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M

Michael J. Eck

Harvard Medical School
H指数:89
被引数:4.7万

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荣誉奖项

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RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor

MEK抑制剂的RAF异构体选择性及共价ARAF-MEK抑制剂的理性设计

Science Advances
IF12.5
2026-10-230
OAAI
Sayan Chakraborty; Jie Jiang; Javier Vinals Camallonga; Dimitris Gazgalis; Thomas W. Gero; Maurício T. Tavares; Georgia Dittemore; Emre Tkacik; Tyler S. Beyett; Dong Man Jang; Byung Hak Ha; Felix H. Gottlieb; Talya Levitz; Rebecca J. Metivier; Anna M. Schmoker; David A. Scott; Hyesung Jeon; Pasi A. Jänne; Michael J. Eck
Deciphering the Structure−Activity Relationships Underpinning the Linkerology of Bivalent EGFR Inhibitors

解析支撑双价EGFR抑制剂连接体学的构效关系

Journal of Medicinal Chemistry
IF6.8
2026-01-010
PRE
Kishan B. Patel; Ishola Abeeb Akinwumi; Tess M. Weber; Monica R. MacDonald; Stephen J. Collins; Surbhi P. Chitnis; Colton L. Zack; Blessing C. Ogboo; Nader N. Nasief; Emily A. Ouellette; Omobolanle A. Abidakun; Michael J. Eck; Asher L. Brandt; Florian Wittlinger; Stefan Laufer; Hung Tan Nguyen; David E. Heppner
Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

作者更正：FGFR 突变和共突变的多样化景观表明儿童低级别胶质瘤中存在潜在的治疗策略

Nature Communications
IF15.7
2025-10-090
OA
April A. Apfelbaum; Eric Morin; Dominik Sturm; Georges Ayoub; Jeromy DiGiacomo; Sher Bahadur; Bhavyaa Chandarana; Phoebe C. Power; Margaret M. Cusick; Dana Novikov; Prem Prabhakar; Robert E. Jones; Jayne Vogelzang; Connor C. Bossi; Seth Malinowski; Lewis M. Woodward; Tania A. Jones; John Jeang; Sarah W. Lamson; Jared Collins; Kelly Y. Cai; Jacquelyn S. Jones; Sehee Oh; Hyesung Jeon; Jinhua Wang; Amy Cameron; Patrick Rechter; Angela De Leon; Karthikeyan Murugesan; Meagan Montesion; Lee A. Albacker; Shakti H. Ramkissoon; Cornelis M. van Tilburg; Emily C. Hardin; Philipp Sievers; Felix Sahm; Kee Kiat Yeo; Tom Rosenberg; Susan N. Chi; Karen D. Wright; Steven Hébert; Sydney Peck; Alberto Picca; Valérie Larouche; Samuele Renzi; Sara J. Buhrlage; Tejus A. Bale; Amy A. Smith; Mehdi Touat; Nada Jabado; Eric S. Fischer; Michael J. Eck; Lissa Baird; Olaf Witt; Claudia L. Kleinman; Quang-De Nguyen; Denise Sheer; Sanda Alexandrescu; David T. W. Jones; Keith L. Ligon; Pratiti Bandopadhayay
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

FGFR变异和共突变多样性的景观表明儿科低级别胶质瘤存在潜在的治疗策略

Nature Communications
IF15.7
2025-07-310
OAAI
April A. Apfelbaum; Eric Morin; Dominik Sturm; Georges Ayoub; Jeromy DiGiacomo; Sher Bahadur; Bhavyaa Chandarana; Phoebe C. Power; Margaret M. Cusick; Dana Novikov; Prem Prabhakar; Robert E. Jones; Jayne Vogelzang; Connor C. Bossi; Seth Malinowski; Lewis M. Woodward; Tania A. Jones; John Jeang; Sarah W. Lamson; Jared Collins; Kelly Y. Cai; Jacquelyn S. Jones; Sehee Oh; Hyesung Jeon; Jinhua Wang; Amy Cameron; Patrick Rechter; Angela De Leon; Karthikeyan Murugesan; Meagan Montesion; Lee A. Albacker; Shakti H. Ramkissoon; Cornelis M. van Tilburg; Emily C. Hardin; Philipp Sievers; Felix Sahm; Kee Kiat Yeo; Tom Rosenberg; Susan N. Chi; Karen D. Wright; Steven Hébert; Sydney Peck; Alberto Picca; Valérie Larouche; Samuele Renzi; Sara J. Buhrlage; Tejus A. Bale; Amy A. Smith; Mehdi Touat; Nada Jabado; Eric S. Fischer; Michael J. Eck; Lissa Baird; Olaf Witt; Claudia L. Kleinman; Quang-De Nguyen; Denise Sheer; Sanda Alexandrescu; David T. W. Jones; Keith L. Ligon; Pratiti Bandopadhayay
Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent Type V Kinase Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-12-030
PRE
Wittlinger, Florian; Chitnis, Surbhi P.; Pham, Calvin D.; Damghani, Tahereh; Patel, Kishan B.; Moellers, Mareike; Schaeffner, Ilse K.; Abidakun, Omobolanle A.; Deng, Matthew Q.; Ogboo, Blessing C.; Rasch, Alexander; Beyett, Tyler S.; Buckley, Brian; Feru, Frederic; Shaurova, Tatiana; Knappe, Cornelius; Eck, Michael J.; Hershberger, Pamela A.; Scott, David A.; Brandt, Asher L.; Laufer, Stefan A.; Heppner, David E.
A ROLE FOR BRAF FUSION PARTNERS IN ONCOGENIC SIGNALING
NEURO-ONCOLOGY
IF13.4
2024-06-180
OAAI
Misek, Sean; Borgenvik, Anna; Fekade, Ruth; Zhang, Alexander; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung Hyun; Goodale, Amy; Condurat, Alexandra-Larisa; Cordero, Carolina; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadhayay, Pratiti
ELUCIDATING THE ROLE OF FGFR1 ALTERATIONS IN PEDIATRIC GLIOMAS
NEURO-ONCOLOGY
IF13.4
2024-06-180
OAAI
Apfelbaum, April A.; Morin, Eric; Bahadur, Sher; Sturm, Dominik; Novikov, Dana; DiGiacomo, Jeromy; Cameron, Amy; Rechter, Patrick; Cusick, Margaret M.; Oh, Sehee; Jeon, Hyesung; Vogelzang, Jayne; Jones, Jacquelyn; Bossi, Connor; Quang-De Nguyen; Jones, David T. W.; Eck, Michael J.; Fischer, Eric S.; Ligon, Keith L.; Bandopadhayay, Pratiti
BEYOND MAPK SIGNALING - GENOME-SCALE CRISPR/CAS9 SCREENS REVEAL NEW TARGETS FOR TREATMENT OF KIAA1549::BRAF-DRIVEN PEDIATRIC LOW-GRADE GLIOMA
NEURO-ONCOLOGY
IF13.4
2024-06-180
OAAI
Borgenvik, Anna; Misek, Sean; Zhang, Alexander; Fekade, Ruth; Ragnoni, Timothy; Fultineer, Aaron; Zhou, Kevin; Bondeson, Daniel; Novikov, Dana; Bahadur, Sher; Choi, Seung (Riley) H.; Goodale, Amy; Condurat, Alexandra L.; Cordero, Carolina Ortiz; Persky, Nicole; Kiessling, Laura; Root, David; Eck, Michael; Boehm, Jesse; Jones, David; Beroukhim, Rameen; Bandopadahayay, Pratiti (Mimi)
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
COMMUNICATIONS CHEMISTRY
IF6.2
2024-02-207
OAAI
Wittlinger, Florian; Ogboo, Blessing C.; Shevchenko, Ekaterina; Damghani, Tahereh; Pham, Calvin D.; Schaeffner, Ilse K.; Oligny, Brandon T.; Chitnis, Surbhi P.; Beyett, Tyler S.; Rasch, Alexander; Buckley, Brian; Urul, Daniel A.; Shaurova, Tatiana; May, Earl W.; Schaefer, Erik M.; Eck, Michael J.; Hershberger, Pamela A.; Poso, Antti; Laufer, Stefan A.; Heppner, David E.

研究方向

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Pasi A. Jänne
H 指数:163论文数:2,346被引数:12.5万
T
Tyler S. Beyett
H 指数:14论文数:64被引数:775
N
Nathanael S. Gray
H 指数:145论文数:1,469被引数:8.5万
D
David E. Heppner
H 指数:29论文数:253被引数:4,602
E
Eunyoung Park
H 指数:26论文数:74被引数:4,004
M
Matthew Meyerson
H 指数:223论文数:1,861被引数:30.7万
J
Jarrod A. Marto
H 指数:80论文数:327被引数:1.9万
K
Kwok‐Kin Wong
H 指数:140论文数:1,660被引数:7.2万
S
Scott B. Ficarro
H 指数:68论文数:238被引数:1.6万
A
Anna M. Schmoker
H 指数:13论文数:49被引数:679