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D

David E. Heppner

State University of New York
H指数:29
被引数:4,615

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Inside Back Cover: Thinking Outside the Binding Site: A Self-Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

内封底：跳出结合位点思考：一种自包封激酶抑制剂重塑其口袋以实现选择性

Angewandte Chemie-International Edition
IF16.9
2026-10-230
OA
Nico J. Seidler; Monica R. MacDonald; Athina A. Moschopoulou; Sahba Cunningham; Tess M. Weber; Nader N. Nasief; Lorenz Mayer; Frederik W. Hacker; Ekaterina Hermann; Mareike B. Möllers; Yuliia Skliarenko; Tahereh Damghani; Abid N. Manzar; Kaly S. Lin; Ramona Rudalska; Marcia I. Goettert; Lars Zender; Daniel Dauch; Michael Forster; Stefan A. Laufer; David E. Heppner
Thinking Outside the Binding Site: A Self-Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

跳出结合位点：一种自包封激酶抑制剂通过重塑其口袋实现选择性

Angewandte Chemie-International Edition
IF16.9
2026-09-160
OAAI
Nico J. Seidler; Monica R. MacDonald; Athina A. Moschopoulou; Sahba Cunningham; Tess M. Weber; Nader N. Nasief; Lorenz Mayer; Frederik W. Hacker; Ekaterina Hermann; Mareike B. Möllers; Yuliia Skliarenko; Tahereh Damghani; Abid N. Manzar; Kaly S. Lin; Ramona Rudalska; Marcia I. Goettert; Lars Zender; Daniel Dauch; Michael Forster; Stefan A. Laufer; David E. Heppner
Deciphering the Structure−Activity Relationships Underpinning the Linkerology of Bivalent EGFR Inhibitors

解析支撑双价EGFR抑制剂连接体学的构效关系

Journal of Medicinal Chemistry
IF6.8
2026-01-010
PRE
Kishan B. Patel; Ishola Abeeb Akinwumi; Tess M. Weber; Monica R. MacDonald; Stephen J. Collins; Surbhi P. Chitnis; Colton L. Zack; Blessing C. Ogboo; Nader N. Nasief; Emily A. Ouellette; Omobolanle A. Abidakun; Michael J. Eck; Asher L. Brandt; Florian Wittlinger; Stefan Laufer; Hung Tan Nguyen; David E. Heppner
Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent Type V Kinase Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-12-030
PRE
Wittlinger, Florian; Chitnis, Surbhi P.; Pham, Calvin D.; Damghani, Tahereh; Patel, Kishan B.; Moellers, Mareike; Schaeffner, Ilse K.; Abidakun, Omobolanle A.; Deng, Matthew Q.; Ogboo, Blessing C.; Rasch, Alexander; Beyett, Tyler S.; Buckley, Brian; Feru, Frederic; Shaurova, Tatiana; Knappe, Cornelius; Eck, Michael J.; Hershberger, Pamela A.; Scott, David A.; Brandt, Asher L.; Laufer, Stefan A.; Heppner, David E.

研究方向

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A
Albert van der Vliet
H 指数:71论文数:302被引数:1.8万
M
Michael J. Eck
H 指数:89论文数:412被引数:4.7万
M
Milena Hristova
H 指数:24论文数:86被引数:3,699
T
Tyler S. Beyett
H 指数:14论文数:64被引数:780
S
Stefan Laufer
H 指数:70论文数:823被引数:2.0万
B
Blessing C. Ogboo
H 指数:6论文数:26被引数:223
P
Pasi A. Jänne
H 指数:163论文数:2,347被引数:12.6万
C
Christopher M. Dustin
H 指数:13论文数:48被引数:647
A
Aida Habibovic
H 指数:16论文数:84被引数:1,033
K
Karamatullah Danyal
H 指数:21论文数:66被引数:1,328