hong; Malviya, Gaurav; Mrowinska, Agata; Loveridge, Carolyn J.; Rushworth, Linda K.; Edwards, Joanne; Ntala, Chara; Nixon, Colin; Hedley, Ann; Mackay, Gillian; Tardito, Saverio; Sansom, Owen J.; Leung, Hing Y. 分享 收藏
Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab Bellier, Justine; Nokin, Marie-Julie; Caprasse, Maurine; Tiamiou, Assia; Blomme, Arnaud; Scheijen, Jean L.; Koopmansch, Benjamin; MacKay, Gillian M.; Chiavarina, Barbara; Costanza, Brunella; Rademaker, Gilles; Durieux, Florence; Agirman, Ferman; Maloujahmoum, Naima; Cusumano, Pino G.; Lovinfosse, Pierre; Leung, Hing Y.; Lambert, Frederic; Bours, Vincent; Schalkwijk, Casper G.; Hustinx, Roland; Peulen, Olivier; Castronovo, Vincent; Bellahcene, Akeila 分享 收藏
Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response McGregor, Grace H.; Campbell, Andrew D.; Fey, Sigrid K.; Tumanov, Sergey; Sumpton, David; Blanco, Giovanny Rodriguez; Mackay, Gillian; Nixon, Colin; Vazquez, Alexei; Sansom, Owen J.; Kamphorst, Jurre J. 分享 收藏
N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis Juin, Amelie; Spence, Heather J.; Martin, Kirsty J.; McGhee, Ewan; Neilson, Matthew; Cutiongco, Marie F. A.; Gadegaard, Nikolaj; Mackay, Gillian; Fort, Loic; Lilla, Sergio; Kalna, Gabriela; Thomason, Peter; Koh, Yvette W. H.; Norman, Jim C.; Insall, Robert H.; Machesky, Laura M. 分享 收藏
Improving the metabolic fidelity of cancer models with a physiological cell culture medium Voorde, Johan Vande; Ackermann, Tobias; Pfetzer, Nadja; Sumpton, David; Mackay, Gillian; Kalna, Gabriela; Nixon, Colin; Blyth, Karen; Gottlieb, Eyal; Tardito, Saverio 分享 收藏
Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth AT13148抑制Rho激酶阻断胰腺导管腺癌侵袭和肿瘤生长 Rath, Nicola; Munro, June; Cutiongco, Marie Francene; Jagieffo, Alicja; Gadegaard, Nikolaj; McGarry, Lynn; Unbekandt, Mathieu; Michalopoulou, Evdokia; Kamphorst, Jurre J.; Sumpton, David; Mackay, Gillian; Vennin, Claire; Pajic, Marina; Timpson, Paul; Olson, Michael F. 分享 收藏
Increased formate overflow is a hallmark of oxidative cancer Meiser, Johannes; Schuster, Anne; Pietzke, Matthias; Vande Voorde, Johan; Athineos, Dimitris; Oizel, Kristell; Burgos-Barragan, Guillermo; Wit, Niek; Dhayade, Sandeep; Morton, Jennifer P.; Dornier, Emmanuel; Sumpton, David; Mackay, Gillian M.; Blyth, Karen; Patel, Ketan J.; Niclou, Simone P.; Vazquez, Alexei 分享 收藏
Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1 Patel, Rachana; Fleming, Janis; Mui, Ernest; Loveridge, Carolyn; Repiscak, Peter; Blomme, Arnaud; Harle, Victoria; Salji, Mark; Ahmad, Imran; Teo, Katy; Hamdy, Freddie C.; Hedley, Ann; van den Broek, Niels; Mackay, Gillian; Edwards, Joanne; Sansom, Owen J.; Leung, Hing Y. 分享 收藏
Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells 谷氨酰胺分解驱动膜运输以促进乳腺癌细胞的侵袭 Dornier, Emmanuel; Rabas, Nicolas; Mitchell, Louise; Novo, David; Dhayade, Sandeep; Marco, Sergi; Mackay, Gillian; Sumpton, David; Pallares, Maria; Nixon, Colin; Blyth, Karen; Macpherson, Iain R.; Rainero, Elena; Norman, Jim C. 分享 收藏
LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells Susanto, Olivia; Koh, Yvette W. H.; Morrice, Nick; Tumanov, Sergey; Thomason, Peter A.; Nielson, Matthew; Tweedy, Luke; Muinonen-Martin, Andrew J.; Kamphorst, Jurre J.; Mackay, Gillian M.; Insall, Robert H. 分享 收藏
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